Epicardial adipose tissue, metabolic disorders, and cardiovascular diseases: recent advances classified by research methodologies

Song, Yujie; Tan, Yanzhen; Deng, Meng; Shan, Wenju; Zheng, Wenying; Zhang, Bing; Cui, Jun; Feng, Lele; Shi, Lei; Zhang, Miao; Liu, Yingying; Sun, Yang; Yi, Wei

doi:10.1002/mco2.413

Cited by 5 publications

(1 citation statement)

References 232 publications

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“…The potential role of EAT as a source of stem cells, as well as imaging assessment, was also described. Due to its unique structure and features, the role of EAT has drawn researchers' attention in terms of metabolic and cardiovascular (CV) disorders [15], including coronary artery disease (CAD) [16,17], heart failure (HF) [18], or atrial fibrillation (AF) [19]. Most research concerns the relationship between adipose tissue and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

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Section: Introductionmentioning

confidence: 99%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Tessuto adiposo epicardico: dagli aspetti biomolecolari alla pratica clinica

Malavazos,

Dubini,

Meregalli

et al. 2024

L'Endocrinologo

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SommarioIl tessuto adiposo epicardico (EAT) è un fattore di rischio cardiovascolare in quanto promuove la progressione della fibrillazione atriale, della malattia coronarica e dell’insufficienza cardiaca. EAT si caratterizza per rapido metabolismo, misurabilità clinica e facile modificabilità e rappresenta un bersaglio terapeutico peculiare per farmaci innovativi, quali gli agonisti del recettore del peptide glucagone-simile 1 e gli inibitori del co-trasportatore sodio-glucosio 2, che appaiono salutari dal punto di vista cardiometabolico ben oltre i loro effetti sul glucosio e sul peso corporeo (Materiale Supplementare).

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Optimal cut-off points of anthropometric and body roundness indices associated with diabetes: Persian (Shahedieh) cohort study

Ghomi,

Sefidkar,

Khaledi

et al. 2024

Front. Nutr.

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IntroductionDiabetes is a chronic and concerning health condition that poses a significant public health challenge. Given that preventing, detecting early, and treating T2DM can enhance public health outcomes, the objective of this study was to identify the most effective obesity indices and determine their optimal cut-off points for predicting the risk of T2DM in an Iranian population.MethodsThis study was conducted on 8,019 male and female participants aged between 35 and 70 years in the context of Shahedieh cohort study. The ROC curve analysis was utilized to determine the optimal cut-off point of each anthropometric index to predict diabetes in age-sex categories.ResultsThe overall diabetes incidence in the study population was 2.5%, with 2.5% in men and 2.4% in women. In men, significant differences in most of the anthropometric indices were observed between diabetic individuals and healthy counterparts. This study found that for women 45–65, BMI and weight, and for men under 65 years, weight, WHR, BMI, WC, WHTR, AVI, and BRI are efficient T2DM predictors. The AUC of these indices varied from 0.593 (95% CI: 0.510–0.676) to 0.668 (95% CI: 0.586–0.750) in men, and from 0.587 (95% CI: 0.510–0.664) to 0.644 (95% CI: 0.535–0.754) in women.ConclusionAnthropometric indices and body roundness are simple, inexpensive, and noninvasive means markers to predict the risk of diabetes. Our findings show that most of the studied indices had acceptable prediction power for men except for elderly. For women over 45 years old, weight and BMI are appropriate predictors. It seems that the approach of reducing diabetes incidence through early detection and primary prevention is achievable.

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Epicardial adipose tissue, metabolic disorders, and cardiovascular diseases: recent advances classified by research methodologies

Cited by 5 publications

References 232 publications

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Tessuto adiposo epicardico: dagli aspetti biomolecolari alla pratica clinica

Optimal cut-off points of anthropometric and body roundness indices associated with diabetes: Persian (Shahedieh) cohort study

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