Epicutaneous induction of tolerance with acrylates and related compounds

Parker, Darien; Long, P.V.; Bull, J.; Turk, J.L.

doi:10.1111/j.1600-0536.1985.tb01084.x

Cited by 19 publications

(6 citation statements)

References 15 publications

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“…Dimethacrylates, according to Björkner (10) and Parker (11), have little sensitizing capacitiy when tested in guinea pigs, while Cavelier (12) has reported that EGDMA, DEGDMA, TREGDMA and TGGDMA are moderate allergens in the guinea‐pig maximization test. Several cases of contact allergy to EGDMA are described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Occupational contact allergy to (meth)acrylates

2001

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Among 13,833 patients suspected of contact dermatitis examined during the years 1978-1999, occupational contact allergy to (meth)acrylates was diagnosed in 31 patients. The 3 most common sensitizers were ethyleneglycol dimethacrylate (17 positive patch tests), 2-hydroxyethyl methacrylate (14) and triethyleneglycol dimethacrylate (6). The aim of this report was to assess the different occupations and industries responsible for occupational sensitization to (meth)acrylates. 14 of the 31 patients work in the dental sector, either as a dentist or as a student of dental technology, where (meth)acrylate-containing dental prostheses and dental composites are mainly responsible for allergy to (meth)acrylates. An increasing trend in dermatological problems related to the expansion of the use of (meth)acrylates is clearly reflected in the patient population of our dermatology department.

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Section: Discussionmentioning

confidence: 99%

Occupational contact allergy to (meth)acrylates

2001

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“…This ring will bear epitopes not present in either TMPTA or MeAc and it may exert an influ ence on the vinyl bond, which would render the bond nonantigenic in terms of antibodies raised against TMPTA/BGG or MeAc. Previously, we reported [8] that it is possible to elicit positive skin test responses to 4VP in guinea pigs sensitized to either TMPTA or MeAc, but that 4VP-sensitized animals only re sponded to a 4VP skin test. Therefore, it appears that cell-mediated immune responses in guinea pigs may involve recognition of different epitopes than does the humoral response.…”

Section: Discussionmentioning

confidence: 99%

“…1) have been in vestigated in terms of their immunogenicity as as sessed by the in vivo induction of antibody. The abil ity of the acrylates to induce antibodies and the spe cificities of these antibodies were compared with data published previously on the in vivo sensitization ca pacity and cross-reactivity between the acrylates [7,8].…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity of Acrylate Chemicals as Assessed by Antibody Induction

Bull

Henderson

Turk

1987

Int Arch Allergy Immunol

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The immunogenicities of two acrylate chemicals, trimethylolpropane triacrylate (TMPTA) and methyl acrylate (MeAc), and one related vinyl compound, 4-vinyl pyridine (4VP), were investigated by determining the in vivo induction of IgG antibodies in guinea pigs. The injection of the chemicals emulsified in Freund’s complete adjuvant resulted in the induction of serum antibody responses against MeAc and 4VP but not TMPTA. However, antibody with anti-TMPTA activity was produced following immunization of guinea pigs with TMPTA conjugated to protein, which allowed comparisons to be made of the immunogenic structural features of the compounds.

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“…Methyl acrylate caused sensitization in guinea pigs in various experimental systems [14,15]. In animal studies, methyl acrylate can also induce tolerance to sensitization with structurally related substances [15].…”

Section: Skin Sensitizationmentioning

confidence: 99%

“…In animal studies, methyl acrylate can also induce tolerance to sensitization with structurally related substances [15].…”

Section: Skin Sensitizationmentioning

confidence: 99%

Methyl acrylate [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 6 (1993) The article contains sections titled: Toxic Effects and Modes of Action Metabolism Effects in Man Effects on Animals Acute toxicity Skin irritation and corrosion Irritation of mucous membranes Skin sensitization Subacute and chronic toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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Epicutaneous induction of tolerance with acrylates and related compounds

Cited by 19 publications

References 15 publications

Occupational contact allergy to (meth)acrylates

Occupational contact allergy to (meth)acrylates

Immunogenicity of Acrylate Chemicals as Assessed by Antibody Induction

Methyl acrylate [MAK Value Documentation, 1993]

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