Epidemical features of HAdV-3 and HAdV-7 in pediatric pneumonia in Chongqing, China

Abstract

Human adenoviruses (HAdV) of species B, C, and E (HAdV-B, -C, -E) are frequent causative agents of acute respiratory infections worldwide. No specific analysis has been done on the epidemiological and clinical features of HAdV in pediatric pneumonia in China. Nasopharyngeal aspirates were collected from hospitalized children with pneumonia from June 2009 to May 2014. All samples that tested positive for HAdV were typed by sequencing the hexon and fiber genes. From a total of 3089 samples, 208 (6.7 %) were positive for HAdV, identified as belonging to HAdV-B (186, 89.4 %), HAdV-C (9, 4.3 %) and HAdV-E (1, 0.5 %). HAdV-7 (104, 50.0 %) and HAdV-3 (78, 37.5 %) were the two major types, followed by HAdV-1, HAdV-55 and HAdV-14. There were 87 (41.8 %) single HAdV infections, of which 80 % were HAdV-7 infections. Multivariate analysis showed that single infections with HAdV-7 were associated with a higher prevalence of severe pneumonia. Temporal patterns showed that, except for a simultaneous outbreak of HAdV-3 and HAdV-7 during the years 2010-2011, HAdV-7 and HAdV-3 were alternately predominant, and the dominance shifted to HAdV-3 after 2014. Identification of the predominant HAdV genotypes and their epidemical features is useful for determining preventive strategies. HAdV-7 associated severe pneumonia needs to be considered with high priority in clinical practice.

Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan, China

“…To date, 79 HAdV types have been identified and are classified into seven species (A‐G) . HAdV types 1 to 7 account for approximately 80% of all HAdV‐infected cases in children . HAdV‐3 and HAdV‐7 are closely associated with LRTIs .…”

“…HAdV types 1 to 7 account for approximately 80% of all HAdV‐infected cases in children . HAdV‐3 and HAdV‐7 are closely associated with LRTIs . HAdV‐7 may lead to severe respiratory tract infections and HAdV‐7 infection is associated with a high incidence of death and severe sequelae …”

“…The dominant type and detection rate of HAdV vary in different countries and eras. Epidemic outbreaks of HAdV‐3 and HAdV‐7 infections occurred in children during the 1950s and 1960s in China . HAdV‐3 and HAdV‐7 infections are currently the most severe infections in Northern China with mortality rates of 16.6% to 33.3%.…”

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

“…Of the seven HAdV species, species B (mostly HAdV-3, -7, -14, and -55) and species E (HAdV-4) are highly associated with ARD, which account for a high proportion of respiratory diseases both in children and adults throughout the world1211121314151617181920212223. HAdV-7 is one of the most important respiratory HAdVs and has been circulating both in military and civilian populations.…”

Outbreak of acute febrile respiratory illness caused by human adenovirus B P14H11F14 in a military training camp in Shandong China

“…Human adenoviruses (HAdVs) are responsible for a broad spectrum of clinical diseases, including febrile respiratory illnesses (FRI), gastroenteritis, pneumonia, and kidney infections [1][2][3][4]. These ubiquitous viruses belong to the genus Mastadenovirus in the family Adenoviridae.…”