EP289/#608 Timing of recurrence and overall survival in epithelial ovarian cancer: a 10-year retrospective review in a teaching hospital

Abstract

six series followed by six months of observation. After the observation, we determined the therapy's response with the RECIST Criteria (Response Criteria in Solid Tumors). Immunohistochemistry (retrospective) tests to ovarian cancer tissue and flow cytometry (prospective) blood tests then were performed to examine the expression of CD44 + /CD24 -, RAD6 and DDB2. Results There were significant overexpression of CD44 + / CD24 -, RAD6 and underexpression of DDB2 (p <0.05) in chemoresistance ovarian cancer tissue with significant AUC value (p<0.05). There were significant overexpression of CD44 + /CD24 -, and RAD6 (p <0.05) in blood circulation of chemoresistance ovarian cancer patients while CD44 + /CD24has significant AUC value (p<0.05) Conclusions We conclude that there were overexpression of CD44 + /CD24 -, RAD6, underexpression of DDB2 in ovarian cancer tissue, and overexpression of CD44 + /CD24in blood circulation and these proteins were good predictors of ovarian cancer chemoresistance.