Eosinophilic Spongiosis in Pemphigus

Emmerson, R.W.; Wilson‐Jones, E.

doi:10.1001/archderm.1968.01610090024004

Cited by 92 publications

(20 citation statements)

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“…Although occasional cleft formation and acantholysis were seen in the suprabasal layer, eosinophilic spongiosis was present, which is known as a characteristic feature of HP. However, eosinophilic spongiosis can be also observed in classic forms of pemphigus and bullous pemphigoid (8) and is not considered specific for HP (9). Based on the characteristic clinical features, we favored the diagnosis of HP for this case.…”

Section: Discussionmentioning

confidence: 99%

A Case of Herpetiform Pemphigus with Anti‐Desmoglein 3 IgG Autoantibodies

Isogai

Kawada

Aragane

et al. 2004

The Journal of Dermatology

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Herpetiform pemphigus (HP) is a rare variant of pemphigus characterized by a unique clinical phenotype of erythematous or urticarial plaques and vesicles that present in a herpetiform arrangement. Most HP cases have circulating anti-desmoglein 1 (Dsg1) IgG autoantibodies, but some HP cases have anti-desmoglein 3 (Dsg3) IgG. A 92-year-old Japanese woman presented with severely pruritic annular erythema and vesicles in a herpetiform arrangement on the trunk. No oral mucosal lesions were present. Histopathologically, these vesicles showed eosinophilic spongiosis as well as suprabasilar acantholysis. Direct immunofluorescence showed in vivo IgG deposition on keratinocyte cell surfaces, and indirect immunofluorescence showed circulating IgG autoantibodies against keratinocyte cell surfaces at a titer of 1:30. Enzyme-linked immunosorbent assay using recombinant Dsg1 and Dsg3 revealed the presence of anti-Dsg3 IgG but no anti-Dsg1 IgG autoantibodies. The lack of oral mucosal involvement and the unique clinical features favored the diagnosis of HP. It remains to be clarified why the anti-Dsg3 IgG autoantibodies in this patient induced this unique features of HP, rather than the mucosal dominant type of pemphigus vulgaris.

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Section: Discussionmentioning

confidence: 99%

A Case of Herpetiform Pemphigus with Anti‐Desmoglein 3 IgG Autoantibodies

Isogai

Kawada

Aragane

et al. 2004

The Journal of Dermatology

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“…5-7 Other cases were later described, which showed circulating and in vivo bound pemphigus antibodies. 8-10 In 1975, Jablonska et al 11 described a similar case and proposed the name pemphigus herpetiformis (PH).…”

Section: Pemphigus Herpetiformismentioning

confidence: 99%

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus

Porro

Caetano

Maehara

et al. 2014

An. Bras. Dermatol.

122

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The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. These are reviewed in this article. Future research may help definitively to locate the position of these forms in the pemphigus group, especially with regard to pemphigus herpetiformis and the IgG/ IgA pemphigus.

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“…The use of dapsone in the treatment of pemphigus vulgaris is mostly reported in those cases described as dermatitis herpetiformis associated with pemphigus [6,[17][18][19], The use of this agent as a substitute for corticosteroids in unquestionable cases with this malady has, to the best of our knowledge, been reported on one occasion only [4].…”

Section: Discussionmentioning

confidence: 99%