Eph/Ephrin-mediated Mesenchymal Stem Cell Regulation of T-cell Activation and Function

Nguyen, Thao M.; Arthur, Agnieszka; Gronthos, Stan

doi:10.4172/2155-9899.1000418

Cited by 2 publications

(1 citation statement)

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“…In those experimental conditions, the splenocyte numbers decreased with respect to those of cultures established without any Ad-MSCs only when they were cocultured with either WT or Eph-B2-LacZ Ad-MSCs but not in the presence of Eph-B2-or Eph-B3-deficient Ad-MSCs. These results confirm previous reports emphasizing that the blockade of Eph-B2 signaling in human MSCs reduces their immunosuppressive properties [39] and that Eph-B2 silencing in human MSCs reduces the production of IDO and iNOS, two immunosuppressive factors involved in MSC immunomodulation [74]. More importantly, we can conclude that Eph-B2 forward does not appear to play a relevant role in this process, but the reverse signaling mediated by ephrin-B must be involved, since Eph-B2-LacZ Ad-MSCs suppress the splenocyte proliferation.…”

Section: The Role Of Eph and Ephrins In The Immunomodulatory Propertisupporting

confidence: 92%

Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells

Alfaro

Rodriguez-Sosa

Zapata

2020

JCM

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Mesenchymal stromal/stem cells (MSCs) have emerged as important therapeutic agents, owing to their easy isolation and culture, and their remarkable immunomodulatory and anti-inflammatory properties. However, MSCs constitute a heterogeneous cell population which does not express specific cell markers and has important problems for in vivo homing, and factors regulating their survival, proliferation, and differentiation are largely unknown. Accordingly, in the present article, we review the current evidence on the relationships between Eph kinase receptors, their ephrin ligands, and MSCs. These molecules are involved in the adult homeostasis of numerous tissues, and we and other authors have demonstrated their expression in human and murine MSCs derived from both bone marrow and adipose tissue, as well as their involvement in the MSC biology. We extend these studies providing new results on the effects of Eph/ephrins in the differentiation and immunomodulatory properties of MSCs.

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Section: The Role Of Eph and Ephrins In The Immunomodulatory Propertisupporting

confidence: 92%