EphB2 SNPs and Sporadic Prostate Cancer Risk in African American Men

Robbins, Christiane M.; Hooker, Stanley; Kittles, Rick A.; Carpten, John D.

doi:10.1371/journal.pone.0019494

Cited by 25 publications

(21 citation statements)

References 21 publications

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“…For instance, the search of genes underlying the age-related macular degeneration undertaken with a small-scale GWAS using DNA samples from only 96 cases and 50 control subjects led to a prominent finding showing that a variant in complement factor H gene has an important causative effect (OR = 7.4) [46]. A case–control study of American African men on the association of EphB2 SNPs with PCa risk suggests that the power of GWAS study relies on high resolution haplotype maps based on African population [47]. Further analysis of our GWAS study should be performed when a high-resolution genetic maps of Arabs is available.…”

Section: Discussionmentioning

confidence: 99%

Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

et al. 2013

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BackgroundLarge databases focused on genetic susceptibility to prostate cancer have been accumulated from population studies of different ancestries, including Europeans and African-Americans. Arab populations, however, have been only rarely studied.MethodsUsing Affymetrix Genome-Wide Human SNP Array 6, we conducted a genome-wide association study (GWAS) in which 534,781 single nucleotide polymorphisms (SNPs) were genotyped in 221 Tunisians (90 prostate cancer patients and 131 age-matched healthy controls). TaqMan® SNP Genotyping Assays on 11 prostate cancer associated SNPs were performed in a distinct cohort of 337 individuals from Arab ancestry living in Qatar and Saudi Arabia (155 prostate cancer patients and 182 age-matched controls). In-silico expression quantitative trait locus (eQTL) analysis along with mRNA quantification of nearby genes was performed to identify loci potentially cis-regulated by the identified SNPs.ResultsThree chromosomal regions, encompassing 14 SNPs, are significantly associated with prostate cancer risk in the Tunisian population (P = 1 × 10-4 to P = 1 × 10-5). In addition to SNPs located on chromosome 17q21, previously found associated with prostate cancer in Western populations, two novel chromosomal regions are revealed on chromosome 9p24 and 22q13. eQTL analysis and mRNA quantification indicate that the prostate cancer associated SNPs of chromosome 17 could enhance the expression of STAT5B gene.ConclusionOur findings, identifying novel GWAS prostate cancer susceptibility loci, indicate that prostate cancer genetic risk factors could be ethnic specific.

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Section: Discussionmentioning

confidence: 99%

Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

et al. 2013

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“…PCa patients and controls ages 40 to 79 years old were recruited from six public and academic hospitals in Chicago, IL (Cook County Health and Hospital System, Northwestern Memorial Hospital, Jesse Brown Veterans Affairs Medical Center, University of Illinois Hospital and Health Science System, and University of Chicago Hospital) between 2009 and 2014 [18] and Washington, D.C. (Howard University Hospital) between 2000 and 2004 [19]. The patients underwent their first prostate biopsy due to an elevated or abnormal serum prostate specific antigen (PSA) level or an abnormal digital rectal examination.…”

Section: Methodsmentioning

confidence: 99%

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

et al. 2017

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BackgroundAfrican Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples.MethodsA total of 1,657 prostate cancer patients who underwent screening and healthy controls (888 African Americans, 620 European Americans, 111 Hispanic Americans, and 38 others) from Chicago, IL and Washington, D.C. were included in this study. Calcium and vitamin D intake were evaluated using food frequency questionnaire. We performed unconditional logistic regression analyses adjusting for relevant variables.ResultsIn the pooled data set, high calcium intake was significantly associated with higher odds for aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 1.98, 95% C.I.: 1.01–3.91), while high vitamin D intake was associated with lower odds of aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 0.38, 95% C.I.: 0.18–0.79). In African Americans, the association between high calcium intake and aggressive prostate cancer was statistically significant (ORQuartile 1 vs. Quartile 4 = 4.28, 95% C.I.: 1.70–10.80). We also observed a strong inverse association between total vitamin D intake and prostate cancer in African Americans (ORQuartile 1 vs. Quartile 4 = 0.06, 95% C.I.: 0.02–0.54). In European Americas, we did not observe any significant associations between either calcium or vitamin D intake and prostate cancer. In analyses stratifying participants based on Body Mass Index (BMI), we observed a strong positive association between calcium and aggressive prostate cancer and a strong inverse association between vitamin D intake and aggressive prostate cancer among men with low BMI (<27.8 kg/m2), but not among men with high BMI (≥27.8 kg/m2). Interactions of race and BMI with vitamin D intake were significant (P Interaction < 0.05).ConclusionCalcium intake was positively associated with aggressive prostate cancer, while vitamin D intake exhibited an inverse relationship. However, these associations varied by race/ethnicity and BMI. The findings from this study may help develop better prostate cancer prevention and management strategies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3060-8) contains supplementary material, which is available to authorized users.

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“…All participants provided written informed consent. The study and consent forms were approved by the Howard University Institutional Review Board [36, 37]. The present analysis is based on 248 men who provided demographic, lifestyle, dietary, and medical information.…”

Section: Methodsmentioning

confidence: 99%

Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis

et al. 2016

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Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer among African Americans. We examined the association between self-reported zinc intake and prostate cancer in a hospital-based case-control study of African Americans. We then compared our results with previous studies by performing a meta-analysis to summarize the evidence regarding the association between zinc and prostate cancer. Newly diagnosed African American men with histologically confirmed prostate cancer (n = 127) and controls (n = 81) were recruited from an urban academic urology clinic in Washington, DC. Controls had higher zinc intake, with a mean of 14 mg/day versus 11 mg/day for cases. We observed a non-significant, non-linear increase in prostate cancer when comparing tertiles of zinc intake (OR <6.5 vs 6.5–12.5mg/day 1.8, 95% CI: 0.6,5.6; OR <6.5 vs >12.5mg/day 1.3, 95% CI: 0.2,6.5). The pooled estimate from 17 studies (including 3 cohorts, 2 nested case-control, 11 case-control studies, and 1 randomized clinical trial, with a total of 111,199 participants and 11,689 cases of prostate cancer) was 1.07hi vs lo 95% CI: 0.98–1.16. Using a dose-response meta-analysis, we observed a non-linear trend in the relationship between zinc intake and prostate cancer (p for nonlinearity = 0.0022). This is the first study to examine the relationship between zinc intake in black men and risk of prostate cancer and systematically evaluate available epidemiologic evidence about the magnitude of the relationship between zinc intake and prostate cancer. Despite of the lower intake of zinc by prostate cancer patients, our meta-analysis indicated that there is no evidence for an association between zinc intake and prostate cancer.

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EphB2 SNPs and Sporadic Prostate Cancer Risk in African American Men

Cited by 25 publications

References 21 publications

Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis

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