Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo

Methanolic Extract of Clinacanthus nutans Leaves can Alter Adipocyte Cellularity, Inflammation and Acetyl Cholinesterase Activity in Male Obese Mice

“…Similar results were observed in mice supplemented with blueberries [54]. In addition, polyphenols, anthocyanin and catechin prevented inflammation by inhibiting nuclear factor kappa-light-chain-enhancer of activated NFB activity [55][56][57]. Indeed, as recently highlighted by de Melo et al [58] showed that oleanolic acid a natural triterpenoid when administered daily (50 mg/L in drinking water), to HFD fed adult male Swiss mice for 15 weeks, they confirmed that the triterpene, oleanolic acid (OA) has been described to decrease the IL-6 production.…”

(‐)‐Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high‐fat diet

“…In experimental and clinical studies, inflammatory markers such as C-reactive protein, tumor necrosis factor-alpha, interleukin 6 and nu-clear factor kappa-␤, are associated with lipids level [39]. EC has been shown to reduce chronic inflammation in various animal models and under various conditions [17,[40][41][42][43][44]. In current study, EC was found to significantly reduce IL-1beta, IL-2 and IL-6 in hyperlipidemic rats, with is in line with previous reports.…”

LPS-induced renal inflammation is prevented by (−)‐epicatechin in rats

“…Epidemiological and experimental data demonstrate that dietary flavonoids and their metabolites contribute to the prevention and/or amelioration of the risk factors for cardiometabolic diseases [13], [14], [15]. Many in vitro and in vivo studies in various tissues support the anti-inflammatory effects of the flavanol (−)-epicatechin by attenuating the activation of the NF-κB signaling pathway [16], [17], [18], [19].…”