Epidemiología de las dermatomicosis en 30 años de estudio en el Instituto de Medicina Tropical Daniel A Carrión, Universidad Nacional Mayor de San Marcos, Lima, Perú

Béjar, Vilma; Villanueva, Freddy; Guevara, Jose M.; González, Sofía; Vergaray, Germán; Abanto, E.; Napán, Kandy; Velasque, Luis; Vergaray, Silvana

doi:10.15381/anales.v75i2.8380

Cited by 5 publications

(7 citation statements)

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“…In Peru, there are no updated reports of dermatophyte agents causing infection in humans; a review of 7185 cases between 1976-2005 reported the presence of T. rubrum, T. mentagrophytes, T. tonsurans, M. canis, M. gypseum, E. floccosum and T. verrucosum. 18 Two studies performed on Cavia porcellus breeding farms have reported the presence of T. mentagrophytes and M. canis. 19,20 The limited availability of tools such as mass spectrometry and molecular methods means that the identification of dermatophytes is mainly based on the recognition of macroscopic and microscopic characteristics of the colonies.…”

Section: Discussionmentioning

confidence: 99%

Identification of Trichophyton benhamiae by MALDI-TOF Mass Spectrometry. First report in Peru

Alvarado,

Quiroz-Reyna,

Quiroz-Chunga

et al. 2024

IJMR

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is an emerging zoophilic dermatophyte that mainly infects skin and scalp and has been reported in Asia, America and Europe. It has two phenotypic variants: one with white colonies and the other with yellow colonies. Morphological identification of is not sufficient and can be confused with or . Genomic or proteomic analysis is required to establish a definitive identification. We present three dermatophyte strains obtained from the skin, nails and scalp of human infections in which macroscopic and microscopic examinations were not sufficient to identify the species. The final identification of was performed using MALDI-TOF mass spectrometry. This is the first report of in Peru.

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Section: Discussionmentioning

confidence: 99%

Identification of Trichophyton benhamiae by MALDI-TOF Mass Spectrometry. First report in Peru

Alvarado,

Quiroz-Reyna,

Quiroz-Chunga

et al. 2024

IJMR

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“…Las infecciones por dermatofitos son producidas por hongos que invaden tejidos queratinizados en humanos, siendo la infección cutánea de mayor prevalencia en el Perú (Béjar et al, 2014) y el mundo (Pires et al, 2014;Sahoo & Mahajan, 2016;Hay, 2018). Las especies que afectan a los humanos pertenecen a los géneros Microsporum y Trichophyton (Pires et al, 2014;Sahoo & Mahajan, 2016).…”

Section: Introductionunclassified

Actividad anti-Trichophyton rubrum del aceite esencial de Clinopodium brevicalyx y elaboración de una emulsión tópica

Ccana

Cruz

Jiménez

2020

Rev. investig. altoandin.

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Clinopodium brevicalyx grows in the southern high Andean regions of Peru and has wide popular use, however to date there is no research on its activity against Trichophyton rubrum, an anthropophilic dermatophyte fungus with an affinity for human keratin and difficult to treat, causing the most common superficial mycoses such as athlete's foot, ringworm and nail infections. The aim of this research was to determine the activity of the essential oil of Clinopodium brevicalyx against Trichophyton rubrum ATCC 28188. The essential oil was obtained by hydrodistillation, the extraction rate was 1.98 ± 0.02% (w/v), and the physicochemical characteristics were: relative density of 0.93654 g/mL, a refractive index of 1.4625, an optical rotation of 2.14°, and pH of 6.20. The chemical composition of the essential oil was determined using a gas chromatograph coupled to a mass spectrometer, identifying as main components: isomentone (44.24 %), menthone (22.22 %) and pulegone (8.23 %). The sensitivity of T. rubrum was evaluated by the disk diffusion method, establishing that at higher oil concentration more sensitivity of the fungus, the minimum inhibitory concentration of the oil was determined by the broth macro-dilution, obtaining a minimum inhibitory concentration (MIC) of 125 μL/mL. The topical emulsion with different percentages of essential oil, showed antifungal activity since 12.5% using the macrodilution method. Concluding that both the essential oil and the emulsion at 12.5% have antifungal activity against Trichophyton rubrum.

