Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia

Ertem, Ahmet Göktuğ; Erdoğan, Mehmet; Köseoğlu, Cemal; Akoğlu, Gülşen; Özdemir, Elçin; Koseoglu, Gamze; Sivri, Serkan; Keleş, Telat; Durmaz, Tahir; Aktaş, Akın; Bozkurt, Engin

doi:10.1016/j.repc.2016.04.010

Cited by 14 publications

(6 citation statements)

References 32 publications

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“…EFT has an inflammation-inducing effect through the secretion of proinflammatory molecules such as IL-1β, IL-6, tumor necrosis factor (TNF)-α, leptin, plasminogen activator inhibitor-1 and monocyte chemoattractant protein-1 like cytokines [17][18][19]. In this regard, EFT is shown to be increased in psoriasis and lichen planus, compared to the control group, in recent studies [10,11]. SD is seen 2-4 times more frequently than psoriasis and lichen planus in the population [27].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that EFT is increased in chronic inflammatory skin diseases such as psoriasis and lichen planus, and is associated with some cardiometabolic parameters in these patients [10,11]. However, no studies to date have investigated EFT in the setting of SD, despite it has been previously shown to be associated with MetS and dyslipidemia [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Epicardial Fat Thickness Increase in Patients With Seborrheic Dermatitis as a Clinical Biomarker of Cardio-Metabolic Risk

Kaya¹,

Kaya²

2023

hpc

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Background. Seborrheic dermatitis (SD) can be associated with cardiometabolic conditions. This study aimed to evaluate epicardial fat thickness (EFT), a marker of cardiometabolic disease, in SD patients. Material and methods. In this cross-sectional and observational study, 90 patients with SD and 50 age-and sex-matched control subjects were evaluated for echocardiographic EFT and metabolic profile data. Results. Systolic blood pressure, heart rate, high sensitive C-reactive protein, monocyte count and EFT were found to be significantly higher in the SD group (53 female; mean age, 39.3±13.3 years) compared to the control group (34 female; mean age, 39.9±13.4 years). In the multivariate logistic regression analysis, the EFT and heart rate were found to be independently associated with SD. Additionally, in the multivariate linear regression analysis including the parameters correlated with EFT and the parameters associated with EFT at the p<0.001 level in univariate analysis; BMI (β: 0.341, p<0.001) and SD disease duration (β: 0.435, p<0.001), as well as seborrheic dermatitis area and severity index (β: 0.177, p=0.037) were found to be independently associated with EFT. Conclusions. EFT is increased in patients with SD and was also found to be independently associated with SD. Prolonged and severe SD may be a dermatological sign regarding cardiometabolic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epicardial Fat Thickness Increase in Patients With Seborrheic Dermatitis as a Clinical Biomarker of Cardio-Metabolic Risk

Kaya¹,

Kaya²

2023

hpc

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“…The systemic infl ammation response-based indexes, such as neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were defi ned as an indicator for lichen planus (12,13). Recently, the fi brinogen to albumin ratio (FAR) has been studied as an effective indicator for some cardiovascular diseases, infl ammatory diseases, and malignancies (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Measurement of epicardial fatty tissue thickness has a diagnostic value in lichen planus patients and is associated with fibrinogen to albumin ratio and neutrophil to lymphocyte ratio

Tosun¹,

Opan²,

An³

2023

BLL

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OBJECTIVE: Lichen planus (LP) is one of the chronic infl ammatory diseases. Epicardial fatty tissue (EFT) is the adipose tissue in which pro-infl ammatory and pro-atherogenic hormones and cytokines are secreted. We planned to investigate the predictive value of EFT in LP patients by evaluating together with Fibrinogen to albumin ratio (FAR) other infl ammation markers. MATERIALS AND METHODS: A total of 53 consecutive LP patients and 57 healthy controls were enrolled in this single-center, prospective, case-control study. Demographic data were recorded; blood tests were obtained from both groups. Then, EFT thickness was measured by echocardiography. RESULTS: Fibrinogen, FAR, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, and EFT thickness were higher in LP patients (p < 0.05, for all). EFT was positively correlated with FAR (r = 0.306, p = 0.001), NLR (r = 0.240, p = 0.011), and PLR (r = 0.297, p = 0.002). ROC analysis indicated that FAR could predict LP with a sensitivity of 83 % and a specifi city of 44 %; NLR could predict LP with a sensitivity of 80 % and a specifi city of 46 %; EFT could predict LP with a sensitivity of 79 % and a specifi city of 54 %. In the binary logistic regression analysis NLR, FAR, and EFT were found to be independent predictors of LP. CONCLUSION: We found a relationship between LP and FAR together with other infl ammation parameters NLR, and PLR. We demonstrated for the fi rst time that FAR, NLR and EFT were independent predictors of LP. Also, there was a signifi cant relationship between these parameters and EFT (Tab. 4, Fig. 1, Ref. 30).

