Epidemiologic analysis of proximal deep vein thrombosis in thai patients: Malignancy, the predominant etiologic factor

Mutirangura, Pramook; Rüengsethakit, Chanian; Wongwanit, Chumpol

doi:10.1007/s00547-004-1027-5

Cited by 11 publications

(9 citation statements)

References 18 publications

(13 reference statements)

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“…The most common cancer associated VTE in Thailand were gynecologic cancers, followed by gastrointestinal and hepatobiliary cancers, lung cancer, and lymphoma [ 11 , 12 ]. Postoperative DVT occurred more frequently in cancer patients than in non-cancer patients (21.1 vs 11.9 %).…”

Section: Reviewmentioning

confidence: 99%

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Cancer-associated thrombosis in Asia

Angchaisuksiri

2016

Thrombosis J

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Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associated with the development of venous thromboembolism (VTE) in Asians appear to be similar to those for Caucasians. Malignancy is the most important acquired risk factor for VTE in Asians. Recent studies have shown that the incidence of VTE is significant in Asian patients with cancer, particularly those in an advanced stage. Cancer associated VTE is more severe and associated with higher morbidity and mortality. Unprovoked VTE is associated with an increased risk of subsequent cancer diagnosis. A number of international and national guidelines are available to provide guidance to healthcare providers to treat and prevent this serious complication based on best-available evidence. Identifying cancer patients at risk for VTE and use of appropriate thromboprophylaxis in these patients can potentially improve morbidity and mortality. Although direct oral anticoagulants (DOACs) may become an attractive treatment for cancer-associated VTE, further clinical trials are needed to evaluate the safety and efficacy of DOACs directly against LMWH in cancer patients.

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Section: Reviewmentioning

confidence: 99%

“…Postoperative DVT occurred more frequently in cancer patients than in non-cancer patients (21.1 vs 11.9 %). Cancer associated VTE was found to be more severe and associated with higher morbidity and mortality [ 12 ].…”

Section: Reviewmentioning

confidence: 99%

Cancer-associated thrombosis in Asia

Angchaisuksiri

2016

Thrombosis J

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“…The main acquired risk factors that are associated with the development of VTE in Asians appear to be similar to those in Western populations. Malignancy is the most important acquired risk factors for VTE in Asians accounting for 16-40% of VTE cases (37,(56)(57)(58). Other risk factors that have been identified include antiphospholipid syndrome, the use of oral contraceptives, prolonged duration of surgery, prolonged immobility, obesity, and increased age.…”

Section: Risk Factors Of Vte In Asiamentioning

confidence: 99%

Venous thromboembolism in Asia – an unrecognised and under-treated problem?

Angchaisuksiri

2011

Thromb Haemost

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Venous thromboembolism (VTE) has been perceived for a long time to be less common in Asian populations, particularly in the Far East, than in Western populations. Generally, thromboprophylaxis is not implemented as frequently as it should be in high-risk patients. However, recent prospective studies undertaken in Asian countries have demonstrated higher rates of VTE after major surgery and in medical wards, approaching those observed in Western populations. Risk factors for VTE are not different in Asian patients from those of Western patients with the exception of thrombophilic mutations. Deficiencies of the natural anticoagulants (protein S, protein C, and antithrombin) are the predominant thrombophilias in Asia whereas factor V Leiden and prothrombin G20210A gene mutation are not found or rarely reported. Further large well-designed clinical studies are needed to evaluate the magnitude of the risk of VTE and the appropriate use of thromboprophylaxis in different clinical situations.

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“…Risk factors, such as surgery, trauma, prolonged bed rest, immobility, and pregnancy, are transient and reversible, while risk factors, such as malignancy and paralysis due to nerve damages, are irreversible. The most common acquired risk factor for VTE in Asians is malignancy; 16% to 40% of VTE cases are cancer-associated [ 40 – 42 ]. Other common acquired risk factors for VTE in Asians include surgery, immobility, obesity, advanced age, and the use of oral contraceptives [ 39 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

The diagnosis and treatment of venous thromboembolism in Asian patients

et al. 2018

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Although the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain the lower prevalence of VTE in Asian populations relative to Western populations include the limited availability of epidemiological data in Asia, ethnic differences in the genetic predisposition to VTE, underdiagnoses, low awareness toward thrombotic disease, and possibly less symptomatic VTE in Asian patients. The clinical assessment, diagnostic testing, and therapeutic considerations for VTE are, in general, the same in Asian populations as they are in Western populations. The management of VTE is based upon balancing the treatment benefits against the risk of bleeding. This is an especially important consideration for Asian populations because of increased risk of intracranial hemorrhage with vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants have shown advantages over current treatment modalities with respect to bleeding outcomes in major phase 3 clinical trials, including in Asian populations. Although anticoagulant therapy has been shown to reduce the risk of postoperative VTE in Western populations, VTE prophylaxis is not administered routinely in Asian countries. Despite advances in the management of VTE, data in Asian populations on the incidence, prevalence, recurrence, risk factors, and management of bleeding complications are limited and there is need for increased awareness. To that end, this review summarizes the available data on the epidemiology, risk stratification, diagnosis, and treatment considerations in the management of VTE in Asia.

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Epidemiologic analysis of proximal deep vein thrombosis in thai patients: Malignancy, the predominant etiologic factor

Abstract: From January 1995 to December 2000, 1555 patients (585 males, 970 females, with a mean age of 52.3 years) with acute limb swelling underwent diagnostic duplex venous ultrasonagraphy at the Vascular

Cited by 11 publications

References 18 publications

Cancer-associated thrombosis in Asia

Cancer-associated thrombosis in Asia

Venous thromboembolism in Asia – an unrecognised and under-treated problem?

The diagnosis and treatment of venous thromboembolism in Asian patients

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