Epichlorohydrin-Cross-linked Hydroxyethyl Cellulose/Soy Protein Isolate Composite Films as Biocompatible and Biodegradable Implants for Tissue Engineering

Zhao, Yanteng; He, Meng; Zhao, Lei; Wang, Shiqun; Li, Yinping; Gan, Li; Li, Mingming; Xu, Li; Chang, Peter R.; Anderson, Debbie P.; Chen, Yun

doi:10.1021/acsami.5b11152

Cited by 121 publications

(86 citation statements)

References 48 publications

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“…The typical polysaccharides are alginate, hyaluronic acid (HA), agarose, chitosan, dextran, cellulose, pectin, gellan, and heparin . Polysaccharides with fast gelation properties are appropriate for the fabrication of complex 3D scaffolds with various morphologies, such as microfibers, microspheres, membranes, and defined blocks, thus providing architectural cues for tissue/organ constructs in vitro. The natural proteins used as cell culture matrices are collagen, gelatin, fibrin, silk protein (mainly referring to silk fibroin), poly‐ l ‐lysine (PLL), and soy protein .…”

Section: Snapshot Of Hydrogelsmentioning

confidence: 99%

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

et al. 2019

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The major motivation is to better mimic human physiology and functions at multiscales from the molecular to the cellular, tissue, organ or even whole organism level. Current model systems primarily rely on the monolayer cell cultures and animal models. Simplistic monolayer cultures have their advantages, but they are often significantly different in gene expression, epigenetics, and cell function compared to native 3D tissues. [1,2] Also, they often lack cell-cell and cell-matrix interactions, [2,3] leading to the absence of tissue specific properties. Although animal models are widely used in biomedical research, they fail to faithfully predict human responses in a physiologically relevant manner due to the significant species divergences. [4] The limitations of these systems have provided an impetus for the development of alternative cell-based 3D models in vitro that better resemble the complex functionalities of living organs. Over the last several years, organoids and organ-on-a-chip (OOC), representing the major technological breakthrough, have emerged as two distinct model systems to achieve the same goal of building 3D organotypic models in vitro by bridging the gap between animal models and monolayer cultures. These engineered models are different in terms of cell source, tissue composition, architectural variability, functional features, scales, cellular fidelity, etc. Organoids, primarily evolving from developmental principles, refer to 3D multicellular tissues by self-organization of stem cells or organ-specific progenitors, which can recapitulate the intricate architectures and functionalities of in vivo organs. [5][6][7] Recent breakthroughs in organoid technology have enabled the successful generation of a variety of human organoids, such as the brain, [8,9] intestine, [10,11] liver, [12] kidney, [13,14] lung, [15] etc. These near physiological 3D organoids have garnered momentum for their potential applications in human organ development and disease modeling, drug screening and regenerative medicine. The explosion of organoids research has been catalyzed by the significant progress of stem cell biology and availability of human stem cells. In contrast, the OOC, relying on the bioengineering design principle, is a miniaturized in vitro model that can recreate the functional units of living organs on a microfluidic cell culture device using predifferentiated cells, often cell lines. [1,16] The OOC is primarily evolved from the convergence of tissue engineering and microfabricated technologies, which is characterized by the capability to simulate cellular microenvironment by precise control over fluid flow, mechanical forces and biochemical factors. [4,17] Remarkable progress has been made Significant advances in materials, microscale technology, and stem cell biology have enabled the construction of 3D tissues and organs, which will ultimately lead to more effective diagnostics and therapy. Organoids and organs-on-a-chip (OOC), evolved from developmental biology and bioengineering principles, have e...

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Section: Snapshot Of Hydrogelsmentioning

confidence: 99%

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

et al. 2019

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“…The incorporated PU elastomer blue‐shifts the peak of SP at 1644–1650 cm −1 in the SP‐PU, as the newly formed intermolecular hydrogen bonds between the SP and PU partly break the intramolecular hydrogen bonds within the SP matrix . In addition, it is observed that a new peak appears at 1106 cm −1 , and the absorption intensities of the peaks around 1391 (COO bending) and 1446 cm −1 (NH blending) also increase, which all indicate that the PU induces crosslinking reactions and forms multiple hydrogen bonds with the SP molecules thus influencing the chemical environment of the SP functional groups . After incorporating the D‐PU elastomer, the intensity of the peaks at 1515, 1645, and 3278 cm −1 decrease, which is mainly because that the catechol OH of D‐PU further forms strong physical intermolecular interactions with the OH and amide groups of the SP molecules .…”

