Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos

Krupke, Oliver A.; Zysk, Ivona; Mellott, Dan O; Burke, Robert D.

doi:10.7554/elife.16000

Cited by 11 publications

(3 citation statements)

References 56 publications

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“…The fact that a small proportion of EphA2Rs are trans-endocytosed in ephrin-A1-producing cells suggests that bidirectional signaling may take place at cytonemes. Interestingly, in sea urchin embryos, a transmembrane ephrin has been observed to localize to cytonemes at the basal surface of ectodermal cells (Krupke et al, 2016). In zebrafish, EB1-EphB3b signaling regulates cytonemal contacts between a hepatoblast and the adjacent lateral plate mesoderm, coordinating liver morphogenesis and laterality (Cayuso et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling

Valenzuela

Perez

2020

Developmental Cell

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Section: Discussionmentioning

confidence: 99%

Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling

Valenzuela

Perez

2020

Developmental Cell

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“…However, recent advances in microscopy revealed that both signal-producing and receiving cells could extend signaling filopodia named cytonemes and selectively deliver or receive signals through cytoneme-cell contact sites [4][5][6][7][8][9] . Essential roles of cytonemes or cytoneme-like filopodia have been discovered in many vertebrate and invertebrate systems and are implicated in most signaling pathways, including Hh, Dpp, FGF, EGF, Ephrin, and Wnt under various contexts [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . The prevalence and similarities of these signaling filopodia suggest that the polarized target-specific morphogen exchange through filopodial contacts is an evolutionarily conserved signaling mechanism.…”

Section: Introductionmentioning

confidence: 99%

GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion

Du¹,

Sohr²,

Li³

et al. 2021

Preprint

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During development, a handful of signals sculpt diverse tissue architectures. How the same signal produces different tissue/context-specific information and outcomes is poorly understood. We explored the basis that programs tissue-specific FGF dispersion and interpretation by cytoneme-mediated contact-dependent communication. Although a Drosophila FGF was thought to be freely secreted, we discovered that it is glypiated and GPI-anchored on the source cell surface, which inhibits non-specific secretion but facilitates tissue-specific cytoneme contact formation and contact-dependent release. For long-distance signaling, source and recipient cells extend FGF-containing and FGFR-containing cytonemes that contact and recognize each other by CAM-like receptor-ligand binding. FGF-FGFR binding reciprocally induces forward and reverse signaling in recipient and source cells, responses of which polarize their cytonemes toward each other to mutually self-sustain contacts. FGFR-bound FGF is then unanchored to hand-deliver FGF to receiving cytonemes, and cytoneme contacts dissociate. Thus, while cytonemes spatiotemporally control FGF dispersion/interpretation, FGF self-regulates its tissue-specific signaling by controlling cytonemes.

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“…Protein-protein interaction networks based on the top 50 and 10 EFNA4-binding proteins demonstrated a close relationship between EFNA4 and the EPHA and EPHB families, which was consistent with the results of a previous study (Figs. 8A-B) (22).…”

Section: Functional Enrichment Analysis and Gseamentioning

confidence: 99%

EFNA4 as a potential prognostic biomarker and therapeutic target for GBMLGG

Tang,

Zhang,

Liu

et al. 2024

Preprint

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Background Ephrin-A4 (EFNA4) is present in numerous tissues and is connected to the growth and development of multiple types of cancer. The differences in EFNA4 expression in various types of cancer and its impact on glioblastoma and low-grade glioma (GBMLGG) are not well understood. This research seeks to determine the prognostic value of EFNA4 in predicting the outcomes of GBMLGG and to examine the role of EFNA4 in tumorigenesis in GBMLGG. Methods The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to examine the differential expression and genetic alterations of EFNA4, and their relationship with patient survival in 33 cancer types. Multiple algorithms were used to examine the correlation between EFNA4 expression and the infiltration of cancer-associated fibroblasts, the immune infiltration landscape, expression of immunomodulatory genes, tumor mutational burden (TMB), and the microsatellite instability (MSI) score of GBMLGG. Univariate and multivariate Cox regression models and a nomogram were developed to forecast the outcomes of patients with GBMLGG. We also established protein-protein interaction networks, identified related functional signaling pathways, and conducted drug sensitivity analyses to examine the role of EFNA4 in the progression of GBMLGG. Results In most types of cancer, there was an increase in EFNA4 mRNA expression, which was found to be associated with prognosis. The expression of EFNA4 had a positive correlation with cancer-associated fibroblast infiltration levels in various cancer types, and the levels of EFNA4 expression were markedly elevated in tumor tissues in comparison to normal tissues in GBMLGG. Overexpression of EFNA4 was significantly correlated with tumor progression, a poor prognosis, and high immune scores in GBMLGG. The nomogram and EFNA4 expression status demonstrated their ability to accurately predict the outcomes of patients with GBMLGG. Moreover, it was discovered that the expression of EFNA4 had a considerable correlation with the expression of immunomodulatory genes and biological processes such as immune cell infiltration, the tyrosine kinase signaling pathway, neurotransmitter transmission between synapses, and epithelial-mesenchymal transition in GBMLGG. Conclusions The findings of this research indicate that EFNA4 has great potential as both a prognostic biomarker and a target for the therapy for GBMLGG.

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Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos

Cited by 11 publications

References 56 publications

Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling

Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling

GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion

EFNA4 as a potential prognostic biomarker and therapeutic target for GBMLGG

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