EP06.20: Prenatal diagnosis of two cases of isolated periventricular nodular heterotopia (PNH) by ultrasound and MRI in the second trimester

Nieto, Olga; Recio, Manuel; Garicano, Ainhoa; Cañamares, Marina; Cruceyra, Mireia; Revello, Rocío; León, J. Rodriguez; Nuñez, V.; Jiménez, F. Marcos; Marin, Slobodan M.; Tamarit, I.

doi:10.1002/uog.21220

Cited by 2 publications

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“…However, cleft palate alone is difficult to detect on ultrasound imaging, and the diagnosis of cleft lip with or without cleft palate by ultrasound is not accurate enough in primary care settings [7]. Ultrasound detection results have certain limitations due to factors such as gestational age, amniotic fluid volume, and maternal obesity of pregnant women [11,12]. Consequently, if abnormalities are detected during this 2D ultrasound examination, it is recommended to refer pregnant women with affected fetuses to a tertiary center for a more comprehensive diagnosis [2].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Baeza-Pagador,

Tejero-Martínez,

Salom-Alonso

et al. 2024

JCM

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Background: Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imaging techniques for the prenatal diagnosis of cleft lip and palate, assess the pregnancy phase for orofacial clefts diagnosis, and study the different cleft types in terms of diagnostic methods, timing, and predictability. Methods: A search of the PubMed, EMBASE, Scopus, and Web of Science databases was conducted to identify potentially relevant studies published until January 2024. The quality of the selected articles was assessed using the Newcastle–Ottawa scale for methodological quality assessment of cohort studies and the QUADAS-2 scale for diagnostic test studies. Results: A total of 18 studies met the eligibility criteria and were included in the review. The findings of this review indicate that the majority of studies showed improved diagnostic accuracy when supplementary techniques, such as 3D ultrasound or magnetic resonance imaging, were added to 2D ultrasound. Conclusions: The implementation of magnetic resonance imaging as a standard procedure could significantly improve the precision of diagnosing cleft lip and palate. Therefore, the diagnostic technique used will play a crucial role in the accuracy of the diagnosis.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Baeza-Pagador,

Tejero-Martínez,

Salom-Alonso

et al. 2024

JCM

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“…However, its detection results have certain limitations due to factors such as gestational age, amniotic fluid volume, and maternal obesity of pregnant women. Several studies have pointed out that MRI has a positive role in prenatal diagnosis of fetal cleft lip and palate [ 7 , 8 ]. In addition, with the characteristics of multiple imaging, no ionizing radiation, and relatively objective diagnosis, MRI is less affected by the clinical experience of the operators, and its visual field is less affected by the fetal position.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value and Application of Prenatal MRI and Ultrasound in Fetal Cleft Lip and Palate

Yan

Xing

Wang

et al. 2022

Contrast Media & Molecular Imaging

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Objective. The purpose was to explore the diagnostic value and application of prenatal magnetic resonance imaging (MRI) and ultrasound (US) in fetal cleft lip and palate. Methods. From January 2018 to December 2019, 39 pregnant women without normal fetal maxillofacial structure or with fetal maxillofacial deformity under US examination in our hospital were selected as the study subjects. Not knowing the clinical data of the pregnant women, MRI and US physicians performed diagnostic analysis on the MRI or US images of all the study subjects and analyzed the results of prenatal MRI and US diagnosis and postpartum follow-up to compare the diagnostic efficacy and confidence of MRI and US. Results. The follow-up found that there were 20 cases of cleft lip, 15 cases of cheilopalatognathus, 3 cases of cleft palate, and 1 case of unilateral cleft lip with alveolar cleft, with a total of 39 cases having cleft lip and palate deformity. MRI and US had the same efficacy in the diagnosis of cleft lip. As for cleft palates, the diagnostic accuracy of MRI (94.87%) was significantly better than that of US (48.72%, P < 0.001). The diagnostic confidence of fetal cleft lip and palate by MRI (89.73%) was significantly better than that of US (43.59%, P < 0.001). The AUC of US (0.597) was significantly less than that of MRI (0.940), indicating that the diagnostic accuracy of US was not as good as that of MRI (P < 0.05). The sensitivity and 1 − specificity of MRI were significantly higher than those of US. Conclusion. MRI is more accurate than US in the diagnosis of fetal cleft lip and palate, and MRI can be the preferred method for prenatal detection of cleft lip and palate, thus providing more accurate opinions and information for perinatal pregnant women.

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EP06.20: Prenatal diagnosis of two cases of isolated periventricular nodular heterotopia (PNH) by ultrasound and MRI in the second trimester

Cited by 2 publications

References 0 publications

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Diagnostic Value and Application of Prenatal MRI and Ultrasound in Fetal Cleft Lip and Palate

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