Eosinophilic Esophagitis

Furuta, Glenn T.

doi:10.1159/000268132

Cited by 7 publications

(14 citation statements)

References 162 publications

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“…In the esophagus, these approaches are required to establish the existence and identity of stem cells and to characterize their self-renewal and multipotency properties. This is critical for our understanding of the cellular basis of widely prevalent esophageal diseases, such as acid reflux-induced esophagitis, eosinophilic esophagitis, and esophageal carcinoma (18,19).…”

Section: Krt15-crepr1 R26mentioning

confidence: 99%

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

Giroux¹,

Lento²,

Islam

et al. 2017

Journal of Clinical Investigation

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Section: Krt15-crepr1 R26mentioning

confidence: 99%

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

Giroux¹,

Lento²,

Islam

et al. 2017

Journal of Clinical Investigation

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“…As a consequence of intense research in the field of esophageal eosinophilia, our understanding of eosinophilic esophagitis (EoE) has developed from strict clinic-pathologic criteria leading toward a conceptual definition which includes pathogenic aspects (1)(2)(3). According to current recommendations, EoE represents a chronic, immune/antigen-mediated esophageal disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation (2).…”

Section: Current Definition Of Eoementioning

confidence: 99%

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Simon

Cianferoni

Spergel

et al. 2016

Allergy

199

130

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Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets. Recent research has, however, indicated that the pathogenesis of EoE is distinct from IgE-mediated food allergy. In this review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the pathogenesis of EoE. Although food has been recognized as a trigger factor of EoE, the mechanism by which it initiates or facilitates eosinophilic inflammation appears to be largely independent of IgE and needs to be further investigated. Understanding the pathogenic role of food in EoE is a prerequisite for the development of specific diagnostic tools and targeted therapeutic procedures.Abbreviations ACD, allergic contact dermatitis; AD, atopic dermatitis; APT, atopy patch test; DHR, drug hypersensitivity reactions; EoE, eosinophilic esophagitis; FPIES, food protein-induced enterocolitis; GERD, gastroesophageal reflux disease; GI, gastrointestinal; IBD, inflammatory bowel disease; Ig, immunoglobulin; OAS, oral allergy syndrome; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia; SFED, six-food elimination diet; SPT, skin prick test; TCR, T-cell receptor; TNF, tumor necrosis factor.Allergy 71 (2016) 611-620

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“…Children generally present with non-specific symptoms of GERD, abdominal pain or failure to thrive; other present with dysphagia and esophageal food impaction [4] . The entire esophagus is often infiltrated with increased number of eosinophils [> 15 to 20 eosinophils per high power field (HPF)] a differential feature from the increased number of eosinophils found occasionally in the distal esophagus in patients with GERD of less than 15 eosinophils per HPF [16,17] . A recent study demonstrated that a cutoff value of at least 15 eosinophils per high-power field has a sensitivity of 100% and specificity of 96% for establishing the histologic diagnosis of eosinophilic esophagitis, irrespective of location of the sample (proximal or distal esophagus).…”

Section: Clinical Presentationmentioning

confidence: 99%

Eosinophilic esophagitis: New insights in pathogenesis and therapy

Guarino

Cicala

Behar

2016

WJGPT

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Eosinophilic esophagitis (EoE) is a clinico-pathological entity with esophageal symptoms and dense esophageal eosinophilic infiltration throughout the esophagus that may persist despite treatment with proton pump inhibitors. This eosinophilic infiltration is usually absent in the stomach, small intestine and colon, although there are a number of reports of patients with a multiorgan involvement. EoE is associated with abnormalities involving TH2-dependent immunity, with multiple environmental factors strongly contributing to disease expression. The layer of the esophagus affected by the eosinophilic infiltration causes the specific symptoms. Esophageal involvement results mostly in dysphagia for solids that can be severe enough to cause recurrent esophageal obstruction with typical endoscopic features suggesting esophageal remodeling and pathological changes of eosinophilic infiltration of the mucosa, sub-epithelial fibrosis and muscle hypertrophy. This disease is frequently associated with other allergic conditions such as allergic asthma, allergic dermatitis and eosinophilia. The treatment of patients with EoE depends on the severity of the symptoms and of the inflammatory process as well as to their response to a gradual step-up treatment. The first line of treatment consists of steroid containing local inhalers. If unresponsive they are then treated with oral steroids. Intravenous interleukin blockers seem to have a consistent positive therapeutic effect. Core tip: Eosinophilic esophagitis is a clinico-pathological entity characterized by esophageal symptoms and dense esophageal eosinophilic infiltration throughout the esophagus. Our manuscript provides a deep description of the disease showing that many efforts have been made in the last decades in understanding REVIEWSubmit a

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Eosinophilic Esophagitis

Cited by 7 publications

References 162 publications

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Eosinophilic esophagitis: New insights in pathogenesis and therapy

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