Epidemic Genotype of<i>Coxiella burnetii</i>among Goats, Sheep, and Humans in the Netherlands

Tilburg, Jeroen J. H. C.; Roest, H.I.J.; Buffet, Sylvain; Nabuurs-Franssen, Marrigje H.; Horrevorts, A. M.; Raoult, Didier; Klaassen, Corné H. W.

doi:10.3201/eid1805.111907

Cited by 65 publications

(74 citation statements)

References 9 publications

(9 reference statements)

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“…The causative agent of the outbreak described here was an ST18 C. burnetii strain, which argues against a direct connection with the 2007-09 outbreak in the Netherlands which was caused primarily by ST33 [16,17]. ST18 has previously been detected in France, Germany, Italy, Romania and Slovakia [13].…”

Section: Discussionmentioning

confidence: 99%

Q fever epidemic in Hungary, April to July 2013

et al. 2014

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We investigated a Q fever outbreak with human patients showing high fever, respiratory tract symptoms, headache and retrosternal pain in southern Hungary in the spring and summer of 2013. Seventy human cases were confirmed by analysing their serum and blood samples with micro-immunofluorescence test and real-time PCR. The source of infection was a merino sheep flock of 450 ewes, in which 44.6% (25/56) seropositivity was detected by enzyme-linked immunosorbent assay. Coxiella burnetii DNA was detected by real-time PCR in the milk of four of 20 individuals and in two thirds (41/65) of the manure samples. The multispacer sequence typing examination of C. burnetii DNA revealed sequence type 18 in one human sample and two manure samples from the sheep flock. The multilocus variable-number tandem repeat analysis pattern of the sheep and human strains were also almost identical,

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Section: Discussionmentioning

confidence: 99%

Q fever epidemic in Hungary, April to July 2013

et al. 2014

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“…Molecular epidemiology can be used to identify the source of infection in animals and humans. During the Q fever epidemic that occurred in The Netherlands between 2007 and 2010, C. burnetii genotyping was successfully applied to identify isolates circulating in infected dairy goat farms and in human cases (13)(14)(15). Genotyping is also useful under nonepidemic conditions to obtain an inventory of the main strains circulating among livestock (16)(17)(18).…”

mentioning

confidence: 99%

“…The genotypic characterization of C. burnetii is of primary importance in the understanding of Q fever epidemiology (13). Indeed, it provides useful information about the strains circulating at the farm, region, or country level.…”

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confidence: 99%

Single Nucleotide Polymorphism Genotyping and Distribution of Coxiella burnetii Strains from Field Samples in Belgium

Pozzo

Renaville

Martinelle

et al. 2016

Appl Environ Microbiol

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The genotypic characterization of Coxiella burnetii provides useful information about the strains circulating at the farm, region, or country level and may be used to identify the source of infection for animals and humans. The aim of the present study was to investigate the strains of C. burnetii circulating in caprine and bovine Belgian farms using a single nucleotide polymorphism (SNP) technique. Direct genotyping was applied to different samples (bulk tank milk, individual milk, vaginal swab, fetal product, and air sample). Besides the well-known SNP genotypes, unreported ones were found in bovine and caprine samples, increasing the variability of the strains found in the two species in Belgium. Moreover, multiple genotypes were detected contemporarily in caprine farms at different years of sampling and by using different samples. Interestingly, certain SNP genotypes were detected in both bovine and caprine samples, raising the question of interspecies transmission of the pathogen.

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“…Coxiella burnetii in domestic animals, such as cattle, sheep, and goats, has been widely reported. [9][10][11][12] However, there is little detailed epidemiological data regarding the distribution and determinants of C. burnetii infection in rodents. Recent findings in Germany indicated regular sightings of wild rodents as risk factors for C. burnetii infection in humans, suggesting wild rodents as a direct source for human infection.…”

Section: Discussionmentioning

confidence: 99%

Coxiella burnetii in Rodents on Heixiazi Island at the Sino-Russian Border

Liu¹,

Xu²,

Fu³

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. This work is a molecular epidemiologic study to detect the incidence of Coxiella burnetii in rodents on Heixiazi Island at the Sino-Russian border of Heilongjiang Province. Liver tissues were extracted and processed to test the incidence of C. burnetii infection using polymerase chain reaction analysis. In total, 18% (66 of 370) of rodents tested positive for infection. The results of logistic regression analysis indicated that infection with C. burnetii was associated significantly with weight and month of capture, and infection was found in all rodent species that were observed; there was no significant difference of sex on the infection of C. burnetii. Though phylogenetic analysis disclosed heterogeneity in the nucleotide sequences isolated from the island rodents, the majority of observed strains were among the most common strains found worldwide. This is the first report on the incidence of C. burnetii in rodents on Heixiazi Island at the Sino-Russian border.

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Epidemic Genotype ofCoxiella burnetiiamong Goats, Sheep, and Humans in the Netherlands

Cited by 65 publications

References 9 publications

Q fever epidemic in Hungary, April to July 2013

Q fever epidemic in Hungary, April to July 2013

Single Nucleotide Polymorphism Genotyping and Distribution of Coxiella burnetii Strains from Field Samples in Belgium

Coxiella burnetii in Rodents on Heixiazi Island at the Sino-Russian Border

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