Eosinophilic Pleural Effusion Induced by Paliperidone Palmitate: Case Report and Literature Review

Ghellinck, Léopold de; Frusch, Nicolas; Duysinx, Bernard

doi:10.1016/j.jaclp.2022.02.010

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…infections, Dracunculus medinensis infection, sparganosis, toxocariasis, cutaneous myasis, loiasis, strongyloidiasis, echinococcosis, lymphatic filariasis, ascariasis, amebiasis), autoimmune disorders (rheumatoid arthritis, Churg-Straus disease, sarcoidosis, systemic lupus erythematosus, eosinophilic fasciitis) and it can even be idiopathic [ 4 – 7 ]. Eosinophilia, which is defined as the elevation of the eosinophil count in the peripheral blood above 0.5×10 3 /μL [ 8 ], can be associated with EPE and usually disappears after the pleural effusion resolves [ 5 ]. The peripheral blood eosinophil percentage is usually less than the pleural eosinophil percentage [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Pleural Effusion Secondary to Trichinella spiralis Infection in a Patient with Systemic Sclerosis: A Case Report

Vulcan,

Dragne,

Badea

2024

Am J Case Rep

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Patient: Male, 49-year-old Final Diagnosis: Systemic sclerosis Symptoms: Arthralgia • fatigue • night sweats • paresthesia • posterior thoracic pain Clinical Procedure: — Specialty: General and Internal Medicine • Rheumatology Objective: Rare coexistence of disease or pathology Background: Scleroderma is a chronic autoimmune disease characterized by angiopathy, autoimmunity, and fibrosis. One form of scleroderma, systemic sclerosis, is characterized by diffuse skin lesions and visceral involvement. Eosinophilic pleural effusion is a rare complication attributed to a large array of diseases. We present a case of a man with underlying systemic sclerosis who developed eosinophilic pleural effusion as a complication of associated Trichinella spiralis infection. Case Report: A 49-year-old man presented for bilateral inflammatory radio-ulnar-carpal joint pain, paresthesia of the hands and forearms and a 2-week history of right posterior aching thoracic pain and night sweats. The physical examination revealed sclerodermatous skin involvement of the hands, forearms, and forehead, sclerodactyly, Raynaud’s phenomenon, and telangiectasias, together with muffled cardiac sounds and right basal abolishment of the vesicular breath sounds. Imagistic evaluation showed the presence of pleuro-pericardial fluid. A thoracocentesis highlighted the presence of an exudative eosinophilic pleural effusion. Laboratory findings showed leukocytosis, with elevated neutrophil and eosinophil counts. The patient was tested for a parasitic infection, but initially the results were negative. He started anti-inflammatory treatment, but no reduction of the pleural fluid was observed. Subsequent evaluation revealed specific anti-trichinella IgG antibodies. Albendazole and corticosteroid therapy were initiated, which resulted in remission of the symptoms. Conclusions: This report highlights the possibility of developing rare or even not-until-now seen complications when 2 etiologically different diseases are associated. The physician should carefully assess the situation to find and resolve the underlying causes.

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