Epicardial neural ganglionated plexus of ovine heart: Anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

Saburkina, Inga; Rysevaitė, Kristina; Paužienė, Neringa; Mischke, Karl; Schauerte, Patrick; Jalife, José; Pauža, Dainius Haroldas

doi:10.1016/j.hrthm.2010.02.036

Cited by 61 publications

(68 citation statements)

References 30 publications

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“…This is not a declaration that these neuronal markers are co-localizing within individual fibers, but our data so suggest that at a macroscopic level, that AChE can be considered a non-specific cholinergic marker. This is in accordance with other studies (Rysevaite et al, 2011;Saburkina et al, 2010). These data strongly implie that a number of investigators (Crick et al, 1996;Hoover et al, 2004;Kawano et al, 2003;Otake et al, 2009) may be incorrect in their conclusion that the occurrence of AChE in peripheral nerves is a specific marker for cholinergic innervation.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures

Pauža

Rysevaitė-Kyguolienė

Vismantaite

et al. 2014

Annals of Anatomy - Anatomischer Anzeiger

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Section: Discussionsupporting

confidence: 89%

“…A comparison of AChE stained whole-mount material, along with the corresponding microtome sectioned AChE stained/immunohistochemically processed sections from the left dorsal subplexus region in the sheep ventricle (Saburkina et al, 2010) is illustrated in Fig. 3.…”

Section: Resultsmentioning

confidence: 99%

A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures

Pauža

Rysevaitė-Kyguolienė

Vismantaite

et al. 2014

Annals of Anatomy - Anatomischer Anzeiger

Self Cite

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“…Furthermore, studies on the sympathetic nervous system have been divided into the following two types: research on the proximal part from the spinal nerves to the sympathetic ganglia (Axford 1927(Axford -1928Becker and Grunt 1957;Harman 1900;Hoffman 1957;Jamieson et al 1952;Kuntz 1946;Mitchell 1953;Pick and Sheehan 1946;White and Smithwick 1952;Wrete 1959), and research on the distal part from the sympathetic ganglia to the visceral nerves (Ellison and Williams 1962;Fukuyama 1982;Hausman 1956;Janes et al 1986;Kuntz and Morehouse 1930;Mizeres 1963;Mitchell 1953;Pick 1970). Although a few excellent anatomical studies on the ACNS have been conducted recently (Batulevicius et al 2003(Batulevicius et al , 2005Pauza et al 2000Pauza et al , 2002Saburkina et al 2010;Tanaka et al 1998Tanaka et al , 2007, numerous points remain to be clarified regarding future human applications.…”

Section: Introductionmentioning

confidence: 99%

Anatomy of the cardiac nervous system with clinical and comparative morphological implications

Kawashima

2010

Anat Sci Int

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Unlike autonomic nervous preservation in other surgeries for improving patient quality of life, autonomic cardiac nervous system (ACNS) preservation has been neglected in cardiovascular surgery because of technical difficulties and other unsolved issues. Because such ACNS preservation in cardiovascular surgery is anticipated in the future, detailed anatomical investigation of the human ACNS is required. Therefore, we have conducted morphological studies of the ACNS from macroscopic, clinical, and evolutionary anatomical viewpoints. In this study, I review detailed anatomical studies of the human ACNS together with their clinical implications. In addition, the evolutionary comparative anatomical significance of primate ACNS is also summarized to help understand and translate the findings of functional experiments to humans. These integrated findings will be the subject of a future study unifying molecular embryological and anatomical findings to clarify cardiac functions based on functional animal experiments, clinical applications such as improving surgery techniques and individual order-made surgery in cardiac surgery, and for future evaluation in regenerative medicine.

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“…Dense parasympathetic innervation is demonstrated in all species studied including the mouse (Rysevaite et al 2011), guinea pig (Batulevicius et al. 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2005), rabbit (Pauziene et al 2016), cat (Johnson et al 2004, dog (Pauza et al 2002), pig (Ulphani et al 2010), sheep (Saburkina et al 2010) and human ventricle (Pauza et al 2000;Kawano et al 2003).…”

Section: The Parasympathetic Nervous System and Ventricular Arrhythmiasmentioning

confidence: 99%

Neuro-cardiac interaction in malignant ventricular arrhythmia and sudden cardiac death

2016

Autonomic Neuroscience

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Sudden cardiac death as a result of lethal ventricular arrhythmias is a major cause of death in cardiac diseases such as heart failure and prior myocardial infarct. Activity of the autonomic nervous system is often abnormal where sympathetic activity is upregulated and vagal activity reduced in these conditions. The abnormal autonomic state has been shown to be a strong prognostic marker of increased mortality and propensity to lethal arrhythmias, for which there is no effective prevention. Research effort over the years has established good evidence for a causal link between autonomic disturbance and ventricular arrhythmias. However, the detailed electrophysiological mechanisms by which ventricular fibrillation occurs are still not clear and molecular processes which are modulated by autonomic nerve influences that either predispose the heart to or protect it from these arrhythmias are not fully understood. This review presents data from studies investigating the link between activity of the autonomic nervous system and ventricular arrhythmias, from seminal findings in classical studies to ongoing investigations, in the quest for a better understanding of the arrhythmogenic mechanisms underlying neurocardiac interactions with a view to the development of effective preventative and therapeutic strategies which are very much needed.

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Epicardial neural ganglionated plexus of ovine heart: Anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

Abstract: SummaryBACKGROUND-The sheep is routinely used in experimental cardiac electrophysiology and surgery.

Cited by 61 publications

References 30 publications

A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures

A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures

Anatomy of the cardiac nervous system with clinical and comparative morphological implications

Neuro-cardiac interaction in malignant ventricular arrhythmia and sudden cardiac death

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