Eosinophilic granuloma of the orbit: Report of two cases

Günduz, Kaan; Palamar, Melis; Parmak, Neslihan; Kuzu, Işınsu

doi:10.1016/j.jaapos.2007.03.016

Cited by 25 publications

(21 citation statements)

References 7 publications

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“…18, 33, 45, 46 It occurs predominantly in the superior or superolateral orbital roof and exhibits other features depending on the location of the Langerhans cell infiltrate such as a visible mass with ptosis and/or (erythematous) swelling if located in the anterior orbit. This may be misinterpreted as an infectious process.…”

Section: Ocular Manifestations Of Lchmentioning

confidence: 99%

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Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature

Herwig

Wojno

Zhang

et al. 2013

Survey of Ophthalmology

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Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as unisystem (unifocal or multifocal) or multisystem disease. Orbital involvement typically manifests as a solitary lesion that carries a favorable prognosis. Herein, we describe the clinical and histologic spectrum of LCH of the orbit on the basis of five cases. One patient exhibited multifocal unisystem disease, the other four patients presented with a localized process. The typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunostaining. Transmission electron microscopy exhibited characteristic intracytoplasmic Birbeck granules. The different ophthalmic manifestations of LCH and treatment strategies are reviewed in the context of previously reported cases. As LCH may solely involve the orbit, treatment is based on the degree of organ involvement. LCH has to be included in the differential diagnosis in tumors of the ocular adnexae, in particular in young children.

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Section: Ocular Manifestations Of Lchmentioning

confidence: 99%

“…24, 48 Lesions without bone erosions have also been reported. 44, 46 As orbital lesions may be part of a multisystem disease, 21, 49 a complete medical history and systemic work-up is mandatory to rule out a multisystemic manifestation for all orbital LCH lesions. 21 A scheme for systemic evaluation is shown in Table 3.…”

Section: Ocular Manifestations Of Lchmentioning

confidence: 99%

Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature

Herwig

Wojno

Zhang

et al. 2013

Survey of Ophthalmology

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“…JXG typically shows histologic evidence of histiocytes with foamy cytoplasm and Touton- type giant cells [2]. LCH is characterized as a proliferation of Langerhans-type cells with indented grooved nucleus [3]. LCH expresses CD1a markers and has characteristic Birbeck granules on electron microscopic examination [3].…”

Section: Introductionmentioning

confidence: 99%

“…LCH is characterized as a proliferation of Langerhans-type cells with indented grooved nucleus [3]. LCH expresses CD1a markers and has characteristic Birbeck granules on electron microscopic examination [3]. Rosai-Dorfman disease involves a process of emperipolesis and cells that stain S-100 positive [1].…”

Section: Introductionmentioning

confidence: 99%

Benign Solitary Fibrous Histiocytoma of Xanthomatous Subtype of the Perilimbal Conjunctiva and Adjacent Sclera in a Youth

et al. 2018

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Aims: To report the clinical and pathological features of a benign fibrous histiocytoma of the xanthomatous subtype in the perilimbal conjunctiva and adjacent sclera in a youth. Methods: An 11-year-old Caucasian boy presented with a yellowish dome-shaped conjunctival mass abutting the inferotemporal limbus of the left eye. The tumor measured 4 mm in its maximum diameter. The lesion was excised and was noted to extend into the sclera. Three years postoperatively, there was no evidence of recurrence. Results: Histopathological examination disclosed a highly cellular lesion composed predominantly of benign-appearing foamy histiocytes without multinucleated giant cells. The tumor contained sparse fibrous septa without a storiform configuration. Immunohistochemical analysis showed diffuse cytoplasmic positive staining with adipophilin, CD34, and CD163. Conclusion: A lesion comprised of numerous homogeneous foamy histiocytes without multinucleated giant cells in the perilimbal conjunctiva and adjacent sclera of a youth is presented as a unique case of a rare variant of fibrous histiocytoma of the xanthomatous subtype.

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“…1 Several different events such as infectious, genetic, and neoplastic disorders can trigger an immune-regulatory malfunction, which results in a common phenotype but different clinical presentations of LCH. 2 Treatment options for unifocal orbital EG include surgery (biopsy or partial resection), 3 intralesional corticosteroid injection, 4 and low-dose radiation.…”

mentioning

confidence: 99%

Intralesional Injection of Interferon-α2b in Orbital Eosinophilic Granuloma

Kashkouli

Shahrzad²

2016

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Considering the immune system dysfunction in unifocal orbital eosinophilic granuloma; possible complications of surgery, intralesional steroid, and radiotherapy; immunomodulatory and cytoreductive effects of interferon-α2b; and its safety profile in treatment of ocular surface neoplasia, intralesional interferon-α2b was first commenced in treatment of 3 cases (8-, 25-, and 43-year-old men) with biopsy proven orbital eosinophilic granuloma (2007-2014). Three intralesional injections of interferon-α2b (1.5 million units/0.5 ml) were given every other day. Cases 1 and 3 showed a rapid response with no recurrence in 86 and 29 months follow up. Case 2, however, required a second course of injection 2 months after the first one due to a partial response to the first injections with no recurrence at last follow up (57 months). Transient flulike symptom was the only side effect that was observed in Cases 2 and 3.

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Eosinophilic granuloma of the orbit: Report of two cases

Cited by 25 publications

References 7 publications

Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature

Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature

Benign Solitary Fibrous Histiocytoma of Xanthomatous Subtype of the Perilimbal Conjunctiva and Adjacent Sclera in a Youth

Intralesional Injection of Interferon-α2b in Orbital Eosinophilic Granuloma

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