Eosinophilic pustular folliculitis successfully treated with sequential therapy of interferon-γ and ciclosporin

Sugita, Kazunari; Kabashima, Kenji; Koga, Chizuko; Tokura, Y.

doi:10.1111/j.1365-2230.2006.02169.x

Cited by 13 publications

(15 citation statements)

References 6 publications

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“…Our results showed that classic EPF was successfully treated mainly by systemic indomethacin, whereas other types mainly by topical steroids. Other regimens such as topical tacrolimus, oral Sairei‐to , oral cyclosporin, systemic IFN‐α‐2b, IFN‐γ and anti‐TNF‐α were also used with success …”

Section: Discussionsupporting

confidence: 60%

Eosinophilic pustular folliculitis: A published work‐based comprehensive analysis of therapeutic responsiveness

Nomura

Katoh

Yamamoto

et al. 2016

The Journal of Dermatology

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Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that were described in articles published between 1965 and 2013. In total, there were 1171 regimens; 874, 137, 45 and 115 of which were applied to classic, IS/HIV, IS/non-HIV and infancy-associated EPF, respectively. Classic EPF was preferentially treated with oral indomethacin with efficacy of 84% whereas topical steroids were preferred for IS/HIV, IS/non-HIV and infancy-associated EPF with efficacy of 47%, 73% and 82%, respectively. Other regimens such as oral Sairei-to (a Chinese-Japanese herbal medicine), diaminodiphenyl sulfone, cyclosporin and topical tacrolimus were effective for indomethacin-resistant cases. Although the preclusion of direct comparison among cases was one limitation, this study provides a dataset that is applicable to the construction of therapeutic algorithms for EPF.

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Section: Discussionsupporting

confidence: 60%

Eosinophilic pustular folliculitis: A published work‐based comprehensive analysis of therapeutic responsiveness

Nomura

Katoh

Yamamoto

et al. 2016

The Journal of Dermatology

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“…The results suggest that indomethacin was not effective in 7.7% of patients, highlighting the need for other treatment options for EPF. In previous studies, there have been reported cases of EPF successfully treated with other drugs, including oral cyclosporine, oral antibiotics and topical steroids [8,20,21,22,23]. Table 3 shows the effectiveness of drugs other than oral indomethacin in the present study, and the results suggest that most doctors were less likely to try oral antibiotics and topical steroids in the treatment of EPF.…”

Section: Discussionsupporting

confidence: 45%

Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan

Yamamoto

Nomura²,

Kabashima³

2014

Dermatology

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Background: No epidemiological study has examined the clinical characteristics, including medication use, of patients with eosinophilic pustular folliculitis (EPF). Objective: To describe the clinical characteristics for EPF and to examine the factors associated with the effectiveness of oral indomethacin for EPF. Methods: A cross-sectional study was performed of patients with EPF who visited the dermatology departments of the 67 main teaching facilities in Japan. We documented the patient characteristics and examined factors associated with the effectiveness of oral indomethacin. Results: A total of 145 patients with EPF were enrolled; 62.8% were prescribed oral indomethacin. A multivariable analysis revealed that female patients were more likely to exhibit complete response to oral indomethacin after adjustment for confounders (adjusted proportion ratio = 1.93, p = 0.04). Conclusion: Oral indomethacin has been accepted as a first-line treatment in EPF. Our results suggest that there is a sex difference in the treatment response to oral indomethacin.

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“…The most common form of treatment was oral indomethacin, a non‐steroidal anti‐inflammatory drug (NSAID). Other forms include acemetacin, minocycline, indomethacin in combination with minocycline, dimethyl diphenyl sulfone, oral steroids, topical steroids, cyclosporin, γ‐interferon and topical tacrolimus (Table ) . Oral indomethacin was effective in 75% of cases in which it was tried.…”

Section: Resultsmentioning

confidence: 99%

Eosinophilic pustular folliculitis: A review of the Japanese published works

Katoh

Nomura

Miyachi

et al. 2012

The Journal of Dermatology

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Eosinophilic pustular folliculitis (EPF), also known as Ofuji's disease, is an inflammatory dermatosis that was first described in Japan in 1970. More than 300 cases have been reported so far, and 113 Japanese cases have been reported in Japan since 1980. To comprehend the characteristics of Japanese EPF cases, we classified these cases into three types: classic, immunosuppression-associated (IS-EPF), and infancy-associated (I-EPF). Trends in age of onset and in distribution and characterization of eruptions differed between the types. We found 91 cases of classic EPF (mean age, 39.7 years), consisting of 66 males (73%) and 25 females (27%), in most of which eruptions primarily affected the face; 18 cases of IS-EPF (44.2 years), consisting of 15 males (83%) and three females (17%), in which eruptions affected the face less predominantly; and four cases of I-EPF (7.0 years), consisting of two males (50%) and two females (50%), primarily affecting the scalp. The number of IS-EPF cases has increased since the late 1990s, reflecting the increasing number of HIV-positive patients in Japan. Systemic nonsteroidal anti-inflammatory drugs were effective in more than 70% of cases. Dimethyl diphenyl sulfone, antibiotics including minocycline, psoralen plus ultraviolet A therapy and ultraviolet B treatments worked in some cases. Topical steroids and tacrolimus were also effective in some cases of EPF, while topical indomethacin was less effective.

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Eosinophilic pustular folliculitis successfully treated with sequential therapy of interferon-γ and ciclosporin

Cited by 13 publications

References 6 publications

Eosinophilic pustular folliculitis: A published work‐based comprehensive analysis of therapeutic responsiveness

Eosinophilic pustular folliculitis: A published work‐based comprehensive analysis of therapeutic responsiveness

Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan

Eosinophilic pustular folliculitis: A review of the Japanese published works

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