Eosinophils and severe forms of graft-versus-host disease

Janin, Anne; Ertault-Daneshpouy, Marjan; Socié, Gérard

doi:10.1182/blood-2002-12-3650

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…10 In fact, it has been recently recognized that tissue eosinophilia may be a marker of acute inflammatory flares in GvHD. [11][12][13] These data strongly suggest that the presence of eosinophils is not a reliable indicator in the histologic differential diagnosis of GvHD.…”

Section: Discussionmentioning

confidence: 88%

Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease

Marra

McKee

Nghiem

2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 88%

Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease

Marra

McKee

Nghiem

2004

Journal of the American Academy of Dermatology

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“…Intriguingly, several studies have indicated eosinophilia as a favorable prognostic factor, associated with a less-severe course of aGVHD or cGVHD, as well as improved overall survival [5,6,[16][17][18][19]. Nevertheless, there is concern that eosinophil infiltration may be harmful to the organs of patients afflicted with GVHD [20].…”

Section: Introductionmentioning

confidence: 99%

Eosinophils in the blood of hematopoietic stem cell transplanted patients are activated and have different molecular marker profiles in acute and chronic graft‐versus‐host disease

Cromvik¹,

Johnsson

Vaht³

et al. 2014

Immunity, Inflammation and Disease

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While increased numbers of eosinophils may be detected in patients with graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation, it is not known if eosinophils play a role in GVHD. The aims of this study were to determine: whether eosinophils are activated during GVHD; whether the patterns of activation are similar in acute and chronic GVHD; and the ways in which systemic corticosteroids affect eosinophils. Transplanted patients (n = 35) were investigated for eosinophil numbers and the expression levels of 16 eosinophilic cell surface markers using flow cytometry; all the eosinophil data were analyzed by the multivariate method OPLS-DA. Different patterns of molecule expression were observed on the eosinophils from patients with acute, chronic, and no GVHD, respectively. The molecules that provided the best discrimination between acute and chronic GVHD were: the activation marker CD9; adhesion molecules CD11c and CD18; chemokine receptor CCR3; and prostaglandin receptor CRTH2. Patients with acute or chronic GVHD who received systemic corticosteroid treatment showed down-regulation of the cell surface markers on their eosinophils, whereas corticosteroid treatment had no effect on the eosinophil phenotype in the patients without GVHD. In summary, eosinophils are activated in GVHD, display different activation profiles in acute and chronic GVHD, and are highly responsive to systemic corticosteroids.

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“…Infiltration of eosinophils in the skin, gastrointestinal tract and liver in patients with aGvHD is often observed and may be harmful. [12][13][14]18 Basara et al 19 reported that an elevated concentration of eosinophils in BM was associated with grades 3-4 aGvHD after HSCT in their preliminary findings. On the other hand, there are some reports about an association between elevated concentration of eosinophils in PB and aGvHD; however, the association is still controversial, possibly due to the influence of corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 93%

“…[9][10][11] On the other hand, several studies evaluating histological findings of aGvHD, demonstrated infiltration of eosinophils in the involved organs, indicating an association between eosinophils and aGvHD. [12][13][14][15][16][17][18] Eosinophil infiltration in the target tissue after HSCT is acquired from donor cells, and their production in the bone marrow (BM) is stimulated by several physiologically active substances including interleukin-5, which are produced due to the allo-reactive immune response. Basara et al 19 reported the association between elevated eosinophils in BM and grades 3-4 aGvHD after HSCT, in their preliminary correspondence.…”

Section: Introductionmentioning

confidence: 99%

Elevated bone marrow eosinophil count is associated with high incidence of severe acute GvHD after allogeneic hematopoietic stem cell transplantation

Shimomura

Hara

Hashimoto

et al. 2017

Bone Marrow Transplant

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Predicting severe acute GvHD (aGvHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is challenging but critical. Mild aGvHD may have a favorable impact on relapse, whereas severe aGvHD is associated with poor outcomes. The aim of this study was to evaluate whether elevated eosinophil count in the bone marrow (BM) at 1 month after HSCT is associated with a high incidence of new and severe aGvHD. We enrolled 101 consecutive patients; median age was 50 years, and 50.5% patients were male. The median eosinophil concentration in BM at 1 month after HSCT was 1.1% (quartile 0.4-2.2%). The adjusted hazards ratio at 95% confidence interval for severe aGvHD was 1.26 (1.12-1.42, P<0.001), per 1% increase in eosinophil concentration, and 3.76 (1.41-10.05, P=0.008) for the high-risk group at a cutoff value of 4.0%. In addition, the predictive accuracy described by area under the curve of receiver operating characteristics, increased from 0.784 to 0.866 (P=0.033) with the increasing concentration of eosinophils. In conclusion, elevated concentration of eosinophils in BM was associated with high incidence and predictive accuracy of severe aGvHD. BM eosinophil concentration can be one of the key markers to predict aGvHD.

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Eosinophils and severe forms of graft-versus-host disease

Cited by 7 publications

References 5 publications

Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease

Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease

Eosinophils in the blood of hematopoietic stem cell transplanted patients are activated and have different molecular marker profiles in acute and chronic graft‐versus‐host disease

Elevated bone marrow eosinophil count is associated with high incidence of severe acute GvHD after allogeneic hematopoietic stem cell transplantation

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