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“…Las dermatofitosis son infecciones producidas por hongos llamados dermatofitos, que invaden tejidos queratinizados en humanos y animales, siendo la infección cutánea de mayor prevalencia en el Perú y el mundo [1][2][3][4] . Las especies que afectan a los humanos pertenecen a los géneros Epidermophyton, Microsporum y Trichophyton [1,2] .…”

Section: Introductionunclassified

“…Las especies que afectan a los humanos pertenecen a los géneros Epidermophyton, Microsporum y Trichophyton [1,2] . En nuestra población, la especie Trichophyton mentagrophytes (TM) es el segundo agente dermatofito más encontrado y el cuarto agente infeccioso en dermatomicosis [4] ; sin embargo, en algunos estudios lo encontraron como el más importante [5][6][7] . Los dermatofitos responden bien a los fármacos antifúngicos; pero las pautas de tratamiento suelen ser prolongadas, incrementando así el gasto sanitario en todo el mundo, además de producir efectos colaterales y/o generar resistencia [8,9] .…”

Section: Introductionunclassified

Efecto del extracto etanólico de Tropaeolum majus “mastuerzo” sobre la micosis inducida por Trichophyton mentagrophytes en Rattus norvegicus

et al. 2017

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MS. Efecto del extracto etanólico de Tropaeolum majus "mastuerzo" sobre la micosis inducida por Trichophyton mentagrophytes en Rattus norvegicus. Acta Med Peru. 2017;34(3):196-202 RESUMEN Objetivo: Determinar el efecto del extracto etanólico de Tropaeolum majus "mastuerzo" sobre la micosis inducida por Trichophyton mentagrophytes (TM) en Rattus norvegicus (RN). Materiales y métodos: Experimental aleatorizado, incluyó 21 especímenes RN machos, a los cuales se les indujo una infección micótica mediante modelo de infección superficial en piel; posteriormente al desarrollo de esta, se dividieron aleatoriamente en tres grupos de 7 especímenes cada uno; siendo tratados con placebo (Grupo I), ungüento preparado con el extracto etanólico de Tropaeolum majus "mastuerzo" al 0,4% (grupo II) y Terbinafina al 1% (grupo III), durante 30 días consecutivos, respectivamente. Se realizó un examen clínico de signos y síntomas presentes en las micosis de piel, evaluados a través de una escala arbitraria cualitativa ordinal adaptada para este estudio, asimismo, de estudio micológico con KOH al 20% y por cultivo en Agar Dextrosa Sabouraud para confirmar la dermatofitosis antes y después del tratamiento. Resultados: El Grupo II presentó disminución significativa de los signos clínicos comparado con el Grupo I (p ≤0,001), mientras que al compararlo con el Grupo III se obtuvo una evolución clínica positiva para ambos grupos (p ≥0,05). Conclusión: El extracto etanólico de Tropaeolum majus "mastuerzo" posee un efecto antimicótico sobre la micosis inducida por TM en RN (p <0,05), pudiendo ser una alternativa segura para tratamiento tópico de tiña. Efecto del extracto etanólico de Tropaeolum majus "mastuerzo" sobre la micosis inducida por Trichophyton mentagrophytes en Rattus norvegicus Effect of the ethanol extract of Tropaeolum majus (cress) upon Trichophyton mentagrophites-induced mycosis in Rattus norvegicusEfecto del extracto etanólico de Tropaeolum majus Aguilar-Villanueva DA, et al. ABSTRACT Objective:To determine the effect of the ethanol extract of Tropaeolum majus (cress) upon Trichophyton mentagrophites (TM) -induced tinea in Rattus norvegicus (RN). Materials and methods: This is an experimental randomized trial which included 21 male RN specimens, who were induced a superficial fungal infection; after the infection had developed, the animals were randomly divided in three 7-individual groups; Group I received placebo, Group II received an ointment prepared with a 0.4% ethanol extract of Tropaeolum majus (cress), and Group III received 1% terbinafine during 30 consecutive days, respectively. A clinical exam looking for signs and symptoms present in skin fungal infections was performed, using an arbitrary qualitative ordinal scale that was adapted for this trial. Also, laboratory exams were performed: direct examination of skin samples with 20% KOH, and dextrose-Sabouraud agar cultures in order to confirm the presence of superficial fungal infections before and after therapy. Results: Group II showed a significant reduction of ...

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Epidemiología de las dermatomicosis en 30 años de estudio en el Instituto de Medicina Tropical Daniel A Carrión, Universidad Nacional Mayor de San Marcos, Lima, Perú

Cited by 5 publications

References 1 publication

Identification of Trichophyton benhamiae by MALDI-TOF Mass Spectrometry. First report in Peru

Identification of Trichophyton benhamiae by MALDI-TOF Mass Spectrometry. First report in Peru

Actividad anti-Trichophyton rubrum del aceite esencial de Clinopodium brevicalyx y elaboración de una emulsión tópica

Efecto del extracto etanólico de Tropaeolum majus “mastuerzo” sobre la micosis inducida por Trichophyton mentagrophytes en Rattus norvegicus

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