Epidemiologia dos acidentes por Thalassophryne nattereri (niquim) no Estado do Ceará (1992-2002)

Symptoms evoked by Thalassophryne nattereri fish envenomation include local oedema, severe pain and intense necrosis with strikingly inefficient healing, continuing for several weeks or months. Investigations carried out in our laboratory showed that, in the venom-induced acute inflammation, thrombosis in venules and constrictions in arterioles were highly visible, in contrast to a notable lack of inflammatory cell. Nevertheless, the reason that the venom toxins favour delayed local inflammatory response is poorly defined. In this study, we analysed the movement of leucocytes after T. nattereri venom injection in the intraplantar region of Swiss mice, the production of pro-inflammatory mediators and the venom potential to elicit matrix metalloproteinase production and extracellular matrix degradation. Total absence of mononuclear and neutrophil influx was observed until 14 days, but the venom stimulates pro-inflammatory mediator secretion. Matrix metalloproteinases (MMP)-2 and MMP-9 were detected in greater quantities, accompanied by tissue degradation of collagenous fibre. An influx of mononuclear cells was noted very late and at this time the levels of IL-6, IL-1beta and MMP-2 remained high. Additionally, the action of venom on the cytoskeletal organization was assessed in vitro. Swift F-actin disruption and subsequent loss of focal adhesion was noted. Collectively these findings show that the altered specific interaction cell-matrix during the inflammatory process creates an inadequate environment for infiltration of inflammatory cells.

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“…2003). On Ceara State seaside, 16 cases of envenomation by T. nattereri were notified, from 1992 to 2002 (Faco et al. 2005).…”

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confidence: 99%

Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular matrix degradation

Pareja-Santos

Saraiva

Costa

et al. 2009

Int J Experimental Path

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“…A maioria das famílias e gêneros de peixes peçonhentos e venenosos possuem representantes em rios e mares brasileiros (HADDAD JR et al, 2000), e os que mais causam acidentes são as arraias (HADDAD JR. , os bagres (HADDAD JR., 2000), peixeescorpião (FIGUEIREDO e MENEZES, 1978;HADDAD JR. et al, 2003), e o niquim (AUTO, 1992;ALMEIDA e ROCHA, 1989;FONSECA e LOPES, 2000;HADDAD JR et al, 2003;FACÓ et al, 2005).…”

Section: Abordagemunclassified

Oxalato De Cálcio

Lemos¹,

Rocha²,

Morais³

et al. 2023

Toxicologia Clínica: Animais Peçonhentos E Plantas Tóxicas Dos Biomas Do Nordeste

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Toxicologia clínica: animais peçonhentos e plantas tóxicas dos biomas do Nordeste está licenciado sob CC BY 4.0.Esta licença exige que as reutilizações deem crédito aos criadores. Ele permite que os reutilizadores distribuam, remixem, adaptem e construam o material em qualquer meio ou formato, mesmo para fins comerciais. O conteúdo da obra e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, não representando a posição oficial da Editora Amplla. É permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores. Todos os direitos para esta edição foram cedidos à Editora Amplla.

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“…Thalassophryne nattereri toadfish (niquim) is responsible for many accidents in the north and northeast regions of Brazil [4,5]. Accidents with the fish involving fishermen and bathers are more frequent due to the habit of the fish remaining hidden under the sand, between stones or seaweed, and covered by mud in relatively dark places.…”

Section: Introductionmentioning

confidence: 99%

Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom

Lima

Andrade‐Barros

Carvalho

et al. 2023

IJMS

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Thalassophryne nattereri toadfish (niquim) envenomation, common in the hands and feet of bathers and fishermen in the north and northeast regions of Brazil, is characterized by local symptoms such as immediate edema and intense pain. These symptoms progress to necrosis that lasts for an extended period of time, with delayed healing. Wound healing is a complex process characterized by the interdependent role of keratinocytes, fibroblasts, and endothelial and innate cells such as neutrophils and macrophages. Macrophages and neutrophils are actively recruited to clear debris during the inflammatory phase of wound repair, promoting the production of pro-inflammatory mediators, and in the late stage, macrophages promote tissue repair. Our hypothesis is that injury caused by T. nattereri venom (VTn) leads to senescent wounds. In this study, we provide valuable information about the mechanism(s) behind the dysregulated inflammation in wound healing induced by VTn. We demonstrate in mouse paws injected with the venom the installation of γH2AX/p16Ink4a-dependent senescence with persistent neutrophilic inflammation in the proliferation and remodeling phases. VTn induced an imbalance of M1/M2 macrophages by maintaining a high number of TNF-α-producing M1 macrophages in the wound but without the ability to eliminate the persistent neutrophils. Chronic neutrophilic inflammation and senescence were mediated by cytokines such as IL-1α and IL-1β in a caspase-1- and caspase-11-dependent manner. In addition, previous blocking with anti-IL-1α and anti-IL-β neutralizing antibodies and caspase-1 (Ac YVAD-CMK) and caspase-11 (Wedelolactone) inhibitors was essential to control the pro-inflammatory activity of M1 macrophages induced by VTn injection, skewing towards an anti-inflammatory state, and was sufficient to block neutrophil recruitment and senescence.

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Epidemiologia dos acidentes por Thalassophryne nattereri (niquim) no Estado do Ceará (1992-2002)

Cited by 19 publications

References 8 publications

Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular matrix degradation

Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular matrix degradation

Oxalato De Cálcio

Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom

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