Epidemic Optic Neuropathy Is Evident in the Somalian Population

Dalmar, Abdirisak; Hodson, Katherine; Plant, Gordon T.

doi:10.1097/wno.0b013e31820d1604

Cited by 12 publications

(11 citation statements)

References 11 publications

(16 reference statements)

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“…The result was a case definition more stringent than that used in other population studies. [3][4][5]29 Most participants had spent their entire current incarceration at Beon Prison. However, of those who had not, only four and one had spent less than 6 and 3 months, respectively, in this facility at the time of the survey.…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of optic nerve function was less problematic; the chosen VA threshold was comparable with that of other population studies, [3][4][5]8 interpretation of VF loss was according to standard clinical practice, and, specificity for acquired color vision defects was increased by accepting only asymmetric function. 28 Unfortunately, pupil and contrast sensitivity data could not be used due to inconsistent testing conditions.…”

Section: Discussionmentioning

confidence: 99%

“…4 Color vision (CV): abnormal if one eye correctly identified nine or less Ishihara plates and there was a differential of at least two plates for the fellow eye. 5 No optic neuropathy: normal ONH, VA, VF and CV. 6 Possible optic neuropathy: normal ONH and one or two abnormal of VA, VF and CV; or, abnormal ONH alone.…”

Section: Variables and Outcomementioning

confidence: 97%

“…[1][2][3][4][5][6][7] These share some commonalities with a 1991-1993 ON epidemic in Cuba. 8 Such ON is typically characterized by progressive bilateral vision loss (although not necessarily symmetrical), with impaired color perception, visual field scotomata and optic nerve head (ONH) pallor.…”

Section: Introductionmentioning

confidence: 99%

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Optic Neuropathy among a Prison Population in Papua New Guinea

Tousignant

Brian

Venn³

et al. 2013

Ophthalmic Epidemiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Variables and Outcomementioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optic Neuropathy among a Prison Population in Papua New Guinea

Tousignant

Brian

Venn³

et al. 2013

Ophthalmic Epidemiology

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“…[1][2][3][4]15,16,21,22,26,[35][36][37]39 These diseases appear to be due to acquired or inherited mitochondrial failure.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomographic Comparison of Cuban Epidemic and Leber’s Hereditary Optic Neuropathy

Santiesteban-Freixas

Pola-Alvarado

Columbie-Garbey

et al. 2015

Neuro-Ophthalmology

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Following the epidemic of optic and peripheral neuropathy, which occurred in Cuba between 1991 and 1993, a number of patients have been re-evaluated, including testing with optical coherence tomography (OCT) and electrophysiology. At the same time, a number of patients with Leber's hereditary optic neuropathy have also been evaluated. The purpose of this study was to detect residual loss of retinal nerve fibre layer (RNFL) in patients who suffered Cuban epidemic optic neuropathy (CEON), and to compare these findings with those in patients with Leber's hereditary optic neuropathy (LHON). Optical coherence tomography as well as clinical examinations were performed on 11 patients diagnosed with CEON 15 years following the epidemic and 14 patients with LHON. OCT in CEON patients showed thinning of the RNFL in the temporal sector and normal thickness in other quadrants. However, patients with chronic LHON had more diffuse RNFL loss throughout the retina. OCT findings corresponded with clinical findings in CEON and LHON. There was drop out of the papillomacular bundle in both diseases. Two patients in the acute stages of LHON and three LHON carriers showed thinning of the temporal RNFL only. This is the first report of OCT in CEON that shows residual damage in the papillomacular bundle compared with chronic LHON where there is more diffuse and progressive loss of the RNFL. The importance of OCT for the diagnosis and evaluation of similar optic neuropathies is emphasised.

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