Eosinophilic lymph node abscesses following a COVID-19 vaccination: A case report

Kaya, Abdurrahman; Kaya, Sibel Yıldız; Abul, Azat; Fener, Neslihan; Can, Ali; Mert, Ali

doi:10.1016/j.jnma.2023.01.003

Cited by 3 publications

(7 citation statements)

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“…A case of atypical follicular hyperplasia with light chain‐restricted germinal centres after a COVID‐19 booster was described, 62 but the specific vaccine was not reported. A case of C19‐LAP with eosinophilic abscesses has also been reported 43 . The histological features showed eosinophil‐rich inflammation with micro‐abscesses 43 .…”

Section: Methodsmentioning

confidence: 99%

“…No restrictions were placed on the year of publication. Only literature published in English was selected, including studies that reported histopathological and/or cytological findings in vaccine‐related lymphadenopathy 17,20,22,23,35–64 . Studies on SLDI, which was generally detected by 18F‐FDG PET‐CT, were also selected and used for the general comprehension and description of the phenomenon and to retrieve cases evaluated by histology or LN‐FNAC 65–68 .…”

Section: Methodsmentioning

confidence: 99%

“…While most cases of SLDI do not show clinically evident enlargement of lymph nodes, an awareness of SLDI among doctors is of fundamental importance in a variety of clinical contexts, particularly with regard to cancer staging and follow‐up to avoid the risk of overdiagnosis. In our research, surgical excision or CNB of C19‐LAP‐ or SLDI‐enlarged lymph nodes have been performed in 55 cases 20,22,23,35,39,41–43,47,49–63 . The histological diagnoses were as follows: negative for neoplasia, reactive hyperplasia, and florid reactive hyperplasia (39 cases), 23,39,50–61 progressive transformation of germinal centres (1 case), 54 atypical follicular hyperplasia with light chain‐restricted germinal centres (1 case) 62 granulomatous reaction (2 cases), 50,63 metastases (4 cases), 20,22,50 Kikuchi‐Fujimoto disease (KFD; 6 cases), 40–42,49,56,64 Rosai‐Dorfman‐Destombes disease (RDD; 1 case), 48 and Langerhans cell histiocytosis (LCH; 1 case) 57 .…”

Section: Methodsmentioning

confidence: 99%

“…In our research, surgical excision or CNB of C19-LAP-or SLDI-enlarged lymph nodes have been performed in 55 cases. 20,22,23,35,39,[41][42][43]47,[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] The histological diagnoses were as follows: negative for neoplasia, reactive hyperplasia, and florid reactive hyperplasia (39 cases), 23,39,[50][51][52][53][54][55][56][57][58][59][60][61] progressive transformation of germinal centres (1 case), 54 atypical follicular hyperplasia with light chain-restricted germinal centres (1 case) 62 granulomatous reaction (2 cases), 50,63 metastases (4 cases), 20,22,50 Kikuchi-Fujimoto disease (KFD; 6 cases), [40][41]…”

Section: Covid-19 Vaccines and Lymphadenopathymentioning

confidence: 99%

“…Lymph node excision and core-needle biopsy (CNB) were the most frequently performed procedures for the pathological evaluation of COVID-19 post-vaccine lymphadenopathy. We retrieved 48 cases of C19-LAP with histological control (excision or CNB ) 22,23,39,43,48,49,51,53,56,57,61,62 and diagnosed as negative or reactive with or without follicular hyperplasia (37 cases). Two cases were reported as florid lymphoid hyperplasia 54,57 ; KFD was reported in four cases 37,39,49,56 (16.7%).…”

