Epidemic Neuromyasthenia

Shelokov, Alexis; Habel, Karl; Verder, Elizabeth; Welsh, William J.

doi:10.1056/nejm195708222570801

Cited by 65 publications

(6 citation statements)

References 8 publications

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“…The epidemic at Rockville, U.S.A. (Shelokov et al, 1957), was associated with the isolation, from a number of the ENM patients, of Bethesda-Ballerup paracolon organisms which appear to have triggered off the disease in the same manners as infection with poliomyelitis virus precipitated other epidemics. There was an extensive outbreak of ENM in the North of England in 1955.…”

Section: District Epidemic In New Yorkmentioning

confidence: 99%

Early outbreaks of ‘epidemic neuromyasthenia’

Parish

1978

Postgraduate Medical Journal

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Section: District Epidemic In New Yorkmentioning

confidence: 99%

Early outbreaks of ‘epidemic neuromyasthenia’

Parish

1978

Postgraduate Medical Journal

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“…Reports [17][18][19] describing disease outbreaks that have resembled ME/CFS in "closed populations" such as hospitals and convents can be traced back more than 60 years. Because these outbreaks occurred among persons in close proximity, it has been suggested that the ME/CFS is either infectious or results from an infectious agent.…”

Section: Microbial Triggersmentioning

confidence: 99%

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review

Larrimore¹,

Ramnot²,

Jaghab³

et al. 2019

The Journal of the American Osteopathic Association

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overall lack of awareness within the medical community. As a result, patients are often frustrated by the difficulties in acquiring a diagnosis and from the overall lack of available treatments. In an effort to increase awareness, this review discusses disease pathophysiology, clinical presentation, and treatment options, while also highlighting the benefits of an osteopathic approach.

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“…Reports dating back more than 60 years describing disease outbreaks in “closed populations” such as in hospitals and convents producing symptoms consistent with ME/CFS raised the possibility of an infectious aetiology or, an association of infection with disease onset [ 1 , 19 , 20 ]. ME/CFS patients often present with flu like symptoms with an acute onset presentation being more common in these patients than in those suffering from chronic fatigue only [ 21 ].…”

Section: Infections and Me/cfsmentioning

confidence: 99%

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

Navaneetharaja

Griffiths

Wileman

et al. 2016

JCM

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous disorder of significant societal impact that is proposed to involve both host and environmentally derived aetiologies that may be autoimmune in nature. Immune-related symptoms of at least moderate severity persisting for prolonged periods of time are common in ME/CFS patients and B cell depletion therapy is of significant therapeutic benefit. The origin of these symptoms and whether it is infectious or inflammatory in nature is not clear, with seeking evidence of acute or chronic virus infections contributing to the induction of autoimmune processes in ME/CFS being an area of recent interest. This article provides a comprehensive review of the current evidence supporting an infectious aetiology for ME/CFS leading us to propose the novel concept that the intestinal microbiota and in particular members of the virome are a source of the “infectious” trigger of the disease. Such an approach has the potential to identify disease biomarkers and influence therapeutics, providing much-needed approaches in preventing and managing a disease desperately in need of confronting.

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Epidemic Neuromyasthenia

Cited by 65 publications

References 8 publications

Early outbreaks of ‘epidemic neuromyasthenia’

Early outbreaks of ‘epidemic neuromyasthenia’

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

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