Ephedra mediated green synthesis of gold nanoparticles (AuNPs) and evaluation of its antioxidant, antipyretic, anti-asthmatic, and antimicrobial properties

Al‐Radadi, Najlaa S.

doi:10.1016/j.arabjc.2022.104353

Cited by 14 publications

(4 citation statements)

References 82 publications

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“…Ephedra is one of the oldest Chinese herbs, belonging to the Ephedra family, and is usually used to treat asthma, bronchitis, cough, etc It is also bacteriostatic and antipyretic. 28 A study validated the inhibitory effect of Ephedra on pro-inflammatory factors by molecular docking of 5 major human anti-inflammatory cytokine receptors ( IL-6 , hybrid TLR4 , TNF-α , IL-1β , and extracted TLR4 ). 21 Mori Cortex is an edible traditional Chinese medicine with antibacterial, anti-inflammatory, and treatment of asthma.…”

Section: Discussionmentioning

confidence: 99%

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Men,

Liu,

Yang

et al. 2024

Natural Product Communications

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Objective: To explore the efficacy and mechanism of action of Maqin Xiaoke Granules (MQs) in the treatment of acute bronchitis (AB). Methods: The rat model of AB was established by mixed smoke and Streptococcus pneumoniae nasal infection. The pathological changes of lung tissue and bronchus were observed by hematoxylin-eosin (HE) staining and scored. The mRNA expression levels of NOD-like receptor thermal protein domain associated protein 3 ( NLRP3) and p38 mitogen-activated protein kinase ( p38 MAPK) in lung tissue were detected by real-time fluorescence quantitative polymerase chain reaction, and the expression levels of inflammatory factors (tumor necrosis factor-α [ TNF-α], interleukin-6 [ IL-6], interleukin-1β [ IL-1β], interleukin-10 [ IL-10]) in serum and lung homogenate were detected by enzyme-linked immunosorbent assay. The therapeutic effect of MQ on rats with AB was preliminarily evaluated. Metabolic profiling of rat serum was performed by ultra high-performance liquid chromatography-quadrupole-time of flight-mass spectrometry/mass spectrometry, combining P < .05, variable important in projection > 1, fold change > 1.5 and screening for differential metabolites based on univariate and multivariate statistical analyses, and then analyzing the possible metabolic pathways with the help of MetaboAnalyst 5.0 database, to analyze the mechanism of MQ’s action on the treatment of AB at the metabolic level. Results: MQ significantly ameliorated the pathological injury of bronchial and lung tissues in model rats, reduced the mRNA levels of NLRP3 and p38 MAPK ( P < .05, .01), lowered the levels of TNF-α, IL-6, and IL-1β in serum and lung homogenates ( P < .05, .01), and elevated IL-10 in serum and lung homogenates ( P < .0001, .01) levels, and to regulate abnormal metabolites in rats with AB via the glycerophospholipid metabolic pathway. Conclusion: MQ significantly improved AB induced by mixed smoke combined with Streptococcus pneumoniae, and the mechanism of its induction may be related to the dysregulation of glycerophospholipid metabolism, and this study provides a reference for the rational clinical application of MQ.

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Section: Discussionmentioning

confidence: 99%

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Men,

Liu,

Yang

et al. 2024

Natural Product Communications

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“…AuNPs are small gold particles with diameters between 1 and 100 nm, also called colloidal gold when dispersed in water [61]. AuNPs are highly stable nanomaterials and have been extensively studied and applied [62].…”

Section: Aunpsmentioning

confidence: 99%

“…Size ranging between 1.3 and 15.6 nm with a spherical and triangle shape [61] Size ranging between 2.65 and 16.25 nm with a circular shape [67] Average size of 32.96 ± 5.25 nm with a spherical shape [99] Based on the research in Table 2, the AuNPs that are commonly produced using these synthesis methods are around 1-40 nm. There are several shapes produced from the synthesis of AuNPs, but the spherical shape is the most common form of AuNP produced.…”

Section: Physical Laser Ablationmentioning

confidence: 99%

Gold Nanoparticle-Based Colorimetric Sensors: Properties and Application in Detection of Heavy Metals and Biological Molecules

