Eosinophilic lung diseases.

Allen, James N.; Davis, Watson

doi:10.1164/ajrccm.150.5.7952571

Cited by 376 publications

(277 citation statements)

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“…Four of the subjects were current smokers and 1 was never a smoker. The diagnosis of AEP was established by a combination of medical history, physical examination, laboratory data, chest roentgenograms, chest computed tomography (CT), BALF findings, and Allen's criteria (18). BAL was performed in all cases upon admission.…”

Section: Study Subjectsmentioning

confidence: 99%

“…Patients present respiratory insufficiency, hypoxemia, fever, diffuse pulmonary infiltrates, increased numbers of eosinophils in BALF (of more than 25%), and no evidence of infection or previous atopic illness. It is also characterized by a rapid response to corticosteroids with resolution of symptoms and the improvement of radiographic abnormality without fibrosis (17,18). To our knowledge, no English-language reports have discussed KL-6, SP-A, or SP-D in both serum and BALF of AEP cases.…”

Section: Introductionmentioning

confidence: 99%

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KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

et al. 2005

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Section: Study Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

et al. 2005

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“…Radiographic infiltrates and blood eosinophilia may be seen in a variety of parasitic infections including Strongyloides, Ascaris, Toxocara, and Ancyclostoma in North America (26,27). However, these patients are typically not asthmatic, although they may wheeze temporarily when the lung is showered with parasites.…”

Section: Natural History Of Cssmentioning

confidence: 99%

“…Similarly, their chest radiographs usually show no lesions or fleeting airspace infiltrates. Marked eosinophilia may also be seen in tropical eosinophilia (occult filariasis caused by Wuchereria bancrofti and Brugia malayi; 26,27). Again, these patients are typically not asthmatic and most in fact have restrictive functional abnormalities.…”

Section: Natural History Of Cssmentioning

confidence: 99%

“…Organisms may be seen in the lung on biopsy with any of these infections, and occasionally, CEP-like foci are present as well (28). Eosinophilia and pulmonary infiltrates may also be seen in drug reactions, hypereosinophilic syndrome, and occasionally in fungal and tuberculous infections (27). Usually, such patients are not asthmatic.…”

Section: Natural History Of Cssmentioning

confidence: 99%

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Recent Advances in the Diagnosis of Churg-Strauss Syndrome

Churg

2001

Modern Pathology

162

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Most pathologists assume that a diagnosis of ChurgStrauss syndrome (CSS) requires the finding of necrotizing vasculitis accompanied by granulomas with eosinophilic necrosis in the setting of asthma and eosinophilia. However, recent data indicate that this definition is too narrow and that adherence to it leads to cases of CSS being missed. CSS has an early, prevasculitic phase that is characterized by tissue infiltration by eosinophils without overt vasculitis. Tissue infiltration may take the form of a simple eosinophilia in any organ, and a fine-needle aspirate showing only eosinophils may suffice for the diagnosis in this situation. The prevasculitic phase appears to respond particularly well to steroids. Even in the vasculitic phase of CSS, many cases do not show a necrotizing vasculitis but often only an apparently nondestructive infiltration of vessel walls by eosinophils. In modern biopsy materials, granulomas frequently cannot be found. In the postvasculitic phase of CSS, healed vascular lesions resemble organized thrombi but typically show very extensive destruction of elastica and, often, an absence of eosinophils. The widespread use of steroids as therapy for asthma has led to the peculiar and confusing situation in which the steroid therapy accidentally suppresses CSS and changes in steroid treatment uncover the disease; this type of "formes frustes" CSS is now well recognized with leukotriene receptor antagonist treatment and will be seen with increasing frequency as other steroid-sparing therapies for asthma are introduced.

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Acute Churg-Strauss Syndrome in an Asthmatic Patient Receiving Montelukast Therapy

Tang

Yosipovitch

2003

Arch Dermatol

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Eosinophilic lung diseases.

Cited by 376 publications

References 0 publications

KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

Recent Advances in the Diagnosis of Churg-Strauss Syndrome

Acute Churg-Strauss Syndrome in an Asthmatic Patient Receiving Montelukast Therapy

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