Epicardial fat tissue thickness is correlated with diminished levels of co-enzyme Q10, a major antioxidant molecule among hemodialysis patients

Macunluoğlu, Beyza; Atakan, Aydın; Arı, Elif; Kaya, Yüksel; Kaspar, Çiğdem; Demır, Halit; Hakan, Hamit

doi:10.1016/j.clinbiochem.2014.05.057

Cited by 14 publications

(23 citation statements)

References 29 publications

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“…Plasma CoQ10 levels have been reported to be significantly lower in CKD patients (with or without haemodialysis), compared to normal controls (Triolo et al, 1994;Macunluoglu et al, 2014;Yeung et al, 2015). The cause of this deficit in serum CoQ10 levels is as yet uncertain, however, it may be associated with the increased oxidative stress reported in CKD (Oberg.et al, 2004).…”

Section: Coq10 and Kidney Function In Ckdmentioning

confidence: 99%

Chronic kidney disease and coenzyme Q10 supplementation

Hargreaves

Mantle²,

Milford

2019

Journal of Kidney Care

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Section: Coq10 and Kidney Function In Ckdmentioning

confidence: 99%

Chronic kidney disease and coenzyme Q10 supplementation

Hargreaves

Mantle²,

Milford

2019

Journal of Kidney Care

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“…Oxidative stress is another mechanism responsible for increased risk other than infiltration. Previous studies have shown a positive correlation between EFT and serum oxidant content and a negative correlation with anti oxidant content (16)(17).…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Epicardial Fat and Carotid and Femoral Intima-Media Thicknesses in Geriatric Patients With End-Stage Renal Disease

Güneşli¹,

Yılmaz²,

Yalçin³

et al. 2020

tjgeri

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Although atherosclerotic cardiovascular diseases and cardiovascular risks are known to increase in patients with end-stage renal disease, it is not clear whether these risks increase in the geriatric patient population as well. This study aims to evaluate these risks in geriatric patients with end-stage renal disease by evaluating epicardial fat and carotid and femoral intima-media thicknesses, known as markers, for subclinical atherosclerosis and cardiovascular risks. Materials and Methods: This cross-sectional study included 52 patients who started to receive chronic hemodialysis treatment after the age of 65 years (mean age 73.92±5.63) years with end-stage renal failure and 51 healthy volunteers (mean age: 74.49±4.63 years). Epicardial fat and carotid and femoral intima-media thicknesses were measured and compared between these groups. Results: Carotid intima-media and epicardial fat thicknesses were significantly higher in the patient group than in the control group (0.91±0.08 vs. 0.71±0.1 mm, p<0.001 and 0.84±0.17 vs. 0.75±0.17 cm, p=0.01, respectively). However, no significant difference was observed in femoral intima-media thickness between the two groups (0.58±0.07 vs. 0.56±0.97 mm, p=0.266). Correlation analysis revealed a significant positive correlation between the duration of dialysis and epicardial fat and carotid intima-media thicknesses (r=0.611, p<0.001 and r=0.337, p=0.015, respectively). Furthermore, regression analysis revealed a significant relationship between the duration of dialysis and carotid intima-media thickness (β=0.657, p=0.001). Conclusion: Epicardial fat and carotid intima-media thicknesses increase in geriatric patients with end-stage renal disease but with no significant changes in femoral intima-media thickness, indirectly suggesting that subclinical atherosclerosis and cardiovascular risks are increased in these patients.

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“…Recently its influence has been suggested in pathogenesis of both cardiovascular and extracardiac disorders [1][2][3][4][5][6][7]. The correlations demonstrated to date include a broad spectrum of pathologies such as sleep apnea [4] amongst others [5][6][7].…”

Section: Introductionmentioning

confidence: 97%