Epidemiologia da infecção pela dengue em Ribeirão Preto, SP, Brasil

Rodrigues, Evandro Luís Linhari; Dal-Fabbro, Amaury Lélis; Salomão, Rogério; Ferreira, Ivani B.; Rocco, Iray Maria; Fonseca, Benedito Antônio Lopes da

doi:10.1590/s0034-89102002000200007

Cited by 23 publications

(17 citation statements)

References 6 publications

(4 reference statements)

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“…Regarding the gender of the patients, Rodrigues, Scander and Casali showed in their studies that there were no statistically significant differences, as also seen in Ceará in 2003 [7][8][9] . On the other hand, Montenegro, investigating 14 patients who progressed to death in Recife, suggested that male gender predominated 3 .…”

Section: Resultsmentioning

confidence: 99%

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Clinical and epidemiological characterization of dengue hemorrhagic fever cases in northeastern, Brazil

Cavalcanti

Coêlho

Vilar

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The dengue hemorrhagic dengue (DHF) remains an important public health problem in Brazil. The objective of this study was to analyze the epidemiological characteristics of DHF cases during the 2003 epidemic in Ceará. Methods: Suspected DHF cases with onset of symptoms between January and December 2003 were investigated. Results: 37,964 classic dengue cases and 291 DHF cases were reported. Among the cases discarded, 75.5% were serologically positive but did not meet the criteria recommended by the World Health Organization (WHO). The DHF patients' median age was 30 years (2 -88). Among the hemorrhagic manifestations, petechiae were the most (32.6%) frequent. Cases of gastrointestinal bleeding, ascites, pericardial pleural effusion, hepatomegaly, hypotension and shock showed higher risk of progression to death (p <0.05). Conclusions: The introduction of a new serotype (DEnV-3) in Ceará, which encountered a susceptible population and high vector density, may have been the primary agent responsible for the magnitude of the epidemic. Timely and appropriate medical care, along with an organized care structure are essential for reducing its lethality.

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Section: Resultsmentioning

confidence: 99%

“…Regarding the age of the patients with DHF, Montenegro 8 demonstrated that more than 50% were between 20 and 59 years old. Studies in Cuba and Puerto Rico have shown predominance among adults 6,10 .…”

Section: Resultsmentioning

confidence: 99%

Clinical and epidemiological characterization of dengue hemorrhagic fever cases in northeastern, Brazil

Cavalcanti

Coêlho

Vilar

et al. 2010

Rev. Soc. Bras. Med. Trop.

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“…During the 1997 Cuban DENV-2 epidemic, all 2° infections were clinically overt, but only 3–6% of 1° infections were apparent (55). In the Brazilian studies, inapparent rates were 27 and 53% in 1° infections vs. 37 and 39% in 2° infections (22, 23). In Colombia, repeated cross-sectional studies were carried out over a period of 17 months; 259 of 3,189 individuals showed clinical signs of viral infection and/or anti-DENV IgM antibodies; 86% were inapparent (24).…”

Section: Retrospective and Outbreak Studiesmentioning

confidence: 91%

Epidemiological Risk Factors Associated with High Global Frequency of Inapparent Dengue Virus Infections

et al. 2014

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Dengue is a major international public health concern, and the number of outbreaks has escalated greatly. Human migration and international trade and travel are constantly introducing new vectors and pathogens into novel geographic areas. Of particular interest is the extent to which dengue virus (DENV) infections are subclinical or inapparent. Not only may such infections contribute to the global spread of DENV by human migration, but also seroprevalence rates in naïve populations may be initially high despite minimal numbers of detectable clinical cases. As the probability of severe disease is increased in secondary infections, populations may thus be primed, with serious public health consequences following introduction of a new serotype. In addition, pre-existing immunity from inapparent infections may affect vaccine uptake, and the ratio of clinically apparent to inapparent infection could affect the interpretation of vaccine trials. We performed a literature search for inapparent DENV infections and provide an analytical review of their frequency and associated risk factors. Inapparent rates were highly variable, but “inapparent” was the major outcome of infection in all prospective studies. Differences in the epidemiological context and type of surveillance account for much of the variability in inapparent infection rates. However, one particular epidemiological pattern was shared by four longitudinal cohort studies: the rate of inapparent DENV infections was positively correlated with the incidence of disease the previous year, strongly supporting an important role for short-term heterotypic immunity in determining the outcome of infection. Primary and secondary infections were equally likely to be inapparent. Knowledge of the extent to which viruses from inapparent infections are transmissible to mosquitoes is urgently needed. Inapparent infections need to be considered for their impact on disease severity, transmission dynamics, and vaccine efficacy and uptake.

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“…Ying et al (2007) found the following clinical findings in DF: fever in all patients, headache, myalgia, bone soreness and skin rash more than 50%. Rodrigues et al (2002) found in DF:…”

Section: Discussionmentioning

confidence: 96%