Eotaxin/CCL11 Levels Correlate With Myocardial Fibrosis and Mast Cell Density in Native and Transplanted Rat Hearts

Zweifel, Martin; Matozan, Katja; Dahinden, Clemens A.; Schaffner, Thomas; Mohaçsi, Paul

doi:10.1016/j.transproceed.2010.05.152

Cited by 28 publications

(26 citation statements)

References 28 publications

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“…It is therefore likely that the migration of mast cells is under the control of several chemokines. Previous studies have demonstrated that a number of chemotactic factors such as CCL5, CCL11, CX3CL1, IL-8, IL-6 contributed to regulate the migration of human mast cells (Nilsson et al, 1999;Juremalm et al, 2002;El-Shazly et al, 2006;Hollins et al, 2008;Zweifel et al, 2010).In this study, we found that chemokines including CCL5, CCL11, CX3CL1, and IL-8 were up-regulated in the epithelial cells of nasal polyps, but IL-6 was not expressed by nasal epithelial cells. This indicated that these chemokines except for IL-6, released from epithelial cells of nasal polyps may be responsible for the migration of mast cells toward the epithelium in nasal polyps.…”

Section: Discussionsupporting

confidence: 49%

Distribution Change of Mast Cells in Human Nasal Polyps

Zhang

Shao

et al. 2012

The Anatomical Record

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Recent studies have shown that mast cells are involved in pathophysiologic processes of chronic inflammation. However, little is known about the distribution of mast cells in nasal polyps, which is a chronic inflammatory disease of the upper airways. Biopsy specimens from patients with nasal polyps (n ¼ 20) and control patients without nasal polyps (n ¼ 8) were included in this study. The distribution of mast cells in nasal polyps was determined by immunohistochemistry. Meanwhile, we detected the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8, IL-6) in the epithelial cells of normal nasal mucosa and nasal polyps. In addition, the expression of these chemokines was investigated by western bolting in airway epithelial cells line (A549 cells) under inflammatory condition. Mast cells migrated toward intraepithelium in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8) was up-regulated in the epithelial cells of nasal polyps compared with normal nasal mucosa. The expression of chemokines was also up-regulated in A549 cells after Lipopolysaccharide (LPS)-treatment for 3 hr and 6 hr. Our findings showed that mast cells migrate toward intraepithelium in nasal polyps and the overexpression of chemokines (CCL5, CCL11, CX3CL1, IL-8) suggested that they might be responsible for mast cells migration. It implies that mast cell play potential roles in the development of nasal polyps.

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Section: Discussionsupporting

confidence: 49%

Distribution Change of Mast Cells in Human Nasal Polyps

Zhang

Shao

et al. 2012

The Anatomical Record

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“…Among the cytokines upregulated by our HFD, eotaxin is the one demonstrated as a contributor to cardiac fibrosis [24]. Eotaxin is an important inflammatory chemokine in eosinophil chemotaxis.…”

Section: Discussionmentioning

confidence: 93%

“…Eotaxin expression levels increase with adipocyte differentiation [25], whereas its levels decrease in visceral adipose tissues when HFD-fed mice undergo weight loss [25]. In addition, eotaxin participates in cardiac fibrogenesis by triggering mast cell infiltration of the heart [24]. The O-MHO pigs exhibited a higher plasma level of eotaxin than C-MHO pigs, suggesting its potential role in the development of cardiac fibrosis.…”

Section: Discussionmentioning

confidence: 99%

The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

Liu

Chu

et al. 2017

Clinical Nutrition

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“…Some studies associate eotaxin to fibrosis in different tissues as heart, liver and lungs [29]–[31]. In JDM, eotaxin might induce similar tissue fibrosis, either by recruiting granulocytes that release pro-fibrotic substances, or by itself.…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 16.8 Years after Disease Onset; Associations with Disease Activity, Duration and Organ Damage

et al. 2014

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ObjectiveTo compare cytokine profiles in patients with juvenile dermatomyositis (JDM) after medium to long-term follow-up with matched controls, and to examine associations between cytokine levels and disease activity, disease duration and organ damage.MethodsFifty-four JDM patients were examined median 16.8 years (2–38) after disease onset (follow-up) and compared with 54 sex- and age-matched controls. Cytokine concentrations in serum were quantified by Luminex technology. In patients, disease activity score (DAS), myositis damage index (MDI) and other disease parameters were collected by chart review (early parameters) and clinical examination (follow-up).ResultsSerum levels of eotaxin, monocyte chemoattractant protein-1 (MCP-1) and interferon-inducible protein 10 (IP-10) were elevated in JDM patients compared to controls (31.5%, 37.2% and 43.2% respectively, all p<0.05). Patients with active (n = 28), but not inactive disease (n = 26) had a higher level of MCP-1 than their respective controls. Levels of eotaxin and MCP-1 correlated with disease duration (r = 0.47 and r = 0.64, both p<0.001) and age in patients, but not with age in controls. At follow-up, MDI was associated with MCP-1(standardized β = 0.43, p = 0.002) after adjusting for disease duration and gender. High MDI 1 year post-diagnosis predicted high levels of eotaxin and MCP-1 at follow-up (standardized β = 0.24 and 0.29, both p<0.05) after adjusting for disease duration and gender.ConclusionPatients with JDM had higher eotaxin, MCP-1 and IP-10 than controls. High eotaxin and MCP-1 at follow-up was predicted by early disease parameters, and MCP-1 was associated with organ damage at follow-up, highlighting a role of these chemokines in JDM.

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Eotaxin/CCL11 Levels Correlate With Myocardial Fibrosis and Mast Cell Density in Native and Transplanted Rat Hearts

Cited by 28 publications

References 28 publications

Distribution Change of Mast Cells in Human Nasal Polyps

Distribution Change of Mast Cells in Human Nasal Polyps

The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 16.8 Years after Disease Onset; Associations with Disease Activity, Duration and Organ Damage

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