Epidemic of difficult-to-treat tinea in India: Current scenario, culprits, and curbing strategies

Shenoy, Manjunath Mala; Jayaraman, Jyothi

doi:10.4103/amhs.amhs_72_19

Cited by 27 publications

(28 citation statements)

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“…Recently, there is a considerable number of dermatophyte species that are problematic in diagnostics; therefore, rapid and reliable identification is of paramount importance Kalita et al 2019;Shenoy and Jayaraman 2019;Vineetha et al 2019). Interestingly, the number of dermatophyte species causing infection in humans increases (de Hoog et al 2017).…”

Section: Development Of a Diagnostic Pathmentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

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Dermatophytes are the aetiological factors of a majority of superficial fungal infections. What distinguishes them from other pathogenic filamentous fungi is their unique ability to degrade keratin. The remarkable ability of this group of fungi to survive in different ecosystems results from their morphological and ecological diversity as well as high adaptability to changing environmental conditions. Paradoxically, despite the progress in medicine, the prevalence of dermatophyte infections is increasing from year to year. At the beginning of the third millennium, practical diagnostic and therapeutic options are still very limited. This review focuses on understanding the major problems in this aspect of dermatophyte infections and indicates future strategies and perspectives for novel approaches to identification and drugs for elimination of dermatophytes. Particular importance is placed on development of a strategy for a diagnostic pathway and implementation of rapid and reliable diagnostics methods designed by international teams. Furthermore, among compounds that currently arouse great interest, representatives of terpenoids, alkaloids, saponins, flavonoids and essential oils deserve attention. Many of these compounds are undergoing clinical trials as potential antifungal agents, and future research should focus on attempts at determination of the applicability of tested substances. Finally, the advantages and disadvantages in implementation of new diagnostic paths and medicinal substances for routine use are indicated. Journal of Applied Microbiology

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Section: Development Of a Diagnostic Pathmentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

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“…The deleterious role of FDCs containing antifungals and potent topical corticosteroids in the ongoing epidemic-like scenario of chronic recalcitrant dermatophytosis in India cannot be denied. [ 3 10 11 12 13 14 ] It has also been hypothesized that the potent steroid along with antifungal antibacterial agents alters the cutaneous microbiome. [ 14 ] This may be one of the factors responsible for the rather sudden epidemiologic shift from Trichophyton rubrum to T. mentagrophytes ITS genotype VIII as the predominant causative species of tinea in India.…”

mentioning

confidence: 99%

Topical itraconazole formulations: Unscrupulous pharmaceutical companies and lax indian drug regulators endangering a precious drug

Verma¹,

Saraswat²,

Rao

et al. 2020

Indian Dermatol Online J

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“…Fungal infections, having a favour for immunocompromised hosts, remains a major area of concern in such immunosuppressed patients. Over the recent several years, incidence of dermatophytosis in India has increased and clinicians have encountered atypical and recalcitrant presentations of dermatophytosis [1]. SLE manifests with many specific and nonspecific cutaneous lesions that may resemble many common and uncommon dermatoses.…”

Section: Introductionmentioning

confidence: 99%

Atypical dermatophytosis in a case of systemic lupus erythematosus

Shenoy¹,

Kilaru²,

Razak³

et al. 2020

Our Dermatol Online

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Systemic lupus erythematosus (SLE) is a multiorgan autoimmune connective tissue disease with many muco-cutaneous manifestations. We report a case of SLE on treatment presented with scaly erythematous plaques on the trunk and extremities and diffuse scaly erythematous macular lesions on the face resembling cutaneous lupus erythematosus. Laboratory evaluation established a diagnosis of tinea corporis with faciei. He responded to long term itraconazole therapy. This case focuses on the modification of tinea in an autoimmune disorder on immunosuppressive therapy and its therapeutic implications.

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Epidemic of difficult-to-treat tinea in India: Current scenario, culprits, and curbing strategies

Cited by 27 publications

References 1 publication

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Topical itraconazole formulations: Unscrupulous pharmaceutical companies and lax indian drug regulators endangering a precious drug

Atypical dermatophytosis in a case of systemic lupus erythematosus

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