Epidemic meningitis, meningococcaemia, and Neisseria meningitidis

Stephens, David S.; Greenwood, Brian; Brandtzæg, Petter

doi:10.1016/s0140-6736(07)61016-2

Cited by 852 publications

(930 citation statements)

References 164 publications

Supporting

Mentioning

813

Contrasting

Unclassified

Order By: Relevance

“…They are therefore regarded as a key virulence factor of invasive strains and represent the target of the currently available vaccines against serogroup A, C, Y and W meningococcal invasive disease [30]. After the introduction of the meningococcal serogroup A polysaccharide vaccine MenAfriVac [31–33], W, C, X and Y clones represent the main etiological agent of epidemics in the meningitis belt [34]. Therefore, it is important to understand the dynamics of the capsule synthesis genes and how mutations in this locus translate into phenotypic, structural and functional effects.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Ispasanie

Micoli²,

Lamelas

et al. 2018

Virulence

View full text Add to dashboard Cite

Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mutation hotspot. Structural and functional properties of the capsule of 11 carriage and two disease isolates with non-synonymous point mutations or stop codons in capsule synthesis genes were analyzed for their capsular polysaccharide expression, recognition by antibodies and sensitivity to bactericidal killing. Eight of eleven carriage isolates presenting capsule locus mutations expressed no or reduced amounts of capsule. One isolate with a stop codon in the O-acetyltransferase gene expressed non-O-acetylated polysaccharide, and was not recognized by anti-capsule antibodies. Capsule and O-acetylation deficient mutants were resistant to complement deposition and killing mediated by anti-capsular antibodies, but not by anti-lipopolysaccharide antibodies. Two capsule polymerase mutants, one carriage and one case isolate, showed capsule over-expression and increased resistance against bactericidal activity of both capsule- and lipopolysaccharide-specific antibodies. Meningococci have developed multiple strategies for changing capsule expression and structure, which is relevant both for colonization and virulence. Here we show that point mutations in the capsule synthesis genes substantially contribute to the repertoire of genetic mechanisms in natural populations leading to variability in capsule expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Ispasanie

Micoli²,

Lamelas

et al. 2018

Virulence

View full text Add to dashboard Cite

show abstract

“…Meningococcal disease has an annual incidence of one case per 100,000 population in Europe, marked by occurrence of outbreaks [6]. MenW has been known to be rare and to be associated with sporadic cases.…”

Section: Discussionmentioning

confidence: 99%

Meningococcal serogroup W and varicella-zoster virus meningitis in an Irish infant

Maduemem¹,

Vatca²,

Mohammed³

et al. 2018

Int J Case Rep Images

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.

show abstract

“…La portación o colonización del meningococo puede ser transitoria, pero en ocasiones poco frecuentes se desarrolla una enfermedad grave sistémica, que ocurre habitualmente dentro de los primeros 14 días posteriores a la colonización, y que puede evolucionar en períodos tan cortos como de un día. Los convivientes con un caso de EM, especialmente los hogareños, presentan un riesgo estimado de contagio ~800 veces mayor que el resto de la población 10 .…”

Section: Artículo Originalunclassified

Enfermedad meningocóccica: siempre presente. Cambios en los serogrupos en el Cono Sur

López

Debbag

2012

Rev. chil. infectol.

View full text Add to dashboard Cite

Epidemic meningitis, meningococcaemia, and Neisseria meningitidis

Cited by 852 publications

References 164 publications

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Meningococcal serogroup W and varicella-zoster virus meningitis in an Irish infant

Enfermedad meningocóccica: siempre presente. Cambios en los serogrupos en el Cono Sur

Contact Info

Product

Resources

About