Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer

Qiao, Zhen; Liao, Min; Xiao, Mingyue; Luo, Saiyan; Wang, Kexin; Niu, Mengxin; Jiang, Honglv; Sun, Suya; Xu, Guoqiang; Xu, NanJie; Xu, Qiongming; Liu, Yanli

doi:10.1016/j.bcp.2023.116004

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…Eph/ephrin proteins are implicated in numerous chronic inflammatory conditions. Targeting EPHB4 to disrupt EphB/ephrin B signaling holds potential as a pharmacological strategy for treating UC ( 50 ). In summary, the involvement of Eph/ephrin signaling in maintaining intestinal balance, managing inflammation, and regulating neuroimmune interactions offers exciting possibilities for future investigations and therapeutic advancements in gastrointestinal conditions ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

Deciphering the shared mechanisms of Gegen Qinlian Decoction in treating type 2 diabetes and ulcerative colitis via bioinformatics and machine learning

Hu,

Xiong,

et al. 2024

Front. Med.

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BackgroundAlthough previous clinical studies and animal experiments have demonstrated the efficacy of Gegen Qinlian Decoction (GQD) in treating Type 2 Diabetes Mellitus (T2DM) and Ulcerative Colitis (UC), the underlying mechanisms of its therapeutic effects remain elusive.PurposeThis study aims to investigate the shared pathogenic mechanisms between T2DM and UC and elucidate the mechanisms through which GQD modulates these diseases using bioinformatics approaches.MethodsData for this study were sourced from the Gene Expression Omnibus (GEO) database. Targets of GQD were identified using PharmMapper and SwissTargetPrediction, while targets associated with T2DM and UC were compiled from the DrugBank, GeneCards, Therapeutic Target Database (TTD), DisGeNET databases, and differentially expressed genes (DEGs). Our analysis encompassed six approaches: weighted gene co-expression network analysis (WGCNA), immune infiltration analysis, single-cell sequencing analysis, machine learning, DEG analysis, and network pharmacology.ResultsThrough GO and KEGG analysis of weighted gene co-expression network analysis (WGCNA) modular genes and DEGs intersection, we found that the co-morbidity between T2DM and UC is primarily associated with immune-inflammatory pathways, including IL-17, TNF, chemokine, and toll-like receptor signaling pathways. Immune infiltration analysis supported these findings. Three distinct machine learning studies identified IGFBP3 as a biomarker for GQD in treating T2DM, while BACE2, EPHB4, and EPHA2 emerged as biomarkers for GQD in UC treatment. Network pharmacology revealed that GQD treatment for T2DM and UC mainly targets immune-inflammatory pathways like Toll-like receptor, IL-17, TNF, MAPK, and PI3K-Akt signaling pathways.ConclusionThis study provides insights into the shared pathogenesis of T2DM and UC and clarifies the regulatory mechanisms of GQD on these conditions. It also proposes novel targets and therapeutic strategies for individuals suffering from T2DM and UC.

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Section: Discussionmentioning

confidence: 99%

Deciphering the shared mechanisms of Gegen Qinlian Decoction in treating type 2 diabetes and ulcerative colitis via bioinformatics and machine learning

Hu,

Xiong,

et al. 2024

Front. Med.

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show abstract

“…Eph/ephrin proteins are implicated in numerous chronic inflammatory conditions. Targeting EPHB4 to disrupt EphB/ephrin B signaling holds potential as a pharmacological strategy for treating UC (50). In summary, the involvement of Eph/ephrin signaling in maintaining intestinal balance, managing inflammation, and regulating neuroimmune interactions offers exciting possibilities for future investigations and therapeutic advancements in gastrointestinal conditions (51).…”

Section: Single-cell Sequencing Analysismentioning

confidence: 99%

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Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer

Cited by 2 publications

References 61 publications

Deciphering the shared mechanisms of Gegen Qinlian Decoction in treating type 2 diabetes and ulcerative colitis via bioinformatics and machine learning

Deciphering the shared mechanisms of Gegen Qinlian Decoction in treating type 2 diabetes and ulcerative colitis via bioinformatics and machine learning

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