Section: Resultsmentioning

confidence: 93%

“…After incorporating the D‐PU elastomer, the intensity of the peaks at 1515, 1645, and 3278 cm −1 decrease, which is mainly because that the catechol OH of D‐PU further forms strong physical intermolecular interactions with the OH and amide groups of the SP molecules . Moreover, another new characteristic peak appears at 1370 cm −1 (CN stretching) in the SP‐D‐PU spectra, evidently demonstrating that the catechol of D‐PU induces the PU to further react with the SP matrix by means of Schiff base reactions …”

Section: Resultsmentioning

confidence: 94%

Designing Biomimetic Microphase‐Separated Motifs to Construct Mechanically Robust Plant Protein Resin with Improved Water‐Resistant Performance

Zhao

Zhong

Pang

et al. 2020

Macro Materials & Eng

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Plant protein, as a sustainable alternative to petroleum‐derived resin, has exhibited notable potential for engineering wood products without formaldehyde emission, while the poor mechanical and water‐resistant performances limit its practical applications. Inspired by mussel chemistry and structure, a dopamine‐functionalized polyurethane (D‐PU) elastomer is synthesized in this work acting as a bio‐inspired crosslinking unit to improve the properties of soy protein (SP) resin. It is found that the catechol groups of the incorporated D‐PU not only triggers polyurethane to interact with SP matrix giving rise to a stable crosslinking network with excellent load‐bearing capacity, but also serves as a water‐resistant barrier to reduce the water erosion effect on resin. Moreover, a desired microphase‐separated morphology is observed within the continuous protein phase after introducing D‐PU. The microphase‐separated structure simultaneously strengthens and toughens SP adhesive layer, thus achieving high‐efficiency stress transfer and energy dissipation as well as accelerating SP to further permeate into the substrate forming more mechanical adhesion nails. As a result, the modified SP‐D‐PU resin presents an impressive improvement in dry and wet adhesion strength up to 70.5% and 133.9% compared to the pristine SP resin, respectively. The proposed biomimetic design may offer a workable strategy for preparing of high‐performance bio‐based composites.

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“…With an increase of worldwide environmental pollution caused by nonbiodegradable polymers and the impact of growing petroleum crisis, the research and development of biodegradable materials from renewable resources, including cellulose, starch, lignin, chitin, chitosan, vegetable oil, and protein have attracted much attention. Among those natural products, soy oil might be the most suitable one to be used in synthesizing polymers, especially polyurethane, because of its good solubility, excellent miscibility, low cost, high output, and easy to modify.…”

Section: Introductionmentioning

confidence: 99%

Recyclable, shape‐memory, and self‐healing soy oil‐based polyurethane crosslinked by a thermoreversible Diels–Alder reaction

Zheng

Tian

Fan

et al. 2017

J of Applied Polymer Sci

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The recyclable, shape-memory, and self-healing soy oil-based polyurethane (S-PU) networks were constructed by the thermoreversible Diels-Alder (DA) reaction between S-PU (sealed with furfuryl alcohol) and 1,5-bis(maleimido)-2-methylpentane. The DA and retro-DA reactions between furan and maleimide were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, solubility, and recycle testing. Moreover, the shape-memory properties of the S-PU networks were studied by qualitative recovery testing and quantitative cyclic tensile testing. Furthermore, the self-healing properties of S-PU networks were confirmed by cut, scratch, and tensile testing. The results showed that, compared to the traditional S-PU, the novel S-PU prepared in this work was recyclable and self-healing. And although both of them have shape-memory effect, the novel S-PU has a higher shape fixed rate and shape recovered rate than the traditional S-PU.

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Epichlorohydrin-Cross-linked Hydroxyethyl Cellulose/Soy Protein Isolate Composite Films as Biocompatible and Biodegradable Implants for Tissue Engineering

Cited by 121 publications

References 48 publications

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

Designing Biomimetic Microphase‐Separated Motifs to Construct Mechanically Robust Plant Protein Resin with Improved Water‐Resistant Performance

Recyclable, shape‐memory, and self‐healing soy oil‐based polyurethane crosslinked by a thermoreversible Diels–Alder reaction

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