Kusuma,

Harmonis,

Pratiwi

et al. 2023

Sensors

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During the last decade, advances have been made in nanotechnology using nanomaterials, leading to improvements in their performance. Gold nanoparticles (AuNPs) have been widely used in the field of sensor analysis and are also combined with certain materials to obtain the desired characteristics. AuNPs are commonly used as colorimetric sensors in detection methods. In developing an ideal sensor, there are certain characteristics that must be met such as selectivity, sensitivity, accuracy, precision, and linearity, among others. Various methods for the synthesis of AuNPs and conjugation with other components have been carried out in order to obtain good characteristics for their application. AuNPs can be applied in the detection of both heavy metals and biological molecules. This review aimed at observing the role of AuNPs in its application. The synthesis of AuNPs for sensors will also be revealed, along with their characteristics suitable for this role. In the application method, the size and shape of the particles must be considered. AuNPs used in heavy metal detection have a particle size of around 15–50 nm; in the detection of biological molecules, the particle size of AuNPs used is 6–35 nm whereas in pharmaceutical compounds for cancer treatment and the detection of other drugs, the particle size used is 12–30 nm. The particle sizes did not correlate with the type of molecules regardless of whether it was a heavy metal, biological molecule, or pharmaceutical compound but depended on the properties of the molecule itself. In general, the best morphology for application in the detection process is a spherical shape to obtain good sensitivity and selectivity based on previous studies. Functionalization of AuNPs with conjugates/receptors can be carried out to increase the stability, sensitivity, selectivity, solubility, and plays a role in detecting biological compounds through conjugating AuNPs with biological molecules.

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“…Ephedra alata leaves contain various phytochemicals, including flavonoids, alkaloids and phenolic compounds. These leaves have been used as reducing and capping agents for the synthesis of gold, silver, and copper oxide NPs ( Mousavi et al, 2018 ; Al-Radadi, 2023 ; Antonio-Pérez et al, 2023 ; Atri et al, 2023 ; Bouzid et al, 2023 ). Therefore, Ephedra alata extracts could be used for NP production in order to address the concerns associated with the very high toxicity of conventional NP production systems that poses risks to human and animal health.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of a Ephedra alata leaf extract: Phytochemical analysis, antioxidant activity, antibacterial properties, and green synthesis of ZnO nanoparticles for photocatalytic degradation of methylene blue

Zaater,

Serhoud,

Ben Amor

et al. 2024

Front. Chem.

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Ephedra alata leaf extracts have therapeutic properties and contain various natural compounds known as phytochemicals. This study assessed the phytochemical content and antioxidant effects of a Ephedra alata leaf extract, as well as zinc oxide (ZnO) nanoparticle production. The extract contained phenolic acids, including vanillic acid, chlorogenic acid, gallic acid, p-coumaric acid, vanillin and rutin. Its total phenolic content and total flavonoid content were 48.7 ± 0.9 mg.g-1 and 1.7 ± 0.4 mg.g-1, respectively. The extract displayed a DPPH inhibition rate of 70.5%, total antioxidant activity of 49.5 ± 3.4 mg.g-1, and significant antimicrobial activity toward Gram-positive and negative bacteria. The synthesized ZnO nanoparticles had spherical shape, crystallite size of 25 nm, particle size between 5 and 30 nm, and bandgap energy of 3.3 eV. In specific conditions (90 min contact time, pH 7, and 25°C), these nanoparticles efficiently photodegraded 87% of methylene blue, suggesting potential applications for sustainable water treatment and pollution control.

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Ephedra mediated green synthesis of gold nanoparticles (AuNPs) and evaluation of its antioxidant, antipyretic, anti-asthmatic, and antimicrobial properties

Cited by 14 publications

References 82 publications

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Gold Nanoparticle-Based Colorimetric Sensors: Properties and Application in Detection of Heavy Metals and Biological Molecules

Exploring the potential of a Ephedra alata leaf extract: Phytochemical analysis, antioxidant activity, antibacterial properties, and green synthesis of ZnO nanoparticles for photocatalytic degradation of methylene blue

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