Epidemics of Aseptic Meningitis in Kyoungsangnamdo from March to October, 1997

Park, Sun Young; Kwun, Oh Soo; Kim, Won Yeob; Jung, Won Jo; Hyuk, Sang; Kim, Sang Ki; Nam, Sungjin; Jo, Seong-Rae; Gu, Bon Cheon; Lee, Kyu-Man

doi:10.14776/kjpid.1998.5.1.104

Cited by 5 publications

(2 citation statements)

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“…Similar to recent studies [ 21 ], males account for 64.3% of all patients in this study and are prone to severe symptoms. Although some studies reported that aged 4-9 years [ 22 ] or 5-10 years [ 23 ] may be the most susceptive period, we found, as in many studies [ 13 ] that patients under 5 years of age are at the highest risk, with most severe symptoms in the youngest patients. Rural preference is also observed, especially in patients with the most severe symptoms.…”

Section: Discussionsupporting

confidence: 54%

Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

Liu

et al. 2012

Virol J

115

101

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BackgroundTo explore the relationship between enteroviruses and hospitalized children with hand, foot and mouth disease (HFMD) complicated with nervous system disease. 234 hospitalized HFMD patients treated in Shengjing Hospital, Liaoning Province were analyzed retrospectively. Based on the presence and severity of nervous system disease, the patients were grouped as follows: general patients, severely ill patients, critically ill patients and fatal patients. Based on the detected pathogen, the patients were grouped as follows: Enterovirus 71 (EV71) infection, coxsackie A16 (CA16) infection and other enterovirus (OE) infection.ResultsOf the 423 hospitalized patients, most were admitted in July 2010(129/423, 30.5%). Enteroviruses were detected in 177(41.8%). 272/423 patients were male (64.3%), and fatal patients had the greatest proportion of male patients (p < 0.05). EV71 infection was found in 89/423 patients (21%). CA16 infection was detected in 8/423 patients (16.1%). Compared to group CA16, patients in group EV71 were hospitalized earlier, and the duration of hospitalization was longer (p < 0.05). Of the 92 patients with nervous system damage, 65 were infected with EV71 and 19 were infected with CA16. Among these CA16 infected patients, 2 had brainstem encephalitis and 1 had AFP. There were more patients with nervous system dysfunction in group EV71 than in groups CA16 or OE (p < 0.05). The 5 fatalities all occurred in group EV71 patients (p < 0.05). Infection with EV71 was most likely to cause neurogenic pulmonary edema (p < 0.05). Patients in group EV71 had a higher rate of suffering from coma and limb movement disorder than patients in groups CA16 or OE (p < 0.05).ConclusionThe disease progresses faster in EV71-infected HFMD patients. These patients are more likely to suffer nervous system damage, neurogenic pulmonary edema, severe sequelae or death. CA16 and other enteroviruses can also cause HFMD with severe nervous system complications.

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Section: Discussionsupporting

confidence: 54%

Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

Liu

et al. 2012

Virol J

115

101

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“…Consistent with this observation, the gender ratio was 1.2:1 in this study, suggesting a slightly higher prevalence in males ( Table 1 ). It has been reported that most patients were 5 years old or younger 12) , but there are also reports that the highest incidence rate was observed in the 4-9 years age group 13) or 5-10 years of age 16) . This study showed a broad spectrum of age distribution, ranging from 6 months to 12 years of age, but 60% of patients were 5 years old or younger (1-2 years and 3-4 years age group: 24%, 4-5 years: 12%) with a mean age of 3.55±2.41, showing that most cases are observed in children 5 years old or younger ( Table 1 ).…”

Section: Discussionmentioning

confidence: 97%

Clinical manifestations of CNS infections caused by enterovirus type 71

Choi

et al. 2011

Korean J Pediatr

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PurposeEnterovirus 71, one of the enteroviruses that are responsible for both hand-foot-and-mouth disease and herpangina, can cause neural injury. During periods of endemic spread of hand-foot-andmouth disease caused by enterovirus 71, CNS infections are also frequently diagnosed and may lead to increased complications from neural injury, as well as death. We present the results of our epidemiologic research on the clinical manifestations of children with CNS infections caused by enterovirus 71.MethodsThe study group consisted of 42 patients admitted for CNS infection by enterovirus 71 between April 2009 and October 2009 at the Department of Pediatrics of 5 major hospitals affiliated with the Catholic University of Korea. We retrospectively reviewed initial symptoms and laboratory findings on admission, the specimen from which enterovirus 71 was isolated, fever duration, admission period, treatment and progress, and complications. We compared aseptic meningitis patients with encephalitis patients.ResultsOf the 42 patients (23 men, 19 women), hand-foot-and-mouth disease was most prevalent (n=39), followed by herpangina (n=3), upon initial clinical diagnosis. Among the 42 patients, 15 (35.7%) were classified as severe, while 27 (64.3%) were classified as mild. Factors such as age, fever duration, presence of seizure, and use of intravenous immunoglobulin (IVIG) were statistically different between the 2 groups.ConclusionOur results indicate that patients with severe infection caused by enterovirus 71 tended to be less than 3 years old, presented with at least 3 days of fever as well as seizure activity, and received IVIG treatment.

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