Section: Pathology Of Covid-19 Post-vaccine Lymphadenopathymentioning

confidence: 99%

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COVID‐19 post‐vaccination lymphadenopathy: A review of the use of fine needle aspiration cytology

et al. 2023

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COVID‐19 vaccine‐associated clinical lymphadenopathy (C19‐LAP) and subclinical lymphadenopathy (SLDI), which are mainly detected by 18F‐FDG PET‐CT, have been observed after the introduction of RNA‐based vaccines during the pandemic. Lymph node (LN) fine needle aspiration cytology (FNAC) has been used to diagnose single cases or small series of SLDI and C19‐LAP. In this review, clinical and LN‐FNAC features of SLDI and C19‐LAP are reported and compared to non‐Covid (NC)‐LAP. A search for studies on C19‐LAP and SLDI histopathology and cytopathology was performed on PubMed and Google Scholar, on 11 January 2023. Reports on LN‐FNAC of C19‐LAP were retrieved. A total of 14 reports, plus one unpublished case of C19‐LAP observed in our institution, diagnosed by LN‐FNAC were included in a pooled analysis and compared to the corresponding histopathological reports. In total, 26 cases were included in this review, with a mean age of 50.5 years. Twenty‐one lymphadenopathies assessed by LN‐FNAC were diagnosed as benign, and three cases as atypical lymphoid hyperplasia; the latter were subsequently confirmed as benign (one by repetition of LN‐FNAC, two by histological control). One case of mediastinal lymphadenopathy in a patient suffering from melanoma was reported as reactive granulomatous inflammation, while one unsuspected case was diagnosed as metastasis from melanoma. In all cases, the cytological diagnoses were confirmed by follow‐up or excisional biopsy. The high diagnostic value of LN‐FNAC in excluding malignant processes was extremely useful in this context and may be particularly valuable when CNB or histological excisions are difficult to perform, as was the case during Covid lockdowns.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Covid-19 Vaccines and Lymphadenopathymentioning

confidence: 99%

Section: Pathology Of Covid-19 Post-vaccine Lymphadenopathymentioning

confidence: 99%

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COVID‐19 post‐vaccination lymphadenopathy: A review of the use of fine needle aspiration cytology

et al. 2023

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Amoxicillin/clavulanic-acid/tozinameran

2023

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2024

Infez Med

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Following the introduction of RNA-based vaccines, COVID-19 vaccine-associated clinical lymphadenopathy (C19-LAP) has been reported as a side effect. Moreover, subclinical lymphadenopathy detected on imaging (SLDI) has also been observed, mainly as incidental findings while performing screening tests on oncological patients. In these cases, surgical lymphadenectomy, fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) have been used as a valuable diagnostic tool for SLDI and C19-LAP. In this review the clinical, histologic and cytologic features of SLDI and C19-LAP have been investigated. A search for studies that reported on C19-LAP and SLDI histopathology and cytopathology was performed on PubMed and Google Scholar, on 11 January 2023. Thirty-one reports on SLDI and C19-LAP were retrieved and included in a pooled analysis. In total, we included 54 patients with a median age of 47 years. In our research, surgical excision, CNB and/ or FNAC of C19-LAP or SLDI enlarged lymph nodes have been performed in 54 cases. Of all cases, only two metastases were diagnosed and one case was diagnosed as reactive hyperplasia with atypical follicles. The remaining cases were reactive lymphadenopathy (28 cases), follicular hyperplasia (13 cases), Kikuchi-Fujimoto disease (6 cases), granulomatous lymphadenitis (2 cases), eosinophilic lymph node abscesses (1 case), Langherans cell histiocytosis (1 case), Rosai-Dorfman disease (1 case). SLDI and C19-LAP have represented a diagnostic dilemma, especially in oncologic patients. The role of different diagnostic tools for SLDI and C19-LAP has been discussed.

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Eosinophilic lymph node abscesses following a COVID-19 vaccination: A case report

Cited by 3 publications

References 12 publications

COVID‐19 post‐vaccination lymphadenopathy: A review of the use of fine needle aspiration cytology

COVID‐19 post‐vaccination lymphadenopathy: A review of the use of fine needle aspiration cytology

Amoxicillin/clavulanic-acid/tozinameran

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