Epidemiología de las vasculitis primarias en Colombia y su relación con lo informado para Latinoamérica

Ochoa, Carlos Darío; Ramírez, Fabián; Quintana, Gerardo; Toro, Carlos; Cañas, Carlos A.; Osio, Luis Fernando; Cantillo, Jorge de Jesús; Rondón, Federico; Diaz, Mario; Coral, Paola; Chalem, Philip; Vásquez, Gloría; Uribe, Óscar Osío; Ramírez, Luis Alberto; Quintana, Mario; Arana, Beatriz; Domínguez, Aura; Valle, Rafael F.; Candia, Liliana; Méndez, Odilio; Chalem, Monique; Restrepo, José Félix; A, Antonio Iglesias-Gamarra

doi:10.1016/s0121-8123(09)70103-3

Cited by 10 publications

(11 citation statements)

References 34 publications

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“…In Latin America there are no reports of PACNS, and we do not really know the incidence and prevalence of this entity in Colombia. Takayasu arteritis was the most frequently reported form of primary vasculitis overall, from Colombia [13], Brazil, and Mexico [14]. Even though we think there is some experience with PACNS in Latin America, it has not been published.…”

Section: Discussionmentioning

confidence: 99%

Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center

Coronel-Restrepo

Bonilla-Abadía²,

Cortes³

et al. 2013

Case Reports in Neurological Medicine

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The primary angiitis of the central nervous system (PACNS) is an entity with a very low incidence and prevalence. It is not clear why the inflammatory process of this entity is limited to the cerebral vasculature without systemic manifestations. Its clinical manifestations are very heterogeneous and make clinical diagnosis difficult. In most cases, a brain biopsy is required. Only the clinical suspicion and the ability to recognize the possible clinical and imagenological patterns of presentation make an accurate diagnosis possible. The vast majority of the treatment recommendations are given by series of case reports. The following paper described the clinical, imagenological, and histopathological characteristics of three Colombian patients with PACNS. The strategic therapeutic used in shown.

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Section: Discussionmentioning

confidence: 99%

Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center

Coronel-Restrepo

Bonilla-Abadía²,

Cortes³

et al. 2013

Case Reports in Neurological Medicine

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“…In terms of disease activity, the BVAS was calculated for every patient at diagnosis. Eosinophilic granulomatosis with polyangiitis showed a median score of 10 (8-10); GPA, 12 (10)(11)(12)(13)(14)(15)(16)(17)(18); and MPA, 21 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Birmingham Vasculitis Activity Score was recorded at baseline, and a significant difference was seen between GPA and EGPA (p = 0.005).…”

Section: Resultsmentioning

confidence: 98%

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

et al. 2021

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Background/Objective: Antineutrophil cytoplasmic antibody-associated vasculitides (AAVs) are uncommon systemic autoimmune diseases, of which few reports exist in Latin America. Our aim was to examine AAV evaluated in a high-complexity hospital in southwestern Colombia, with emphasis in severe forms. Methods:A medical records review study of 67 patients was performed, and data were collected from electronic registries. Moderate and severe AAVs were defined as the presence of life-threatening complications, unfavorable Birmingham Vasculitis Activity Score outcomes, and hospitalization requirements at the time of diagnosis and by the last follow-up, between 2011 and 2019. Clinical manifestations, treatment, and outcomes were evaluated. The AAV subtypes were compared.Results: A total of 67 cases were included. The majority were female (n = 44, 65.67%), and the median age was 52 (40-64) years. Granulomatosis with polyangiitis (GPA) was the most frequent with 42 patients (62.68%), followed by microscopic polyangiitis (MPA) and eosinophilic GPA, with 15 patients (22.38%) and 10 patients (14.92%), respectively. Forty-four patients (65.67%) presented pulmonary symptoms. The highest Birmingham Vasculitis Activity Score corresponded to MPA, with 21 (12-25) points. Fifteen patients (22.4%) were admitted to the intensive care unit throughout the course of the disease, of whom 10 had GPA. The longest stay and duration of mechanical ventilation were seen in MPA. The principal treatments were corticosteroids and cyclophosphamide, and the main outcome was end-stage renal disease. Conclusions:In this cohort of AAV, most of cases corresponded to GPA, and pulmonary manifestations were the most common. Microscopic polyangiitis was the more severe subtype as it showed worse impairment in clinical characteristics and intensive care unit requirements.

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“…Llama la atención la baja frecuencia de nefropatía IgA identificada en el periodo en que se ha dispuesto de IF, y aunque la frecuencia es variable en las diferentes series, consideramos que la baja frecuencia de indicación de BRP por hematuria aislada haya influido en este hallazgo 24,25 . Del mismo modo, resulta notoria la baja frecuencia identificada de vasculitis en comparación con otros estudios desarrollados en adultos mayores 10,11 , sin embargo, la frecuencia de vasculitis es particularmente alta en pacientes mayores de 80 años, que fueron minoría en este estudio, a lo que se suma que la incidencia de las vasculitis es bastante variable en los reportes de Latinoamérica 26,27 .…”

Section: Discussionunclassified

Biopsia renal percutánea en pacientes mayores de 60 años. Análisis clínico-patológico

Bacallao-Méndez¹,

López-Marín²,

Llerena-Ferrer³

et al. 2020

NEFRO

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Conocer aspectos relevantes relacionados con la realización de la biopsia renal percutánea (BRP), en los sujetos mayores de 60 años del Instituto de Nefrología (INEF) en el periodo 1988-2018. Material y métodos: Estudio descriptivo transversal. Los datos primarios se obtuvieron de la boleta de biopsia. Todas las biopsias renales fueron realizadas en el INEF siguiendo el protocolo institucional. La información fue procesada con el paquete estadístico SPSS 22.0. Se utilizó análisis de distribución de frecuencias, media y desviación estándar en las variables cuantitativas, y el test de independencia. Resultados: De 2,472 biopsias de riñones propios realizadas en el periodo, 283 correspondieron a pacientes de 60 años y más. La edad media de los pacientes fue de 67.6 años (DE 5.85 años). El 55.1% eran hombres. Se presentaron cinco sangrados (1.8%). El síndrome nefrótico (50.5%) y la disfunción renal aguda (27.3%) fueron las indicaciones más frecuentes. Predominaron las enfermedades glomerulares, y de ellas las glomerulopatías primarias, especialmente glomeruloesclerosis segmentaria y focal (GESF) (17.3%) y glomerulopatía membranosa (GM) (14.5%). Conclusiones: Las indicaciones más comunes de BRP en pacientes ancianos son: síndrome nefrótico y disfunción renal aguda. Los diagnósticos más frecuentes, GESF y GM, que suelen presentarse como síndrome nefrótico.

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Epidemiología de las vasculitis primarias en Colombia y su relación con lo informado para Latinoamérica

Cited by 10 publications

References 34 publications

Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center

Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

Biopsia renal percutánea en pacientes mayores de 60 años. Análisis clínico-patológico

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