Eosinophilic gastroenteritis and graft‐versus‐host disease induced by transmission of Norovirus with fecal microbiota transplant

Biliński, Jarosław; Lis, Karol; Tomaszewska, Agnieszka; Pechcinska, Aleksandra; Grzesiowski, Paweł; Dzieciątkowski, Tomasz; Walesiak, Alicja; Gierej, Beata; Ziarkiewicz‐Wróblewska, Bogna; Tyszka, Martyna; Kacprzyk, Piotr; Chmielewska, Lidia; Waszczuk‐Gajda, Anna; Wiktor-Jedrzejczak, W; Basak, Grzegorz W.

doi:10.1111/tid.13386

Cited by 17 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, host reaction to Blastocystis spp. colonization may lead to eosinophilic enteritis [ 3 , 4 ]. The prevalence of this parasite has been reported more than 60% in developing countries and between 5% and 20% in developed countries [ 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran

Salehi

Mardaneh

Niazkar

et al. 2021

Journal of Parasitology Research

View full text Add to dashboard Cite

Blastocystis hominis is the most common intestinal parasite found in humans and many other hosts. Pathogenicity of Blastocystis spp. remains controversial, and it has been suggested that it may be associated with specific subtypes of the organism. This study identified the B. hominis subtypes and their prevalence rates in the northeast of Iran. A total of 1878 samples were collected from the northeast of Iran from January to December 2017. The patients’ demographic details were recorded. Samples were examined by a wet mount, and genomic DNA was extracted from positive samples. Also, PCR was done on the positive samples, and sequencing and phylogenetic analysis were subsequently performed. From 1878 collected stool samples, 152 (8.1%) Blastocystis samples were detected by the microscopic method. Of the 152 samples, Blastocystis spp. were found in 53.6% of the men and 28.9% of the women who showed clinical gastrointestinal symptoms, and a significant relationship was observed between gender and clinical symptoms ( P = 0.002 ). A meaningful relationship was found between the season and infection with this parasite ( P value = 0.003). The results of the sequencing of 22 PCR products showed the dominance of ST3, which was isolated from 10 (45.45%) patients, while ST1, ST2, and ST7 were found in 4 (18.19%), 7 (31.81%), and 1 (4.55%) patients, respectively. In this study, ST7 had a low prevalence in the northeast of Iran, and similar to previous studies, ST3 was the dominant subtype.

show abstract

Section: Introductionmentioning

confidence: 99%

Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran

Salehi

Mardaneh

Niazkar

et al. 2021

Journal of Parasitology Research

View full text Add to dashboard Cite

show abstract

“…39 Recently, severe complications (sepsis, septic shock, Norovirus infection, bacteremia with drugresistant bacteria) were reported as possibly or certainly related to FMT, also in GI-GvHD patients. 16,42,43 In our study, no immediate, procedure-related complications were observed, but we reported a fatal Adenovirus infection in a patient who had undergone FMT. Of note, we observed a total of three patients with Adenovirus viremia after FMT, two of them with low viremia, asymptomatic, and self-limiting, not needing intervention.…”

Section: Discussionmentioning

confidence: 48%

Antibiotic use and ileocolonic immune cells in patients receiving fecal microbiota transplantation for refractory intestinal GvHD: a prospective cohort study

Spindelboeck

Halwachs

Bayer

et al. 2021

Therapeutic Advances in Hematology

View full text Add to dashboard Cite

Introduction: Treatment-refractory, acute graft- versus-host disease (GvHD) of the lower gastrointestinal tract (GI) after allogeneic hematopoietic stem cell transplantation is life threatening and lacks effective treatment options. While fecal microbiota transplantation (FMT) was shown to ameliorate GI-GvHD, its mechanisms of action and the factors influencing the treatment response in humans remain unclear. The objective of this study is to assess response to FMT treatment, factors influencing response, and to study the mucosal immune cell composition in treatment-refractory GI-GvHD. Methods: Consecutive patients with treatment-refractory GI-GvHD were treated with up to six endoscopically applied FMTs. Results: We observed the response to FMT in four out of nine patients with severe, treatment refractory GI-GvHD, associated with a significant survival benefit ( p = 0.017). The concomitant use of broad-spectrum antibiotics was the main factor associated with FMT failure ( p = 0.048). In addition, antibiotic administration hindered the establishment of donor microbiota after FMT. Unlike in non-responders, the microbiota characteristics (e.g. α- and β-diversity, abundance of anaerobe butyrate-producers) in responders were more significantly similar to those of FMT donors. During active refractory GI-GvHD, an increased infiltrate of T cells, mainly Th17 and CD8+ T cells, was observed in the ileocolonic mucosa of patients, while the number of immunomodulatory cells such as regulatory T-cells and type 3 innate lymphoid cells decreased. After FMT, a change in immune cell patterns was induced, depending on the clinical response. Conclusion: This study increases the knowledge about the crucial effects of antibiotics in patients given FMT for treatment refractory GI-GvHD and defines the characteristic alterations of ileocolonic mucosal immune cells in this setting.

show abstract

“…The number of reported infection-related adverse events associated with donor FMT administration is low but transmission of pathogenic microorganisms has been described and can be fatal. 124 , 125 While there is no debate that potential donors of fecal material should undergo stringent screening, the donor screening protocols have been and, for the foreseeable future, will be subject to change as our experience with FMT therapy increases. International guidelines for donor screening protocols, for example as published by the European FMT working group, may help to reduce the variability of screening protocols used in FMT trials.…”

Section: Opportunities For Interventionmentioning

confidence: 99%

The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets

et al. 2021

View full text Add to dashboard Cite

Microbiota injury occurs in many patients undergoing allogeneic hematopoietic cell transplantation, likely as a consequence of conditioning regimens involving chemo- and radiotherapy, the widespread use of both prophylactic and therapeutic antibiotics, and profound dietary changes during the peri-transplant period. Peri-transplant dysbiosis is characterized by a decrease in bacterial diversity, loss of commensal bacteria and single-taxon domination (e.g., with Enterococcal strains). Clinically, deviation of the post-transplant microbiota from a normal, high-diversity, healthy state has been associated with increased risk of bacteremia, development of graft-versus-host disease and decreases in overall survival. A number of recent clinical trials have attempted to target the microbiota in allogeneic hematopoietic cell transplantation patients via dietary interventions, selection of therapeutic antibiotics, administration of pre- or pro-biotics, or by performing fecal microbiota transplantation. These strategies have yielded promising results but the mechanisms by which these interventions influence transplant-related complications remain largely unknown. In this review we summarize the current approaches to targeting the microbiota, discuss potential underlying mechanisms and highlight the key outstanding areas that require further investigation in order to advance microbiota- targeting therapies.

show abstract

Eosinophilic gastroenteritis and graft‐versus‐host disease induced by transmission of Norovirus with fecal microbiota transplant

Cited by 17 publications

References 12 publications

Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran

Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran

Antibiotic use and ileocolonic immune cells in patients receiving fecal microbiota transplantation for refractory intestinal GvHD: a prospective cohort study

The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets

Contact Info

Product

Resources

About