Eosinophilic granulomatosis with polyangiitis (EGPA) with low activity EBV replication during the COVID 19 pandemic

Mueller, Melina; Poller, Wolfgang; Klingel, Karin; Neumann, Thomas; Landmesser, Ulf; Heidecker, Bettina

doi:10.1016/j.ijcha.2022.100968

“…Despite multiple obstacles to unequivocal detection of myocardial inflammation, it has been long known that myocardial inflammation [3][4][5][6][7][8][9][10][11][12] occurs in association with multiple types of 'genetic' [13][14][15][16][17][18] and 'non-genetic' [19,20] cardiomyopathies. The possible therapeutic potential of immunomodulation has been addressed in this context [21][22][23], but this issue remains unsolved so far.…”

Section: Novel Insights Into the Role Of Inflammation In Human Cardio...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

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During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…Despite multiple obstacles to unequivocal detection of myocardial inflammation, it has been long known that myocardial inflammation [3][4][5][6][7][8][9][10][11][12] occurs in association with multiple types of 'genetic' [13][14][15][16][17] and 'non-genetic' [18,19] cardiomyopathies. Fig.…”

Section: Novel Insights Into the Role Of Inflammation In Human Cardio...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…A wide range of factors can cause myocarditis: most often viral infections, but also exposure to toxic substances or immune system activation, including hypersensitivity reactions and systemic autoimmune disorders [1] , [2] . Recently peculiar cases of myocarditis have been published in this Journal , such as a case of Kawasaki-like disease complicated by concurrent acute myocarditis [3] , eosinophilic granulomatosis with polyangiitis-related myocarditis complicated by Epstein-Barr virus reactivation likely provoked by the immunosuppressive treatment [4] , and a fatal neonatal fulminant myocarditis associated with enterovirus infection [5] .…”

Section: Myocarditismentioning

confidence: 99%

Recent highlights on myocarditis, cardiovascular complications of COVID-19, and cardiomyopathies from the International Journal of Cardiology: Heart & Vasculature

Conti¹,

Ammirati²,

Tedeschi³

et al. 2022

IJC Heart & Vasculature

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Eosinophilic granulomatosis with polyangiitis (EGPA) with low activity EBV replication during the COVID 19 pandemic

Cited by 5 publications

References 10 publications

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Recent highlights on myocarditis, cardiovascular complications of COVID-19, and cardiomyopathies from the International Journal of Cardiology: Heart & Vasculature

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