Epidemic Sindbis Virus Infection in Finland: A Population-Based Case-Control Study of Risk Factors

Sane, Jussi; Guedes, Sandra; Ollgren, Jukka; Kurkela, Satu; Klemets, Peter; Vapalahti, Olli; Kela, Eija; Lyytikäinen, Outi; Nuorti, J. Pekka

doi:10.1093/infdis/jir267

Cited by 18 publications

(30 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The seroprevalence increased with age reaching 15.4% in the 60–69 years age group . In 2009, the incidence peaked in the 50–59 years age group (4.6/100 000/year) . In Sweden, of all confirmed clinical SINV infections in 1981–1989 ( N = 245) more than two thirds were diagnosed in those aged 30–59 years, while the proportion of adolescents (<20 years) was 6% .…”

Section: Epidemiologymentioning

confidence: 99%

Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis

et al. 2016

Self Cite

View full text Add to dashboard Cite

Sindbis virus (SINV; family Togaviridae, genus Alphavirus) is an enveloped RNA virus widely distributed in Eurasia, Africa, Oceania and Australia. SINV is transmitted among its natural bird hosts via mosquitoes. Human disease caused by SINV infection has been reported mainly in South Africa and in Northern Europe. Vector mosquito abundance affects the annual incidence of SINV infections with occasional outbreaks of up to 1500 patients. Symptoms include fever, malaise, rash and musculoskeletal pain. In a significant portion of patients the debilitating musculoskeletal symptoms persist for years. Chronic disease after SINV infection shares many features with autoimmune diseases. Currently there is no specific treatment available. Recently SINV infections have been detected outside the previously known distribution range. In this article we will summarize the current knowledge on epidemiology, clinical disease and pathogenesis of SINV infection in man. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Serological surveys in Finland [264] and Sweden [261] indicate that as much as 95% of all SINV infections may not be diagnosed. After an incubation period of four days (2-10 days range) approximately [265], patients develop some signs and symptoms that are similar to other arthritogenic alphaviruses. The main symptoms experienced by patients with the disease are rash, arthralgia, and fever [266].…”

Section: Potential Future Outbreaksmentioning

confidence: 99%

Epidemic Alphaviruses: Ecology, Emergence and Outbreaks

et al. 2020

View full text Add to dashboard Cite

Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the genus Alphavirus pose a significant risk to both animal and human health. Human alphaviral disease presents with either arthritogenic or encephalitic manifestations and is associated with significant morbidity and/or mortality. Unfortunately, there are presently no vaccines or antiviral measures approved for human use. The present review examines the ecology, epidemiology, disease, past outbreaks, and potential to cause contemporary outbreaks for several alphavirus pathogens.

show abstract

“…In addition, RRV-infected patients with pre-dating joint disease such as OA, gout, or psoriatic arthritis complained of worse arthralgia months after disease onset [15,20]. Similarly, the SINV-related alphavirus that causes Pogosta disease has been reported to cause exacerbation of joint arthralgia in OA patients [19,80]. These observations suggest that underlying arthritic conditions may be associated with disease exacerbation after alphavirus infection.…”

Section: Underlying Inflammatory Arthritis: Potential Risk Factor Formentioning

confidence: 99%

Arthritogenic alphaviruses: new insights into arthritis and bone pathology

Chen

Foo

Sims

et al. 2015

Trends in Microbiology

View full text Add to dashboard Cite

Epidemic Sindbis Virus Infection in Finland: A Population-Based Case-Control Study of Risk Factors

Abstract: Educating the public in endemic areas to avoid mosquito exposure and use protective measures remain important prevention measures for SINV infection.

Cited by 18 publications

References 38 publications

Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis

Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis

Epidemic Alphaviruses: Ecology, Emergence and Outbreaks

Arthritogenic alphaviruses: new insights into arthritis and bone pathology

Contact Info

Product

Resources

About