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“…The pathogenesis of LP and these cardiovascular disorders have been linked with chronic inflammation and the induction of oxidative stress. [21011] Studies have shown an association between LP, dyslipidemia,[234589] impaired glucose tolerance,[12] arrhythmias,[13] hypertension, atherosclerosis,[1415] and MetS. [69] More recently, evidences are increasing on the association between LP, subclinical chronic inflammation, and entities such as carotid media intima thickness and epicardial fat thickness.…”

Section: Introductionmentioning

confidence: 99%

“…[69] More recently, evidences are increasing on the association between LP, subclinical chronic inflammation, and entities such as carotid media intima thickness and epicardial fat thickness. [14151617] The prevalence of MetS, dyslipidemia, and their association with LP varies in published studies. [2345678910] Only a few published studies on MetS and dyslipidemia in LP in the available literature originated from Africa.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and dyslipidemia among Nigerians with lichen planus: A cross-sectional study

et al. 2019

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Background: Lichen planus (LP) is an inflammatory skin disease of unknown etiology associated with chronic inflammation, oxidative stress induction, and cardiovascular risk factors. Objectives: To document the prevalence of metabolic syndrome (MetS), dyslipidemia, and associated factors in Nigerian patients with LP. Methods: A cross-sectional design was made to evaluate 90 patients with LP and 90 controls for MetS and dyslipidemia in two Nigerian teaching hospitals. Diagnosis of LP was made with the aid of histology, and MetS and dyslipidemia were diagnosed using the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: The prevalence of MetS was insignificantly higher in LP than in control (18.9% vs. 13.5, P = 0.311), and dyslipidemia was significantly associated with LP (60% vs. 40%, P = 0.007). LP was associated with higher mean of serum triglyceride (1.21 ± 0.34 vs. 1.08 ± 0.32 mmol/L, P = 0.003), low-density lipoprotein cholesterol (3.47 ± 0.89 vs. 3.12 ± 0.77 mmol/L, P = 0.007), and T-cholesterol (5.32 ± 0.88 vs. 4.92 ± 0.86, P = 0.002). LP patients with MetS were older ( P < 0.001) and less likely to have Wickham's striae ( P = 0.028) compared to those without MetS. Female LP patients were older ( P = 0.047), obese ( P = 0.043), and had insignificant increase in MetS prevalence compared to the males. Hypertrophic LP was more frequent in patients with dyslipidemia (63.0% vs. 27.8%, P = 0.002), and the family history of diabetes mellitus (DM) was an independent predictor of MetS in LP patients (odds ratio: 4.4, confidence interval: 1.0–19.1, P = 0.047). Limitation: Availability of fund is a significant factor that limited the sample size to the minimum required as always in a poor-resource setting. Conclusions: LP has an insignificant association with MetS and a significant association with dyslipidemia among Nigerians. The family history of DM is an independent predictor of MetS in LP patients. LP patients should be routinely screened for MetS and its components.

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Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia

Abstract: EFT is increased in patients with LP compared to control subjects. Duration of LP is correlated with EFT, and duration of LP is also an independent predictor of increased EFT, which is a predictor of subclinical atherosclerosis.

Cited by 14 publications

References 32 publications

Epicardial Fat Thickness Increase in Patients With Seborrheic Dermatitis as a Clinical Biomarker of Cardio-Metabolic Risk

Epicardial Fat Thickness Increase in Patients With Seborrheic Dermatitis as a Clinical Biomarker of Cardio-Metabolic Risk

Measurement of epicardial fatty tissue thickness has a diagnostic value in lichen planus patients and is associated with fibrinogen to albumin ratio and neutrophil to lymphocyte ratio

Metabolic syndrome and dyslipidemia among Nigerians with lichen planus: A cross-sectional study

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