Eosinophilic Fasciitis: Clinical Signs Leading to Diagnosis

Coimbra, Túlio Marcos; Santos, Jeane Barco dos; Shinkado, Yumi Ricucci; Delicato, Guilherme; Arimura, Amanda Miki; Paiva, Edison Ferreira de; Lichtenstein, A.

doi:10.7326/aimcc.2022.0237

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Also, in AS cases, both baseline and post-baseline serum CRP titers may predict response to treatment, but even if various data conclude that CRP SNPs are associated with AS, some of them are independent of disease severity [ 721 , 722 , 723 , 724 , 725 ]. Some case reports reveal that CRP can be notably elevated during the diagnosis of eosinophilic fasciitis [ 726 , 727 ]. Apart from myasthenia Gravis, on which data on CRP are limited, and polymyositis, in which CRP can be elevated but still with no clinical utility in being a single biomarker, CRP can be an indicator of disease activity, and persistent elevated values may predict amyloidosis in juvenile chronic arthritis.…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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“…EF has been predominantly reported in middle-age white adults with limited pediatric cases (7,(11)(12)(13)(14)(15). To expand upon and improve the understanding of the distinctive presentation of EF in the pediatric population, we report the epidemiology, clinical characteristics, treatment, and course for six juvenile EF patients.…”

Section: Introductionmentioning

confidence: 99%

Juvenile Eosinophilic Fasciitis: A Single Center Case Series

Stubbs,

Ogunbona,

Beil

et al. 2023

Preprint

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Background:Eosinophilic fasciitis (EF) is a rare disease characterized by skin induration and musculoskeletal abnormalities. Diagnostic criteria for EF are based on adult populations. There is a need to expand the literature on EF in children due to limited reported cases and potential differences compared to adults.Methods:We conducted a retrospective review of medical records for six pediatric patients diagnosed with EF at our institution between November 2011 and April 2023. Inclusion criteria required patients to be under 18 years of age at the time of diagnosis and to have confirmed diagnosis through clinical history, imaging, and histology.Results:Most of our cohort were female (83%) and non-Hispanic white (50%). Age at diagnosis ranged from 4 to 16 years. Duration of symptoms before diagnosis varied from 1 to 12 months. Follow-up periods ranged from 14 to 123 months. Concurrent medical conditions included localized scleroderma, acquired thrombophilia, and juvenile idiopathic arthritis. Patients presented with progressive painful swelling, severe joint limitations, and positive prayer sign. Initial regimens involved corticosteroids and methotrexate. Hydroxychloroquine, immunoglobulin, mycophenolate mofetil, rituximab, and tocilizumab were also used depending on the patient’s disease severity and course.Conclusions:Juvenile EF may manifest as swelling and progressive induration without apparent skin abnormalities. Unlike adult populations, no underlying malignancies or associations with trauma were observed in our cohort. Our cases did not exhibit systemic involvement observed in previous studies on juvenile EF. While non-specific, the prayer sign may aid in early recognition of juvenile EF and help prevent long-term disability.

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Eosinophilic Fasciitis: Clinical Signs Leading to Diagnosis

Cited by 2 publications

References 14 publications

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Juvenile Eosinophilic Fasciitis: A Single Center Case Series

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