EP663 Correlation between adenomyosis and endometrial cancer: 6-year experience of a single center

Abstract

Introduction Adenomyosis often co-exists in the pathological specimens after surgery for endometrial cancer. The aim of this study is to describe the clinicopathological and oncological characteristics of these patients and further investigate the possibility of malignant transformation in the adenomyotic tissue. Methods We retrospectively reviewed the medical records of all patients that underwent hysterectomy for endometrial cancer (January 2012 – December 2017). The pathological reports were studied and when adenomyosis was present, the pathological slides were reviewed in order to discover any malignant change in the adenomyotic tissue. The clinicopathological characteristics and oncological results were described. Results Out of 229 cases of endometrial cancer, 64 (28%) patients had concurrently endometrial cancer and adenomyosis. Among these 64 patients, 7 (11%) had malignant transformation of adenomyosis. The mean age of patients suffering from both endometrial cancer and adenomyosis was 63.2 years old and 57 (89%) of these patients, had early endometrial cancer. Concerning the patients with malignant transformation of adenomyosis, their mean age was 65 years old with no premenopausal case. Discussion Adenomyosis has been described in the last decades, but its malignant transformation into endometrial cancer is not fully undercovered. Further investigation is needed in order to clarify the pathologic progression of adenomyotic lesions to endometrial cancer.

The Value of Adenomyosis Type in Clinical Assessment: A Single-center Experience of 755 Nodular and Diffuse Adenomyosis Cases

“…Among these 64 patients, 7 (11%) had a malignant transformation of adenomyosis. 30 In our study, endometrial carcinoma was found in 0.8% of patients with diffuse adenomyosis and all cases were early-stage, lowgrade hormone sensitive tumors. However, the number of our cases was relatively insufficient to make a general statement.…”

Prevalence of adenomyosis in endometrial cancer patients: a systematic review and meta-analysis

“…13 articles remained after abstracts screening, and were assessed for eligibility. Finally, eight studies were included in the qualitative and quantitative analyses [6][7][8][9][10][11][12][13] (Fig. 1).…”

“…Several studies have assessed the histological co-existence of endometrial carcinoma (EC) and adenomyosis reporting different data [6][7][8][9][10][11][12][13]. The two pathologies share common etiopathogenetic mechanisms including unopposed hyper-oestrogenic state, inflammatory milieu and molecular features favoring cell proliferation and inflammation [14][15][16][17][18][19][20].…”

Prognostic significance of co‐existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta‐analysis

“…In previous studies, adenomyosis coexisted with endometrial cancer in 0-70% 14 of cases, which is consistent with the studies we included 6.4-66% of cases. 4,[8][9][10][11][12][15][16][17][18][21][22][23][24] Furthermore, a population-based study comprising 768 patients with adenomyosis alone exhibited a fivefold increased risk of developing endometrial cancer. 25 Despite the common context, the mechanism of action of adenomyosis in endometrial cancer remains elusive.…”