EP-1187: T-lysyal based cream (Repalysyal) in the prevention of acute skin toxicity in breast cancer patients

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

“…Insufficient evidence was reported to support the use of any interventions for ARD prevention. 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 “n” indicates the number of studies. NS, not specified; RCT, randomized controlled trial; ARD, radiation dermatitis.…”

“…Alternative and multi-component therapies were assessed in 17 RCTs and 16 non-randomized studies 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 ( Appendix C, Table 7 ). Minimal difference was found between patients who used deodorant or antiperspirant and those who washed regularly, 167 , 168 did not use any intervention, 169 or used standard of care, 170 suggesting that antiperspirant/deodorant use should not be encouraged with the intent of preventing ARD.…”

“…Minimal difference was found between patients who used deodorant or antiperspirant and those who washed regularly, 167 , 168 did not use any intervention, 169 or used standard of care, 170 suggesting that antiperspirant/deodorant use should not be encouraged with the intent of preventing ARD. Similarly, most other interventions had no preventative benefit across RCTs, such as alkaline water, 172 or minimal benefit confined to one RCT, such as repalysyal 180 or other emulsions. 179 , 182 Based on evidence from multiple RCTs, aluminum/deodorant use and washing with water and soap do not worsen ARD, but there is insufficient evidence to support their use in the prevention of ARD.…”