Eosinophils

Rosenberg, Helene F.

doi:10.1016/b978-0-12-374279-7.03007-1

Cited by 5 publications

(11 citation statements)

References 107 publications

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“…1). MBPs, which are located in the core of large granules, have activities that affect smooth muscle contraction and peripheral nerve plasticity (Rothenberg and Hogan, 2006). ECP, EPO, and EDN are found in the cellular matrix of the large granules.…”

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

“…ECP is a ribonuclease A (RNase A) that has both cytotoxic and noncytotoxic activities. ECP has anti-viral activity and can also suppress the proliferation of T cells and immunoglobulin synthesis by B cells (Rothenberg and Hogan, 2006). EPO is more potent than myeloperoxidase (MPO), which is secreted by neutrophils to kill infectious organisms.…”

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

“…EPO, in contrast to MPO, forms a highly reactive oxygen species (hypobromous acid (HOBr)) in the presence of superoxide (Weiss et al, 1986). EDN, which is an RNase A and a cytotoxic agent, is associated with host defense against viruses and can be secreted by other inflammatory cells, such as mononuclear cells and neutrophils (Rothenberg and Hogan, 2006;Young and Meadows, 2010). Eosinophils are considered late-phase cells of the host immune response (Rothenberg and Hogan, 2006).…”

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

“…EDN, which is an RNase A and a cytotoxic agent, is associated with host defense against viruses and can be secreted by other inflammatory cells, such as mononuclear cells and neutrophils (Rothenberg and Hogan, 2006;Young and Meadows, 2010). Eosinophils are considered late-phase cells of the host immune response (Rothenberg and Hogan, 2006). They originate and develop from pluripotent stem cells in the bone marrow.…”

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

“…They originate and develop from pluripotent stem cells in the bone marrow. The regulation of eosinophil expansion is controlled by eosinophilopoietins, interleukin-1 (IL-1), IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) (Yang et al, 2001;Rothenberg and Hogan, 2006). Primitive stem cells become eosinophilic precursor myeloblasts in the presence of IL-1, IL-3, and GM-CSF (Yan and Shaffer, 2009).…”

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

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Canine eosinophilic gastrointestinal disorders

Sattasathuchana

Steiner

2014

Anim. Health. Res. Rev.

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Eosinophils play a crucial role in the inflammatory response in conjunction with both innate and adaptive immunity. Eosinophils have long been recognized as inflammatory leukocytes that are particularly important in patients with parasitic infestations. However, recent studies in veterinary medicine demonstrate a number of canine eosinophilic gastrointestinal (GI) disorders unrelated to a parasitic infestation. Although the underlying pathophysiology behind eosinophilic infiltration of the canine GI tract remains uncertain, medical intervention aiming to decrease the activation of eosinophils seems effective in reducing symptoms and preventing organ damage. This review focuses on the biology of eosinophils and their products. It describes, the composition of eosinophil granules, mechanisms of eosinophil activation, and eosinophil-related disease processes leading to organ damage. Even though the main clinical signs of canine eosinophilic gastroenteritis, vomiting and diarrhea, are similar to those of other types of gastroenteritis, the clinical response and prognosis are worse for this condition. The clinical signs and diagnostic approach for eosinophilic GI disorders are described and compared between canine and human patients for each region of GI tract, from the esophagus to the colon. Moreover, the current treatments for this syndrome in canine and human patients are summarized and paralleled. The comparative study of canine and human patients with eosinophilic gastroenteritis will advance the understanding of this syndrome in both species and may lead to the development of novel treatment strategies.

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Section: Morphology Of Eosinophilsmentioning

confidence: 99%

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

Section: Morphology Of Eosinophilsmentioning

confidence: 99%

See 3 more Smart Citations

Canine eosinophilic gastrointestinal disorders

Sattasathuchana

Steiner

2014

Anim. Health. Res. Rev.

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A Next-Generation Bacteria (Akkermansia muciniphila BAA-835) Presents Probiotic Potential Against Ovalbumin-Induced Food Allergy in Mice

Miranda

Souza

Quintanilha

et al. 2023

Probiotics & Antimicro. Prot.

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Diagnosis and treatment of eosinophilia

Batta¹

2020

Magna Sci. Adv. Biol. Pharm.

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Eosinophilia is frequently seen being the basis of various pathologies in the body. Eosinophilia is a condition when the blood count is raised to more than 500 per microliter; however it can vary from mild to severe. Idiopathic hypereosinophilic syndrome has been found to be a cause of moderate to severe eosinophilia. Improvement in treatment depends on the cause of the rise in count. This review will make the approach to diagnose the cause and treatment accordingly.

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Eosinophils

Cited by 5 publications

References 107 publications

Canine eosinophilic gastrointestinal disorders

Canine eosinophilic gastrointestinal disorders

A Next-Generation Bacteria (Akkermansia muciniphila BAA-835) Presents Probiotic Potential Against Ovalbumin-Induced Food Allergy in Mice

Diagnosis and treatment of eosinophilia

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