Abstract:Purpose:Bipolar patients have an increased risk of cardiovascular diseases for lifestyle habits and the use of antipsychotics that correlates with endothelial dysfunctions, in particular the decrease of eNOS activity and plasma NO levels. We aimed to examine the effects of the new atypical antipsychotic Asenapine on NO release and oxidative stress in porcine coronary endothelial cells (CEC).Methods:NO production was measured in CEC isolated from coronary arteries of pigs and plated in 0.1% gelatin-coated dishe… Show more
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