Epidemic Meningitis of the Newborn Caused by Flavobacteria

Cabrera, Hugo Álvarez-Argüelles

doi:10.1001/archpedi.1961.04020040017004

Cited by 87 publications

(14 citation statements)

References 5 publications

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“…Within this group, genetic techniques were previously available only for members of the genus Bacteroides and related bacteria in the genera Prevotella (47) and Porphyromonas (13). Cytophagas and flavobacteria are important as pathogens of animals and humans (3,6,8,9,30,31,45), as agents of biodegradation (18,28,38), and as producers of novel antibiotics and antitumor drugs (11,26,35,38). We have recently demonstrated that some of the genetic tools described above function in a number of bacteria belonging to the Cytophaga-Flavobacterium group (data not shown).…”

Section: Discussionmentioning

confidence: 99%

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Development of techniques for the genetic manipulation of the gliding bacterium Cytophaga johnsonae

1996

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Cytophaga johnsonae displays many features that make it an excellent model of bacterial gliding motility. Unfortunately, genetic analyses of C. johnsonae, or any related gliding bacteria, were not possible because of a complete lack of selectable markers, cloning vectors, transposons, and convenient methods of gene transfer. As a first step toward a molecular analysis of gliding motility of C. johnsonae, we developed these genetic techniques and tools. Common broad-host-range plasmids and transposons did not function in C. johnsonae. We identified one Bacteroides transposon, Tn4351, that could be introduced into C. johnsonae on plasmid R751 by conjugation from Escherichia coli. Tn4351 inserted in the C. johnsonae genome and conferred erythromycin resistance. Tn4351 insertions resulted in auxotrophic mutations and motility mutations. We constructed novel plasmids and cosmids for genetic analyses of C. johnsonae. These cloning vectors are derived from a small cryptic plasmid (pCP1) that we identified in the fish pathogen Cytophaga psychrophila D12. These plasmids contain the ermF (erythromycin resistance) gene from Tn4351 and a variety of features that facilitate propagation and selection in E. coli and conjugative transfer from E. coli to C. johnsonae.

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Section: Discussionmentioning

confidence: 99%

“…This group of bacteria includes a number of animal and human pathogens (3,6,8,9,30,31,45), bacteria capable of degrading complex biomolecules (18,28,38), and bacteria that produce novel and potentially useful antibiotics and other bioactive compounds (11,26,35,38). Adaptation of the tools described here should allow genetic analyses of many of these bacteria.…”

mentioning

confidence: 99%

Development of techniques for the genetic manipulation of the gliding bacterium Cytophaga johnsonae

1996

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“…(Brody, Moore & King, 1958;King, 1959;Cabrera & Davis, 1961;Sugathadasa & Arseculeratne, 1963 ;Nelson & Shelton, 1965. ) Only one species, FZavobacterium meningosepticum, was included and all of the I I strains were identified correctly.…”

Section: Separate Taxamentioning

confidence: 99%

Identification of Bacteria by Computer: Identification of Reference Strains

Bascomb

Lapage

Curtis

et al. 1973

Journal of General Microbiology

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SUMMARYThe results of the identification of 1079 reference strains of Gram-negative, aerobic, rod-shaped bacteria by a probabilistic method in a computer are given.Comparison of identification by conventional methods and by computer showed that 90.8 % of fermentative and 82.1 % of non-fermentative strains could be identified on the best available probability matrix. Many of these strains were atypical and had caused difficulty in identification in the medical diagnostic laboratory. The implications of various factors in successful computer identification are discussed and the results are given for each taxon by genus and species.

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“…Flavobacteria uncommonly cause human disease but have been associated with such serious infections as endocarditis (11,16), meningitis (2,6,7), bacteremia (10,12), and pneumonia (13). Selection of an appropriate chemotherapeutic agent for such infections is often difficult because of the typical resistance ofthese organisms to antimicrobial agents commonly tested against gram-negative bacilli in the clinical microbiology laboratory.…”

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confidence: 99%

Antimicrobial Susceptibility of Flavobacteria

Aber

Wennersten

Moellering

1978

Antimicrob Agents Chemother

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Antimicrobial susceptibility patterns of 28 clinical isolates of Flavobacterium sp. were determined by standard disk diffusion technique and by antimicrobial dilution in agar. Rifampin, clindamycin, trimethoprim-sulfamethoxazole, cefoxitin, and vancomycin are among the antimicrobial agents which may be clinically useful to treat infections caused by flavobacteria. All 28 isolates were resistant to erythromycin with minimal inhibitory concentrations of 32 ,tg/ml or more.Currently recommended interpretive zones of inhibition by disk diffusion did not reliably predict antimicrobial susceptibility of the 28 flavobacteria isolates when compared with the agar dilution technique, and, therefore, a more direct measurement of minimal inhibitory or bactericidal concentration is recommended.

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Epidemic Meningitis of the Newborn Caused by Flavobacteria

Cited by 87 publications

References 5 publications

Development of techniques for the genetic manipulation of the gliding bacterium Cytophaga johnsonae

Development of techniques for the genetic manipulation of the gliding bacterium Cytophaga johnsonae

Identification of Bacteria by Computer: Identification of Reference Strains

Antimicrobial Susceptibility of Flavobacteria

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