Eph receptor–ephrin bidirectional signals that target Ras and Rho proteins

Mutational landscape of intrahepatic cholangiocarcinoma

“…4a). Although the role of ephrin-Eph interaction in cancer development is still obscure, it has been demonstrated that Eph receptors triggered by ephrins regulate Ras family proteins 46 and express highly in tumour cells 47 . Mutations in collagen, which is a component of extracellular matrix, are also enriched in ICC genomes (16%).…”

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

“…The signaling mechanisms responsible for EphA-dependent morphological effects in neurons and other cell types have not been fully elucidated, but it is becoming increasingly evident that small GTPases of the Rho and Ras families play a critical role (Noren and Pasquale, 2004). These GTPases regulate cell morphology primarily through reorganization of the actin cytoskeleton and by modulating cell adhesion.…”

A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases

“…In animal cells, transmembrane receptor tyrosine kinases (RTKs) constitute a large and diverse family of cell surface receptors that play important roles in fundamental cell processes [30]. A number of RhoGEFs (and, to a lesser extent, RhoGAPs) are activated by RTKs, leading to activation or inactivation of downstream Rho GTPases [31,32]. However, receptor tyrosine kinases appear to be absent in plants.…”