“…Induced eosinophilia renders gerbils less susceptible to experimental amebic liver abscess (Vela squez et al 1995), and the very early stages of experimental amebic abscess of the liver reveal the presence ± albeit ephemeral ± of eosinophils in intimate contact with the parasite (Tsutsumi and MartinezPalomo 1988). Since eosinophils, like MPs, eventually also succumb in their confrontation with virulent amebas (Lo pez-Osuna et al 1992), one would have to look for eosinophil detritus (i.e., MBP, EPO, EDN, and ECP; Kretschmer and Lo pez-Osuna 1997) in the tissues to ascertain its real role in the pathogenesis of this extracellular protozoan infection, especially in cases where E. histolytica is portally injected into the liver but fails to develop an abscess.…”