Eosinophilic Lymphoid Granuloma (Kimura’s Disease)

Kimura's Disease

“…DISCUSSION Kimura's disease is a rare, benign disease, histologically characterized by numerous eosinophils and, more typically, proliferation of lymphod follicles in the lower dermis and subcutaneous tissue. In Japan, over 400 cases have been reported to date, with males more often affected than females (9)(10)(11)(12)(13). The age of onset is usually in the teens, but ranges from below 10 years of age to over 60.…”

“…The age of onset is usually in the teens, but ranges from below 10 years of age to over 60. The lesions are manifested as solitary or multiple nodular subcutaneous tumors, and generally involve the head and neck, supraclavicular, axillar and inguinal regions, especially the cheek (46 %) (9)(10)(11)(12)(13).…”

“…They are usually slowly progressive in growth. The total peripheral eosinophil count is elevated in many cases, usually 30-40% of all white blood cells, usually amounting to more than 10,000 per cmm (9)(10)(11)(12)(13)(14). The serum IgE level is over 1,000 units per ml, and positive intradermal tests with candida are reported in many cases (9)(10)(11)(12)(13)(14).…”

“…The total peripheral eosinophil count is elevated in many cases, usually 30-40% of all white blood cells, usually amounting to more than 10,000 per cmm (9)(10)(11)(12)(13)(14). The serum IgE level is over 1,000 units per ml, and positive intradermal tests with candida are reported in many cases (9)(10)(11)(12)(13)(14). For treatment of this disease, a combination of surgical excision, drug administration of steroids and irradiation is routinely carried out in Japan (9)(10)(11)(12)(13)(14)(15).…”

“…The serum IgE level is over 1,000 units per ml, and positive intradermal tests with candida are reported in many cases (9)(10)(11)(12)(13)(14). For treatment of this disease, a combination of surgical excision, drug administration of steroids and irradiation is routinely carried out in Japan (9)(10)(11)(12)(13)(14)(15).…”