Eosinophilic esophagitis in children under the age of 5 years: Clinical characteristics

Sun, Ravi W.; Bonilla‐Velez, Juliana; Pesek, Robert D.; Johnson, Adam B.; Cleves, Mario A.; Richter, Gresham T.

doi:10.1002/lary.26838

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…First of all, as observed in literature, symptoms in our cohort differed according to the age: child under five years presented with reflux symptoms, vomiting, dysphagia, feeding difficulty and failure to thrive, whereas older children and adolescents more likely presented with food impaction, abdominal pain and dysphagia. (7,8) These two patterns of symptoms could be linked to the natural course, with a first inflammatory phase followed by fibrosis. (9) Cough is rarely reported in the literature but appeared as a frequent symptom in our cohort, especially between three and 10 years and should be considered as a suggestive symptom of EoE in young children.…”

Section: Discussionmentioning

confidence: 99%

Children with eosinophilic esophagitis in real life: 10 years’ experience with a focus on allergic management

Azzano

Truc

Collardeau‐Frachon

et al. 2020

Allergologia et Immunopathologia

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Section: Discussionmentioning

confidence: 99%

Children with eosinophilic esophagitis in real life: 10 years’ experience with a focus on allergic management

Azzano

Truc

Collardeau‐Frachon

et al. 2020

Allergologia et Immunopathologia

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“…In children, age significantly influences GP symptom expression (Table 1) 13,14 ; a finding that is seen in other pediatric disorders. 16,17 Vomiting is most common in infants and young children, whereas abdominal pain predominates in older children and adolescents (Table 1). 13,14 These data highlight that symptom assessment in children should be tailored to the age of the child.…”

Section: Symptoms and Symptom Assessmentmentioning

confidence: 99%

Childhood gastroparesis is a unique entity in need of further investigation

Febo‐Rodriguez

Chumpitazi

Shulman

2019

Neurogastroenterology Motil

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Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures. Purpose The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.

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“…44 Younger patients tend to present with more nonspecific symptoms, including feeding difficulties, dysphagia to liquids and/or solids, vomiting, regurgitation, and poor weight gain, while older adolescents and adults present with dysphagia to solids and food impactions. 45,46 Although EoE is generally considered a condition of the gastrointestinal tract, EoE can also present with extraesophageal manifestations, including airway and respiratory symptoms such as CC, as well as RC, hoarseness, and dysphonia. 47 There is a strong association between EoE and other atopic conditions, such as food allergies, environmental allergies, asthma, and atopic dermatitis.…”

Section: Important Non-ent Causes Of CC With Feeding/weight Issues: Eoementioning

confidence: 99%

A multi‐disciplinary approach to chronic cough in children

Mukerji

Yenduri

Chiou

et al. 2022

Laryngoscope Investig Oto

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Objectives (1) To highlight the important causes of chronic and recurrent cough in children. (2) To discuss multidisciplinary approach to management of chronic/recurrent pediatric cough. Methods Review of scholarly articles, guidelines, expert panels via PubMed and Google Scholar. Conclusion Chronic cough (CC) in children is mainly attributed to persistent bacterial bronchitis, asthma, nonspecific cough, and gastroesophageal reflux disease (GERD) symptoms. A multi‐disciplinary approach is cost‐effective and aids with earlier diagnosis and appropriate treatment. Congenital or acquired narrowing of the subglottis is the leading ENT cause for recurrent croup (RC) in children. Laryngeal cleft‐type 1 is commonly seen in children with recurrent aspiration and CC. Children are usually referred to pulmonologists for wet cough not responding to treatment. Eosinophilic esophagitis (EoE) and GERD should be considered in the differential diagnosis of CC in children with both respiratory symptoms and failure to thrive. Level of Evidence: 2a

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Eosinophilic esophagitis in children under the age of 5 years: Clinical characteristics

Abstract: 4. Laryngoscope, 128:798-805, 2018.

Cited by 13 publications

References 19 publications

Children with eosinophilic esophagitis in real life: 10 years’ experience with a focus on allergic management

Children with eosinophilic esophagitis in real life: 10 years’ experience with a focus on allergic management

Childhood gastroparesis is a unique entity in need of further investigation

A multi‐disciplinary approach to chronic cough in children

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