Eosinophilic Oesophagitis in Infants and Children in the Region of Southern Denmark: A Prospective Study of Prevalence and Clinical Presentation

Dalby, Kasper; Nielsen, Rasmus Gaardskær; Kruse-Andersen, S; Fenger, Claus; Bindslev‐Jensen, Carsten; Ljungberg, Susanne; Larsen, Kirsten Toksvig; Walsted, Anne-Mette; Husby, Steffen

doi:10.1097/mpg.0b013e3181d1b107

Cited by 61 publications

(63 citation statements)

References 13 publications

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“…The majority of the patients being white, which reflects the patient population in the area, is in concordance with the current literature showing that EoE disproportionally affects non-Hispanic white subjects. 1,7,11 In accordance with the literature, our findings illustrate a high prevalence of comorbid atopic diseases and sensitizations to food and environmental allergens in both children and adults. However, we found that children had a significantly higher rate of asthma and positive patch test to foods compared with adults.…”

Section: Discussionsupporting

confidence: 78%

“…6,7,10 EoE occurs in most racial and ethnic groups, but through observational studies EoE appears to disproportionally affect non-Hispanic white subjects with an increased male-to-female ratio. 1,7,11 Patients with EoE often have a concurrent or history of atopic diseases as well as a family history of atopy. Atopic diseases such as food allergy, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and asthma have been reported in the majority of patients with EoE (50 -80%).…”

mentioning

confidence: 99%

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Comparison of atopic features between children and adults with eosinophilic esophagitis

Vernon

Shah²,

Lehman³

et al. 2014

allergy asthma proc

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Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

Comparison of atopic features between children and adults with eosinophilic esophagitis

Vernon

Shah²,

Lehman³

et al. 2014

allergy asthma proc

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“…The inflammatory response may cause bleeding, with blood in the vomit. Gastro-oesophageal reflux disease can occur as an adverse reaction to food, particularly in children, with or without development of eosinophilic oesophagitis (Moon and Kleinman, 1995;Ireland-Jenkin et al, 2008;Dalby et al, 2010).…”

Section: Vomiting and Gastro-oesophageal Reflux Diseasementioning

confidence: 99%

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Products¹

2014

EFS2

115

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Following a request from the Food Safety Authority of Ireland, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) was asked to deliver a scientific opinion on the evaluation of allergenic foods and food ingredients for labelling purposes. In view of the request, the NDA Panel decided to update its previous opinions relative to food ingredients or substances with known allergenic potential listed in Annex IIIa of 2003/89/EC, as amended. These include cereals containing gluten, milk and dairy products, eggs, nuts, peanuts, soy, fish, crustaceans, molluscs, celery, lupin, sesame, mustard and sulphites. The opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. It includes information on the prevalence of food allergy in unselected populations, proteins identified as food allergens, cross-reactivities, the effects of food processing on the allergenicity of foods and ingredients, methods for the detection of allergens and allergenic foods, doses observed to trigger adverse reactions in sensitive individuals and risk assessment methodologies that have been used to derive individual and population thresholds for selected allergenic foods. The present opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. For each food ingredient or substance listed in Annex IIIa, it includes information on the prevalence of food allergy in unselected populations, on proteins identified as food allergens, on cross-reactivities, on the effects of food processing on the allergenicity of foods and ingredients, on methods for the detection of allergens and allergenic foods, and on doses observed to trigger adverse reactions in sensitive individuals.Immune-mediated adverse reactions to foods manifest with clinical signs and symptoms of variable severity and duration, which may affect different organs and systems. Anaphylactic reactions to food are IgE mediated and may occur at any age. Non-IgE-mediated food allergy includes a wide range of diseases, including protein-induced enterocolitis and eosinophilic oesophagitis.A careful family and clinical history are the basis for diagnosis of food allergy. Food diaries, skin prick tests (SPTs), allergen-specific IgE measurements, food elimination diets and food challenges are part of the standard protocol for the diagnosis of food allergy. A positive SPT indicates sensitisation to the tested food, but it is not diagnostic of food allergy. Allergen-specific serum IgE antibodies similarly denote sensitisation to a particular food, but they are not diagnostic without a clinical history or food challenge. The use of atopy patch tests for the diagnosis of food allergy is controversial. Other available tests have no current role in the diagnosis of food allergy. Diag...

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“…Other studies on retrospective review of upper endoscopy procedure or histopathology reports of children also describe increasing prevalence rates during the last years [11,12,13,14]. In a prospective evaluation of children and infants in Southern Denmark (pediatric population of 256,164; age: 0-16 years) with symptoms of gastroesophageal reflux disease during an 18-month period, 6 patients were diagnosed with EoE, corresponding to an annual incidence rate of 1.6 per 100,000 children [15]. A recent review summarizing 25 epidemiological studies concerning incidence and prevalence of EoE in children showed that the incidence of EoE varied depending on the geographic location from 0.7 to 10/100,000 per person-year and the prevalence ranged from 0.2 to 43/100,000 children and increased over time.…”

Section: Incidence and Prevalence Of Eoe Based On Endoscopy And Histomentioning

confidence: 99%

Epidemiology of Eosinophilic Esophagitis

Hrúz¹

2014

Dig Dis

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Eosinophilic esophagitis (EoE) is an allergy-associated disease defined clinically by esophagus-related symptoms in combination with a dense esophageal eosinophilia, both of which are unresponsive to prolonged acid suppression with proton pump inhibitors. Over the last two decades EoE has increasingly been recognized in various geographical areas (mostly industrialized countries) with high socioeconomic development. The prevalence rate is increasing and reaches up to 50 patients per 100,000 inhabitants in some indicator regions. Whether this increased prevalence is due to a real increase in incidence, a result of increased awareness by health care providers or because of the nonfatal nature of EoE adding more and more cases to the patient pool is still a matter of controversy. Several studies have consistently demonstrated a male predominance in EoE, with a male-to-female risk ratio of 3:1. The average age at diagnosis ranges between 30 and 50 years and suggests that EoE is a disease of the middle-aged man. It can affect patients of every race, but the disease is more common among Caucasians. In both children and adults, EoE has been clearly associated with allergies to food and aeroallergens, and most EoE patients present with a personal allergic background (e.g. asthma, rhinoconjunctivitis or oral allergy syndrome). In conclusion, knowledge of epidemiologic parameters of EoE is crucial for identifying risk factors as well as pathogenic mechanisms, planning preventive measures and determining optimal treatment strategies.

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Eosinophilic Oesophagitis in Infants and Children in the Region of Southern Denmark: A Prospective Study of Prevalence and Clinical Presentation

Abstract: We report a European prospective study of EE. It was documented in 6 of 78 patients with symptoms of GERD corresponding to an annual incidence of 0.16/10,000 infants and children.

Cited by 61 publications

References 13 publications

Comparison of atopic features between children and adults with eosinophilic esophagitis

Comparison of atopic features between children and adults with eosinophilic esophagitis

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Epidemiology of Eosinophilic Esophagitis

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