Epicondylitis after treatment with fluoroquinolone antibiotics

Huec, JC Le; Schaeverbeke, Thierry; Chauveaux, D.; Rivel, J; Dehais, J.; Rebeller, A. Le

doi:10.1302/0301-620x.77b2.7706350

Cited by 50 publications

(24 citation statements)

References 3 publications

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“…Other tendons like quadriceps tendon, rotator cuff tendon, as well as the site of tendon insertion may also be affected (there were two cases of epicondylitis reported after quinolone use). 5 Tendinitis was the commonest pathology, present in 83.7% of the cases. Tendon rupture occurred in about 40% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Fluoroquinolone-induced Achilles tendinitis

Tam

2014

Hong Kong Med J

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Section: Discussionmentioning

confidence: 99%

Fluoroquinolone-induced Achilles tendinitis

Tam

2014

Hong Kong Med J

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“…Tendonitis and spontaneous tendon rupture have been reported in humans and animals during or following therapy with fluoroquinolone antibiotics (Le Huec et al 1995;Lewis et al 1999;Van der Linden et al 2001Haddow et al 2003;Yu and Giuffre 2005). Fluoroquinolones have been known to affect the musculoskeletal systems of other species such as rats (Kato et al 1995;Kashida and Kato 1997).…”

Section: Discussionmentioning

confidence: 99%

The effects of enrofloxacin on canine tendon cells and chondrocytes proliferation in vitro

et al. 2007

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Enrofloxacin, a fluoroquinolone antibiotic has been used widely in humans and domestic animals, including dogs, because of its broad-spectrum activity and relative safety. The side effects of fluoroquinolone, induced tendinopathy, tendonitis, spontaneous tendon rupture and cartilage damage, remain incompletely understood. In the present study, we investigated the in vitro effects of enrofloxacin on cell proliferation and induction of apoptosis in canine Achilles tendon cells and chondrocytes. Cell growth and proliferation after treating with enrofloxacin for 2-6 days was quantified by a colorimetric 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxyanilide inner salt (XTT) assay. The results showed that enrofloxacin could inhibit the proliferation of canine tendon cells and chondrocytes at increasing concentrations (10-200 microg/ml). The inhibition of proliferation of canine tendon cells and chondrocytes after exposure to enrofloxacin were associated with induction of apoptosis, as evidenced by the typical nuclear apoptotic condensed nuclei found using Hoechst 33258 staining. It was demonstrated that canine tendon cells and chondrocytes treated with 200 microg/ml enrofloxacin for 4 days exhibited apoptotic features and fragmentation of DNA. Enrofloxacin also increased the apoptosis of canine tendon cells and chondrocytes in a dose and time-dependent manner. The results indicate that enrofloxacin inhibits cell proliferation, induces apoptosis and DNA fragmentation, which might explain enrofloxacin-induced tendinopathy and cartilage damage.

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“…Tendons are connective tissue structures with a low cell content, mainly fibroblasts, little vascularity, and are primarily composed of collagen fibres [6]. The diminishing vascularity of the Achilles tendon with advancing age [7] and steroid use [8] has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Achilles tendon disease in lung transplant recipients: association with ciprofloxacin

Pn¹,

Ml²,

Pm³

et al. 2002

European Respiratory Journal

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Achilles tendon disease in lung transplant recipients: association with ciprofloxacin. P.N. Chhajed, M.L. Plit, P.M. Hopkins, M.A. Malouf, A.R. Glanville. #ERS Journals Ltd 2002. ABSTRACT: Achilles tendonitis or rupture are uncommon complications following the use of fluoroquinolones, with a reported incidence in the general population of 0.4%. The aims of the current study were to determine the incidence of Achilles tendon disease (ATD) in lung transplant recipients (LTR) and to identify risk factors.Questionnaires were sent to 150 LTR of whom 101 responded (67%). Twenty-two LTR (21.8%) experienced ATD (tendonitis 16, rupture six). The mean age of LTR who developed ATD was 52.9 ¡ 6.1 yrs (range: 19-63.5 yrs).Only the use of ciprofloxacin was significantly associated with ATD (pv0.05). Age, sex, underlying disease necessitating transplantation, serum creatinine and cyclosporine levels were not associated with ATD. The association between ciprofloxacin and ATD was not dose related. Of the 72 LTR who had received ciprofloxacin, 20 (28%) developed ATD (tendonitis 15, rupture five). In patients receiving ciprofloxacin, there was no association between the mean cumulative dose of prednisolone and ATD. Tendon rupture occurred with a lower ciprofloxacin dosage than tendonitis and the mean recovery duration was significantly longer.To conclude, lung transplant recipients receiving ciprofloxacin are at significant risk of developing Achilles tendon disease. The association between ciprofloxacin and Achilles tendon disease appears to be idiosyncratic rather than dose-related.

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Epicondylitis after treatment with fluoroquinolone antibiotics

Cited by 50 publications

References 3 publications

Fluoroquinolone-induced Achilles tendinitis

Fluoroquinolone-induced Achilles tendinitis

The effects of enrofloxacin on canine tendon cells and chondrocytes proliferation in vitro

Achilles tendon disease in lung transplant recipients: association with ciprofloxacin

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